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HUMAN:PTPRU
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PTPRU (synonyms: FMI, PCP2, PTPRO) | |
Protein Name(s) | Receptor-type tyrosine-protein phosphatase U
R-PTP-U Pancreatic carcinoma phosphatase 2 PCP-2 Protein-tyrosine phosphatase J PTP-J hPTP-J Protein-tyrosine phosphatase pi PTP pi Protein-tyrosine phosphatase receptor omicron PTP-RO Receptor-type protein-tyrosine phosphatase psi R-PTP-psi | |
External Links | ||
UniProt | Q92729 | |
EMBL | X95712 X97198 U73727 U71075 U60289 AL645859 AL049570 AL590729 AL645859 AL049570 AL590729 AL590729 AL049570 AL645859 AL590729 AL049570 AL645859 AL049570 AL590729 AL645859 AL049570 AL590729 AL645859 CH471059 CH471059 BC146655 AB208855 | |
CCDS | CCDS334.1 CCDS335.1 CCDS44098.2 CCDS53290.1 | |
PIR | JC5290 S72441 | |
RefSeq | NP_001181930.1 NP_005695.3 NP_573438.3 NP_573439.2 | |
UniGene | Hs.19718 | |
ProteinModelPortal | Q92729 | |
SMR | Q92729 | |
BioGrid | 115386 | |
IntAct | Q92729 | |
MINT | MINT-1349420 | |
ChEMBL | CHEMBL1961785 | |
DEPOD | Q92729 | |
DMDM | 229462800 | |
MaxQB | Q92729 | |
PaxDb | Q92729 | |
PRIDE | Q92729 | |
DNASU | 10076 | |
Ensembl | ENST00000345512 ENST00000373779 ENST00000428026 ENST00000460170 | |
GeneID | 10076 | |
KEGG | hsa:10076 | |
UCSC | uc001bru.3 uc001brw.3 uc009vtq.3 uc009vtr.3 | |
CTD | 10076 | |
GeneCards | GC01P029569 | |
H-InvDB | HIX0000346 | |
HGNC | HGNC:9683 | |
HPA | CAB011476 HPA039832 | |
MIM | 602454 | |
neXtProt | NX_Q92729 | |
PharmGKB | PA34028 | |
eggNOG | COG5599 | |
GeneTree | ENSGT00760000118900 | |
HOVERGEN | HBG062785 | |
InParanoid | Q92729 | |
KO | K16662 | |
OMA | LTDSYTR | |
OrthoDB | EOG70KGNP | |
PhylomeDB | Q92729 | |
TreeFam | TF312900 | |
Reactome | REACT_111040 | |
ChiTaRS | PTPRU | |
GeneWiki | PTPRU | |
GenomeRNAi | 10076 | |
NextBio | 38089 | |
PRO | PR:Q92729 | |
Proteomes | UP000005640 | |
Bgee | Q92729 | |
CleanEx | HS_PCP2 HS_PTPRU | |
ExpressionAtlas | Q92729 | |
Genevestigator | Q92729 | |
GO | GO:0005911 GO:0005887 GO:0005886 GO:0008013 GO:0004725 GO:0005001 GO:0060070 GO:0007155 GO:0030154 GO:0034109 GO:0030336 GO:0008285 GO:0031100 GO:0035335 GO:0006470 GO:0034394 GO:0051384 GO:0016337 GO:0007185 | |
Gene3D | 2.60.40.10 3.90.190.10 | |
InterPro | IPR013320 IPR003961 IPR013783 IPR003599 IPR000998 IPR029021 IPR000387 IPR016130 IPR000242 | |
Pfam | PF00041 PF00629 PF00102 | |
PRINTS | PR00020 PR00700 | |
SMART | SM00060 SM00409 SM00137 SM00194 | |
SUPFAM | SSF49265 SSF49899 SSF52799 | |
PROSITE | PS50853 PS00740 PS50060 PS00383 PS50056 PS50055 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Contributes to |
GO:0016791 |
phosphatase activity |
ECO:0000314 |
F |
Figure 4: PTPRU genes in astrocytes were identified as key genes affecting HSV-1 replication. |
complete | ||||
involved_in |
GO:0034394 |
protein localization to cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000049 |
positive regulation of cell-cell adhesion mediated by cadherin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007185 |
transmembrane receptor protein tyrosine phosphatase signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005001 |
transmembrane receptor protein tyrosine phosphatase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P35222) |
Seeded From UniProt |
complete | ||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005001 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034109 |
homotypic cell-cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1AUH1 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1AUH1 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1MAG7 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031100 |
animal organ regeneration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1MAG7 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-1433423 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Yan, HX et al. (2006) Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J. Biol. Chem. 281 15423-33 PubMed GONUTS page
- ↑ Yue, L et al. (2013) The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes. PLoS ONE 8 e79648 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Yan, HX et al. (2002) Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. Biochemistry 41 15854-60 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Wang, H et al. (1996) Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. Oncogene 12 2555-62 PubMed GONUTS page
c
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n
p
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- GO:2000049 ! positive regulation of cell-cell adhesion mediated by cadherin
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0034394 ! protein localization to cell surface
- GO:0004725 ! protein tyrosine phosphatase activity