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HUMAN:RAD17

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RAD17 (synonyms: R24L)
Protein Name(s) Cell cycle checkpoint protein RAD17

hRad17 RF-C/activator 1 homolog

External Links
UniProt O75943
EMBL AF076838
AJ004977
AF112263
AF085736
AJ001642
AJ131296
AJ131297
AJ131298
AJ131299
AJ131300
AJ131301
AJ131302
AJ131303
AJ131304
AJ131305
AJ131306
AJ131307
AJ131308
AF017748
AF126424
AF098533
AF098534
AL122068
AK292487
BX537441
AY612854
CH471137
CH471137
CH471137
CH471137
CH471137
BC032304
CCDS CCDS4003.1
CCDS4004.1
CCDS4005.1
CCDS47226.1
PIR T34548
RefSeq NP_001265551.1
NP_002864.1
NP_579916.1
NP_579917.1
NP_579918.1
NP_579919.1
NP_579920.1
NP_579921.1
NP_579922.1
UniGene Hs.16184
ProteinModelPortal O75943
SMR O75943
BioGrid 111821
DIP DIP-24254N
DIP-34896N
IntAct O75943
MINT MINT-3082919
STRING 9606.ENSP00000370151
PhosphoSite O75943
MaxQB O75943
PaxDb O75943
PRIDE O75943
DNASU 5884
Ensembl ENST00000282891
ENST00000305138
ENST00000345306
ENST00000354312
ENST00000354868
ENST00000358030
ENST00000361732
ENST00000380774
ENST00000509734
ENST00000521422
ENST00000610770
ENST00000611523
ENST00000612044
ENST00000616488
ENST00000616683
ENST00000616759
ENST00000620889
GeneID 5884
KEGG hsa:5884
UCSC uc003jwg.3
uc003jwm.3
uc003jwn.3
CTD 5884
GeneCards GC05P068700
HGNC HGNC:9807
HPA CAB004551
HPA005448
MIM 603139
neXtProt NX_O75943
PharmGKB PA34167
eggNOG COG0470
GeneTree ENSGT00440000039046
HOVERGEN HBG059834
InParanoid O75943
KO K06662
OMA AQIAFIQ
PhylomeDB O75943
Reactome REACT_6769
ChiTaRS RAD17
GeneWiki RAD17
GenomeRNAi 5884
NextBio 22866
PRO PR:O75943
Proteomes UP000005640
UP000005640
Bgee O75943
CleanEx HS_RAD17
ExpressionAtlas O75943
Genevestigator O75943
GO GO:0005654
GO:0005634
GO:0005524
GO:0006974
GO:0000077
GO:0006281
GO:0006260
GO:0000076
GO:0007093
GO:0008156
GO:0042325
Gene3D 3.40.50.300
InterPro IPR003593
IPR004582
IPR018324
IPR027417
PANTHER PTHR12172
SMART SM00382
SUPFAM SSF52540
TIGRFAMs TIGR00602

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042127

regulation of cell proliferation

PMID:14608368[1]

ECO:0000314

P

Figure 1 L shows that phosphorylation at serine 645 is conserved among senescent cells, late population doubling cells, and undamaged proliferating cells.

complete
CACAO 9430

part_of

GO:0005730

nucleolus

PMID:10593953[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000781

chromosome, telomeric region

PMID:15149599[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042325

regulation of phosphorylation

PMID:14657349[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

PMID:14657349[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:15538388[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:15538388[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:15538388[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033314

mitotic DNA replication checkpoint

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000255944
PomBase:SPAC14C4.13

P

Seeded From UniProt

complete

contributes_to

GO:0003689

DNA clamp loader activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000255944
SGD:S000000975

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000255944
PomBase:SPAC14C4.13

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000255944
PomBase:SPAC14C4.13

C

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000255944
SGD:S000000975
UniProtKB:O75943

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NXW6
ensembl:ENSMUSP00000022136

P

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018324

P

Seeded From UniProt

complete

enables

GO:0003689

DNA clamp loader activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018324

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004582
InterPro:IPR018324

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004582
InterPro:IPR018324

P

Seeded From UniProt

complete

part_of

GO:0031389

Rad17 RFC-like complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018324

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:9660800[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9660800[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000076

DNA replication checkpoint

PMID:9660800[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

Reactome:R-HSA-5684887
Reactome:R-HSA-176264
Reactome:R-HSA-176101

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6799332
Reactome:R-HSA-5693580
Reactome:R-HSA-5693564
Reactome:R-HSA-5693561
Reactome:R-HSA-5686657
Reactome:R-HSA-5686642
Reactome:R-HSA-5685156
Reactome:R-HSA-5685011
Reactome:R-HSA-5684887
Reactome:R-HSA-5684882
Reactome:R-HSA-176264
Reactome:R-HSA-176101

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ d'Adda di Fagagna, F et al. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 194-8 PubMed GONUTS page
  2. ↑ Chang, MS et al. (1999) HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. J. Biol. Chem. 274 36544-9 PubMed GONUTS page
  3. ↑ Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
  4. ↑ 4.0 4.1 Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Tsao, CC et al. (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 23 4660-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Parker, AE et al. (1998) Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. J. Biol. Chem. 273 18340-6 PubMed GONUTS page
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