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HUMAN:REG3A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | REG3A (synonyms: HIP, PAP, PAP1) | |
| Protein Name(s) | Regenerating islet-derived protein 3-alpha
REG-3-alpha Hepatointestinal pancreatic protein HIP/PAP Human proislet peptide Pancreatitis-associated protein 1 Regenerating islet-derived protein III-alpha Reg III-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form | |
| External Links | ||
| UniProt | Q06141 | |
| EMBL | D13510 M84337 S51768 X68641 L15533 BC036776 | |
| CCDS | CCDS1965.1 | |
| PIR | A49616 | |
| RefSeq | NP_002571.1 NP_620354.1 NP_620355.1 | |
| UniGene | Hs.567312 | |
| PDB | 1UV0 2GO0 4MTH | |
| PDBsum | 1UV0 2GO0 4MTH | |
| ProteinModelPortal | Q06141 | |
| SMR | Q06141 | |
| BioGrid | 111103 | |
| DIP | DIP-60688N | |
| IntAct | Q06141 | |
| STRING | 9606.ENSP00000304311 | |
| MEROPS | I63.002 | |
| TCDB | 1.C.111.1.2 | |
| UniLectin | Q06141 | |
| BioMuta | REG3A | |
| DMDM | 464341 | |
| EPD | Q06141 | |
| jPOST | Q06141 | |
| PaxDb | Q06141 | |
| PeptideAtlas | Q06141 | |
| PRIDE | Q06141 | |
| ProteomicsDB | 58418 | |
| Ensembl | ENST00000305165 ENST00000393878 ENST00000409839 | |
| GeneID | 5068 | |
| KEGG | hsa:5068 | |
| CTD | 5068 | |
| DisGeNET | 5068 | |
| EuPathDB | HostDB:ENSG00000172016.15 | |
| GeneCards | REG3A | |
| HGNC | HGNC:8601 | |
| HPA | HPA047894 HPA048334 HPA060705 | |
| MIM | 167805 | |
| neXtProt | NX_Q06141 | |
| OpenTargets | ENSG00000172016 | |
| PharmGKB | PA32931 | |
| eggNOG | KOG4297 ENOG410XPJ1 | |
| GeneTree | ENSGT00940000162300 | |
| HOGENOM | HOG000010281 | |
| HOVERGEN | HBG004151 | |
| InParanoid | Q06141 | |
| OMA | NCDVKLP | |
| OrthoDB | 1509611at2759 | |
| PhylomeDB | Q06141 | |
| Reactome | R-HSA-6803157 | |
| ChiTaRS | REG3A | |
| EvolutionaryTrace | Q06141 | |
| GeneWiki | REG3A | |
| GenomeRNAi | 5068 | |
| PMAP-CutDB | Q06141 | |
| PRO | PR:Q06141 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000172016 | |
| Genevisible | Q06141 | |
| GO | GO:0005737 GO:0005576 GO:0005615 GO:0030246 GO:0042802 GO:0070492 GO:0042834 GO:0004888 GO:0006953 GO:0061844 GO:0019730 GO:0008283 GO:0044278 GO:0007157 GO:0007275 GO:0045617 GO:0008284 GO:0010838 GO:0090303 GO:0043434 | |
| Gene3D | 3.10.100.10 | |
| InterPro | IPR001304 IPR016186 IPR018378 IPR016187 | |
| Pfam | PF00059 | |
| SMART | SM00034 | |
| SUPFAM | SSF56436 | |
| PROSITE | PS00615 PS50041 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044278 |
cell wall disruption in other organism |
ECO:0001249 |
P |
Fig. 1 shows that when active Human Reg3a (as opposed to the inactive pro-Reg3a) is introduced to Listeria monoctogenes cells, their membranes become more permeable. |
complete | |||||
| GO:0046930 |
pore complex |
ECO:0007044 |
C |
Fig. 2 shows a transmission EM of the pore formed by human Reg3a in a lipid bilayer. |
complete | |||||
|
involved_in |
GO:0090303 |
positive regulation of wound healing |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045617 |
negative regulation of keratinocyte differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010838 |
positive regulation of keratinocyte proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070492 |
oligosaccharide binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109406 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109406 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044278 |
cell wall disruption in other organism |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109406 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043434 |
response to peptide hormone |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000514573 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042834 |
peptidoglycan binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109406 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000514573 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000514573 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97142 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007157 |
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019730 |
antimicrobial humoral response |
Reactome:R-HSA-6803157 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6801808 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mukherjee, S et al. (2014) Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505 103-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Lasserre, C et al. (1992) A novel gene (HIP) activated in human primary liver cancer. Cancer Res. 52 5089-95 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Christa, L et al. (1996) HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. Am. J. Physiol. 271 G993-1002 PubMed GONUTS page
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