HUMAN:RET4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RBP4
Protein Name(s)	Retinol-binding protein 4 Plasma retinol-binding protein PRBP RBP Plasma retinol-binding protein(1-182) Plasma retinol-binding protein(1-181) Plasma retinol-binding protein(1-179) Plasma retinol-binding protein(1-176)
External Links
UniProt	P02753
EMBL	X00129 AL356214 CH471066 CH471066 CH471066 BC020633 X02775 X02824 AF119868 AF025334 AF025335
CCDS	CCDS31249.1
PIR	A93494
RefSeq	NP_006735.2
UniGene	Hs.50223
PDB	1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ
PDBsum	1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ
ProteinModelPortal	P02753
SMR	P02753
BioGrid	111884
IntAct	P02753
STRING	9606.ENSP00000360519
BindingDB	P02753
ChEMBL	CHEMBL3100
DrugBank	DB00162
PhosphoSite	P02753
DMDM	62298174
SWISS-2DPAGE	P02753
MaxQB	P02753
PaxDb	P02753
PRIDE	P02753
Ensembl	ENST00000371464 ENST00000371467 ENST00000615669
GeneID	5950
KEGG	hsa:5950
UCSC	uc001kit.3
CTD	5950
GeneCards	GC10M095341
H-InvDB	HIX0009047
HGNC	HGNC:9922
HPA	CAB004555 HPA001641
MIM	180250 615147
neXtProt	NX_P02753
Orphanet	352718
PharmGKB	PA34289
eggNOG	NOG40507
GeneTree	ENSGT00510000047107
HOVERGEN	HBG004493
InParanoid	P02753
KO	K18271
OMA	TWYAVAK
OrthoDB	EOG747PK3
PhylomeDB	P02753
TreeFam	TF331445
BioCyc	MetaCyc:ENSG00000138207-MONOMER
Reactome	REACT_160130 REACT_160156 REACT_24968
ChiTaRS	RBP4
EvolutionaryTrace	P02753
GeneWiki	Retinol_binding_protein_4
GenomeRNAi	5950
NextBio	23182
PRO	PR:P02753
Proteomes	UP000005640
Bgee	P02753
CleanEx	HS_RBP4
ExpressionAtlas	P02753
Genevestigator	P02753
GO	GO:0005829 GO:0005576 GO:0005615 GO:0070062 GO:0043234 GO:0016918 GO:0019841 GO:0034632 GO:0048738 GO:0050908 GO:0048562 GO:0060059 GO:0048706 GO:0001654 GO:0048807 GO:0006094 GO:0042593 GO:0007507 GO:0060347 GO:0030324 GO:0030277 GO:0008584 GO:0060044 GO:0007603 GO:0051024 GO:0032024 GO:0045471 GO:0032868 GO:0032526 GO:0042574 GO:0001523 GO:0042572 GO:0034633 GO:0007283 GO:0060157 GO:0060065 GO:0060068
Gene3D	2.40.128.20
InterPro	IPR012674 IPR011038 IPR002345 IPR022271 IPR022272 IPR000566 IPR002449
PANTHER	PTHR11873
Pfam	PF00061
PIRSF	PIRSF036893 PIRSF500204
PRINTS	PR00179 PR01174
SUPFAM	SSF50814
PROSITE	PS00213

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005501	retinoid binding	PMID:24700313^[1]	ECO:0000316			F		epicardial adipocytes expressed significantly lower levels of RBP4	Missing: with/from CACAO 10043
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12237133^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060347	heart trabecula formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0060157	urinary bladder development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0060068	vagina development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0051024	positive regulation of immunoglobulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0048807	female genitalia morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0048562	embryonic organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:17003346^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	PMID:10232633^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034633	retinol transport	PMID:571335^[7]	ECO:0000305	curator inference used in manual assertion	GO:0019841	P		Seeded From UniProt	complete
enables	GO:0034632	retinol transmembrane transporter activity	PMID:571335^[7]	ECO:0000305	curator inference used in manual assertion	GO:0019841	F		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:571335^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:16034410^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0030277	maintenance of gastrointestinal epithelium	PMID:10944490^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019841	retinol binding	PMID:571335^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	PMID:18466349^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17003346^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:5132677^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	C		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:10232633^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00724	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	F		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	P		Seeded From UniProt	complete
involved_in	GO:0034633	retinol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	C		Seeded From UniProt	complete
enables	GO:0019841	retinol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04916 ensembl:ENSRNOP00000021055	C		Seeded From UniProt	complete
enables	GO:0005501	retinoid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002449	F		Seeded From UniProt	complete
enables	GO:0034632	retinol transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002449	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2466828	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2453876 Reactome:R-HSA-2453863 Reactome:R-HSA-2453818 Reactome:R-HSA-2404135 Reactome:R-HSA-2404134	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634 Reactome:R-HSA-2453902	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P		Seeded From UniProt	complete
enables	GO:0016918	retinal binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0845	F		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
enables	GO:0019841	retinol binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0683	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Agra, RM et al. (2014) Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease. Inflammation 37 1504-12 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Kiernan, UA et al. (2002) Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay. Biochem. Biophys. Res. Commun. 297 401-5 PubMed GONUTS page
↑ ^5.0 ^5.1 Janke, J et al. (2006) Retinol-binding protein 4 in human obesity. Diabetes 55 2805-10 PubMed GONUTS page
↑ ^6.0 ^6.1 Biesalski, HK et al. (1999) Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am. J. Clin. Nutr. 69 931-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Fex, G & Hansson, B (1979) Retinol-binding protein from human urine and its interaction with retinol and prealbumin. Eur. J. Biochem. 94 307-13 PubMed GONUTS page
↑ Yang, Q et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-62 PubMed GONUTS page
↑ Quadro, L et al. (2000) Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. J. Infect. Dis. 182 Suppl 1 S97-S102 PubMed GONUTS page
↑ Bahr, MJ et al. (2009) Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis. Clin. Endocrinol. (Oxf) 70 60-5 PubMed GONUTS page
↑ Rask, L et al. (1971) Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content. J. Biol. Chem. 246 6638-46 PubMed GONUTS page

[PMID:24700313-1] Agra, RM et al. (2014) Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease. Inflammation 37 1504-12 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:12237133-4] Kiernan, UA et al. (2002) Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay. Biochem. Biophys. Res. Commun. 297 401-5 PubMed GONUTS page

[PMID:17003346-5] 5.0 ^5.1 Janke, J et al. (2006) Retinol-binding protein 4 in human obesity. Diabetes 55 2805-10 PubMed GONUTS page

[PMID:10232633-6] 6.0 ^6.1 Biesalski, HK et al. (1999) Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am. J. Clin. Nutr. 69 931-6 PubMed GONUTS page

[PMID:571335-7] 7.0 ^7.1 ^7.2 ^7.3 Fex, G & Hansson, B (1979) Retinol-binding protein from human urine and its interaction with retinol and prealbumin. Eur. J. Biochem. 94 307-13 PubMed GONUTS page

[PMID:16034410-8] Yang, Q et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-62 PubMed GONUTS page

[PMID:10944490-9] Quadro, L et al. (2000) Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. J. Infect. Dis. 182 Suppl 1 S97-S102 PubMed GONUTS page

[PMID:18466349-10] Bahr, MJ et al. (2009) Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis. Clin. Endocrinol. (Oxf) 70 60-5 PubMed GONUTS page

[PMID:5132677-11] Rask, L et al. (1971) Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content. J. Biol. Chem. 246 6638-46 PubMed GONUTS page

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HUMAN:RET4

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Notes

References

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