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HUMAN:REN3B

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UPF3B (synonyms: RENT3B, UPF3X)
Protein Name(s) Regulator of nonsense transcripts 3B

Nonsense mRNA reducing factor 3B Up-frameshift suppressor 3 homolog B hUpf3B Up-frameshift suppressor 3 homolog on chromosome X hUpf3p-X

External Links
UniProt Q9BZI7
EMBL AY013251
AF318576
CH471161
CH471161
CH471161
CH471161
BC121017
CCDS CCDS14587.1
CCDS14588.1
RefSeq NP_075386.1
NP_542199.1
UniGene Hs.103832
PDB 1UW4
2XB2
PDBsum 1UW4
2XB2
ProteinModelPortal Q9BZI7
SMR Q9BZI7
BioGrid 122396
CORUM Q9BZI7
DIP DIP-31143N
IntAct Q9BZI7
MINT Q9BZI7
STRING 9606.ENSP00000276201
iPTMnet Q9BZI7
PhosphoSitePlus Q9BZI7
BioMuta UPF3B
DMDM 60390643
EPD Q9BZI7
MaxQB Q9BZI7
PaxDb Q9BZI7
PeptideAtlas Q9BZI7
PRIDE Q9BZI7
Ensembl ENST00000276201
ENST00000345865
GeneID 65109
KEGG hsa:65109
UCSC uc004erz.3
CTD 65109
DisGeNET 65109
EuPathDB HostDB:ENSG00000125351.10
GeneCards UPF3B
HGNC HGNC:20439
HPA HPA001592
HPA001800
HPA001882
MalaCards UPF3B
MIM 300298
300676
neXtProt NX_Q9BZI7
OpenTargets ENSG00000125351
Orphanet 323
776
777
PharmGKB PA128394708
eggNOG KOG1295
ENOG41122XD
GeneTree ENSGT00390000017146
HOGENOM HOG000230909
HOVERGEN HBG059714
InParanoid Q9BZI7
KO K14328
OMA QDPEFMA
OrthoDB EOG091G0JKF
PhylomeDB Q9BZI7
TreeFam TF316034
Reactome R-HSA-109688
R-HSA-159236
R-HSA-72163
R-HSA-72187
R-HSA-9010553
R-HSA-975957
SIGNOR Q9BZI7
ChiTaRS UPF3B
EvolutionaryTrace Q9BZI7
GeneWiki UPF3B
GenomeRNAi 65109
PRO PR:Q9BZI7
Proteomes UP000005640
Bgee ENSG00000125351
CleanEx HS_UPF3B
ExpressionAtlas Q9BZI7
Genevisible Q9BZI7
GO GO:0005737
GO:0005829
GO:0035145
GO:0005815
GO:0005730
GO:0005654
GO:0005634
GO:0003729
GO:0003723
GO:0017056
GO:0031124
GO:0006406
GO:0000398
GO:0000184
GO:0045727
GO:0006405
GO:0006369
CDD cd12728
Gene3D 3.30.70.330
InterPro IPR012677
IPR035979
IPR005120
IPR034979
Pfam PF03467
SUPFAM SSF54928

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045727

positive regulation of translation

PMID:16601204[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

colocalizes_with

GO:0035145

exon-exon junction complex

PMID:12718880[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0035145

exon-exon junction complex

PMID:11546873[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035145

exon-exon junction complex

PMID:16601204[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11163187[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11163187[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0017056

structural constituent of nuclear pore

PMID:11163187[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:11546873[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

PMID:18369367[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

PMID:16601204[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

PMID:11163187[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045727

positive regulation of translation

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000318879
UniProtKB:Q9BZI7
UniProtKB:Q9H1J1

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000318879
SGD:S000003304
WB:WBGene00004882

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000318879
SGD:S000003304
TAIR:locus:2009026
UniProtKB:Q9BZI7

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000318879
TAIR:locus:2009026
UniProtKB:Q9BZI7

F

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034923
PANTHER:PTN000318879
TAIR:locus:2009026
UniProtKB:Q9BZI7
UniProtKB:Q9H1J1
WB:WBGene00004882

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039722

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR035979

F

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

Reactome:R-HSA-72187

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

Reactome:R-HSA-75098
Reactome:R-HSA-75096

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006405

RNA export from nucleus

Reactome:R-HSA-159101

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-927889
Reactome:R-HSA-927836
Reactome:R-HSA-927832
Reactome:R-HSA-927813
Reactome:R-HSA-75098
Reactome:R-HSA-75097

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8849157
Reactome:R-HSA-75097
Reactome:R-HSA-75096
Reactome:R-HSA-72185
Reactome:R-HSA-72180
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-159101
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reactome:R-HSA-927802

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051028

mRNA transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0509

P

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0866

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Kunz, JB et al. (2006) Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA 12 1015-22 PubMed GONUTS page
  2. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  3. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. ↑ Gehring, NH et al. (2003) Y14 and hUpf3b form an NMD-activating complex. Mol. Cell 11 939-49 PubMed GONUTS page
  5. ↑ 5.0 5.1 Kim, VN et al. (2001) Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science 293 1832-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Lykke-Andersen, J et al. (2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103 1121-31 PubMed GONUTS page
  7. ↑ Woeller, CF et al. (2008) NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep. 9 446-51 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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