HUMAN:RASK

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KRAS (synonyms: KRAS2, RASK2)
Protein Name(s)	GTPase KRas K-Ras 2 Ki-Ras c-K-ras c-Ki-ras GTPase KRas, N-terminally processed
External Links
UniProt	P01116
EMBL	L00049 L00045 L00046 L00047 L00048 L00045 L00046 L00047 M54968 AF493917 BT007153 AK292510 CH471094 CH471094 EU332849 BC013572 K01519 K01520 M25876 M34904 M30539 X01669 X02825 K03210 K03209
CCDS	CCDS8702.1 CCDS8703.1
PIR	A93311 B93311
RefSeq	NP_004976.2 NP_203524.1 XP_006719132.1
UniGene	Hs.37003 Hs.505033
PDB	1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03
PDBsum	1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03
ProteinModelPortal	P01116
SMR	P01116
BioGrid	110043
DIP	DIP-33951N
IntAct	P01116
MINT	MINT-131580
STRING	9606.ENSP00000256078
BindingDB	P01116
ChEMBL	CHEMBL2189121
PhosphoSite	P01116
DMDM	131875
MaxQB	P01116
PaxDb	P01116
PeptideAtlas	P01116
PRIDE	P01116
DNASU	3845
Ensembl	ENST00000256078 ENST00000311936
GeneID	3845
KEGG	hsa:3845
UCSC	uc001rgp.1 uc001rgq.1
CTD	3845
GeneCards	GC12M025358
GeneReviews	KRAS
HGNC	HGNC:6407
MIM	190070 601626 607785 609942 613659 615278
neXtProt	NX_P01116
Orphanet	1340 1333 144 86834 2612 648 251612 268114 357194 357191
PharmGKB	PA30196
eggNOG	COG1100
GeneTree	ENSGT00770000120468
HOGENOM	HOG000233973
HOVERGEN	HBG009351
InParanoid	P01116
KO	K07827
OMA	VDMNQAR
OrthoDB	EOG7QVM41
PhylomeDB	P01116
TreeFam	TF312796
Reactome	REACT_111040 REACT_115852 REACT_115854 REACT_115993 REACT_116005 REACT_118778 REACT_12033 REACT_12065 REACT_121096 REACT_121398 REACT_12579 REACT_12606 REACT_12621 REACT_147814 REACT_163701 REACT_17025 REACT_18334 REACT_2077 REACT_21247 REACT_21374 REACT_228024 REACT_524 REACT_614 REACT_661 REACT_962
SignaLink	P01116
ChiTaRS	KRAS
EvolutionaryTrace	P01116
GeneWiki	KRAS
GenomeRNAi	3845
NextBio	15131
PRO	PR:P01116
Proteomes	UP000005640
Bgee	P01116
CleanEx	HS_KRAS
ExpressionAtlas	P01116
Genevestigator	P01116
GO	GO:0005737 GO:0031234 GO:0005925 GO:0016020 GO:0045121 GO:0005739 GO:0005886 GO:0019003 GO:0019002 GO:0005525 GO:0032403 GO:0030036 GO:0000186 GO:0007411 GO:0007596 GO:0019221 GO:0007173 GO:0060441 GO:0038095 GO:0008543 GO:0006184 GO:0045087 GO:0008286 GO:0050900 GO:0000165 GO:0045596 GO:0043524 GO:0048011 GO:0008284 GO:0010628 GO:0043406 GO:0051092 GO:0051000 GO:0001934 GO:0035022 GO:0007265 GO:0048169 GO:0032228 GO:0051384 GO:0051385 GO:0007264 GO:0035176 GO:0051146 GO:0008542
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR020849
PANTHER	PTHR24070
Pfam	PF00071
PRINTS	PR00449
SMART	SM00173
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0031647	regulation of protein stability	PMID:24623306^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23698361^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:23698361^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:23698361^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22065586^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:22065586^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:23209302^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000774	positive regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	C		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0035900	response to isolation stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
enables	GO:0030275	LRR domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	F		Seeded From UniProt	complete
enables	GO:0019002	GMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	F		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	C		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08644 ensembl:ENSRNOP00000012588	P		Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0038002	endocrine signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0035022	positive regulation of Rac protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0021897	forebrain astrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32883 ensembl:ENSMUSP00000032399	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR005225 InterPro:IPR020849	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26051715^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01116-2	F		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	Reactome:R-HSA-167044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8981355 Reactome:R-HSA-8981353 Reactome:R-HSA-8941628 Reactome:R-HSA-8941623 Reactome:R-HSA-8941618 Reactome:R-HSA-8941613 Reactome:R-HSA-8936731 Reactome:R-HSA-8936676 Reactome:R-HSA-8853307 Reactome:R-HSA-8851899 Reactome:R-HSA-8851877 Reactome:R-HSA-8851827 Reactome:R-HSA-6803240 Reactome:R-HSA-6803234 Reactome:R-HSA-6803233 Reactome:R-HSA-6803230 Reactome:R-HSA-6802943 Reactome:R-HSA-6802942 Reactome:R-HSA-6802941 Reactome:R-HSA-6802937 Reactome:R-HSA-6802926 Reactome:R-HSA-6802925 Reactome:R-HSA-6802924 Reactome:R-HSA-6802922 Reactome:R-HSA-6802921 Reactome:R-HSA-6802919 Reactome:R-HSA-6802918 Reactome:R-HSA-6802916 Reactome:R-HSA-6802915 Reactome:R-HSA-6802914 Reactome:R-HSA-6802908 Reactome:R-HSA-6802837 Reactome:R-HSA-6802834 Reactome:R-HSA-5675433 Reactome:R-HSA-5675431 Reactome:R-HSA-5675417 Reactome:R-HSA-5674022 Reactome:R-HSA-5674018 Reactome:R-HSA-5672980 Reactome:R-HSA-5672978 Reactome:R-HSA-5672973 Reactome:R-HSA-5672972 Reactome:R-HSA-5672969 Reactome:R-HSA-5672966 Reactome:R-HSA-5672965 Reactome:R-HSA-5672950 Reactome:R-HSA-5658435 Reactome:R-HSA-5658231 Reactome:R-HSA-5655347 Reactome:R-HSA-5655326 Reactome:R-HSA-5655277 Reactome:R-HSA-5655241 Reactome:R-HSA-5654663 Reactome:R-HSA-5654647 Reactome:R-HSA-5654618 Reactome:R-HSA-5654600 Reactome:R-HSA-5654426 Reactome:R-HSA-5654413 Reactome:R-HSA-5654402 Reactome:R-HSA-5654392 Reactome:R-HSA-5637808 Reactome:R-HSA-5637806 Reactome:R-HSA-5624494 Reactome:R-HSA-5624492 Reactome:R-HSA-5624486 Reactome:R-HSA-5621573 Reactome:R-HSA-5218845 Reactome:R-HSA-392054 Reactome:R-HSA-2424477 Reactome:R-HSA-2179407 Reactome:R-HSA-210977 Reactome:R-HSA-186834 Reactome:R-HSA-177945 Reactome:R-HSA-177938 Reactome:R-HSA-170986 Reactome:R-HSA-1433471 Reactome:R-HSA-1306972 Reactome:R-HSA-1250383 Reactome:R-HSA-1225957 Reactome:R-HSA-1225951 Reactome:R-HSA-1168636	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zimmermann, G et al. (2013) Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497 638-42 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^5.0 ^5.1 Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
↑ Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
↑ Muratcioglu, S et al. (2015) GTP-Dependent K-Ras Dimerization. Structure 23 1325-35 PubMed GONUTS page

[PMID:24623306-1] Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page

[PMID:23698361-2] 2.0 ^2.1 ^2.2 Zimmermann, G et al. (2013) Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497 638-42 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19946888-4] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22065586-5] 5.0 ^5.1 Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page

[PMID:23209302-6] Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page

[PMID:26051715-7] Muratcioglu, S et al. (2015) GTP-Dependent K-Ras Dimerization. Structure 23 1325-35 PubMed GONUTS page

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HUMAN:RASK

Contents

Annotations

Notes

References

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