HUMAN:Q9Y5S5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	POLE1 (ECO:0000313 with EMBL:AAD44690.1)
Protein Name(s)	DNA polymerase epsilon catalytic subunit protein isoform a (ECO:0000313 with EMBL:AAD44690.1)
External Links
UniProt	Q9Y5S5
EMBL	AH008000 AF127937 AF127939 AF127940 AF127941 AF127942 AF127943 AF127944 AF127945 AF127947 AF127948 AF127949 AF127950 AF127951 AF127952 AF127953 AF127954 AF127955 AF127956 AF127957 AF127958 AF127959 AF127960 AF127961 AF127962 AF127963 AF127964 AF127965 AF127966 AF127967 AF127968 AF127969 AF127970 AF127971 AF127972 AF127973 AF127974
UniGene	Hs.524871
ProteinModelPortal	Q9Y5S5
STRING	9606.ENSP00000322570
PaxDb	Q9Y5S5
PeptideAtlas	Q9Y5S5
PRIDE	Q9Y5S5
eggNOG	KOG1798 COG0417
HOGENOM	HOG000196287
HOVERGEN	HBG051398
ChiTaRS	POLE
GO	GO:0008622 GO:0008408 GO:0003677 GO:0003887 GO:0000166 GO:0008270 GO:0006281 GO:0006260
Gene3D	3.30.420.10 3.90.1600.10
InterPro	IPR006172 IPR006133 IPR006134 IPR013697 IPR023211 IPR029703 IPR012337
PANTHER	PTHR10670
Pfam	PF00136 PF03104 PF08490
SMART	SM01159 SM00486
SUPFAM	SSF53098

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008622	epsilon DNA polymerase complex	PMID:28423643	ECO:0000314			C		Functions during pre-replication before mRNA splicing occurs.	complete CACAO 12746
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006134 InterPro:IPR006172	F		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006172 InterPro:IPR036397	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006134 InterPro:IPR029703	F		Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006172 InterPro:IPR013697 InterPro:IPR029703	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013697	C		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013697 InterPro:IPR029703	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029703	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013697	F		Seeded From UniProt	complete
part_of	GO:0008622	epsilon DNA polymerase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029703	C		Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.7	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0239	F		Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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