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HUMAN:PTPRU

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PTPRU (synonyms: FMI, PCP2, PTPRO)
Protein Name(s) Receptor-type tyrosine-protein phosphatase U

R-PTP-U Pancreatic carcinoma phosphatase 2 PCP-2 Protein-tyrosine phosphatase J PTP-J hPTP-J Protein-tyrosine phosphatase pi PTP pi Protein-tyrosine phosphatase receptor omicron PTP-RO Receptor-type protein-tyrosine phosphatase psi R-PTP-psi

External Links
UniProt Q92729
EMBL X95712
X97198
U73727
U71075
U60289
AL645859
AL049570
AL590729
AL645859
AL049570
AL590729
AL590729
AL049570
AL645859
AL590729
AL049570
AL645859
AL049570
AL590729
AL645859
AL049570
AL590729
AL645859
CH471059
CH471059
BC146655
AB208855
CCDS CCDS334.1
CCDS335.1
CCDS44098.2
CCDS53290.1
PIR JC5290
S72441
RefSeq NP_001181930.1
NP_005695.3
NP_573438.3
NP_573439.2
UniGene Hs.19718
ProteinModelPortal Q92729
SMR Q92729
BioGrid 115386
IntAct Q92729
MINT MINT-1349420
ChEMBL CHEMBL1961785
DEPOD Q92729
DMDM 229462800
MaxQB Q92729
PaxDb Q92729
PRIDE Q92729
DNASU 10076
Ensembl ENST00000345512
ENST00000373779
ENST00000428026
ENST00000460170
GeneID 10076
KEGG hsa:10076
UCSC uc001bru.3
uc001brw.3
uc009vtq.3
uc009vtr.3
CTD 10076
GeneCards GC01P029569
H-InvDB HIX0000346
HGNC HGNC:9683
HPA CAB011476
HPA039832
MIM 602454
neXtProt NX_Q92729
PharmGKB PA34028
eggNOG COG5599
GeneTree ENSGT00760000118900
HOVERGEN HBG062785
InParanoid Q92729
KO K16662
OMA LTDSYTR
OrthoDB EOG70KGNP
PhylomeDB Q92729
TreeFam TF312900
Reactome REACT_111040
ChiTaRS PTPRU
GeneWiki PTPRU
GenomeRNAi 10076
NextBio 38089
PRO PR:Q92729
Proteomes UP000005640
Bgee Q92729
CleanEx HS_PCP2
HS_PTPRU
ExpressionAtlas Q92729
Genevestigator Q92729
GO GO:0005911
GO:0005887
GO:0005886
GO:0008013
GO:0004725
GO:0005001
GO:0060070
GO:0007155
GO:0030154
GO:0034109
GO:0030336
GO:0008285
GO:0031100
GO:0035335
GO:0006470
GO:0034394
GO:0051384
GO:0016337
GO:0007185
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR013320
IPR003961
IPR013783
IPR003599
IPR000998
IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00041
PF00629
PF00102
PRINTS PR00020
PR00700
SMART SM00060
SM00409
SM00137
SM00194
SUPFAM SSF49265
SSF49899
SSF52799
PROSITE PS50853
PS00740
PS50060
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:16574648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

Contributes to

GO:0016791

phosphatase activity

PMID:24260274[2]

ECO:0000314

F

Figure 4: PTPRU genes in astrocytes were identified as key genes affecting HSV-1 replication.

complete
CACAO 9369

involved_in

GO:0034394

protein localization to cell surface

PMID:16574648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:12501215[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:16574648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000049

positive regulation of cell-cell adhesion mediated by cadherin

PMID:16574648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:16574648[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

PMID:16574648[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35222

F

Seeded From UniProt

complete

involved_in

GO:0007185

transmembrane receptor protein tyrosine phosphatase signaling pathway

PMID:8700514[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:8700514[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

PMID:12501215[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:12501215[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8700514[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

PMID:8700514[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:16574648[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(UniProtKB:P35222)

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:12501215[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005001

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0034109

homotypic cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B1AUH1
ensembl:ENSMUSP00000030741

P

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B1AUH1
ensembl:ENSMUSP00000030741

F

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG7
ensembl:ENSRNOP00000030956

P

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1MAG7
ensembl:ENSRNOP00000030956

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000998

C

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1433423

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965
UniProtKB-SubCell:SL-0038

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Yan, HX et al. (2006) Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J. Biol. Chem. 281 15423-33 PubMed GONUTS page
  2. Yue, L et al. (2013) The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes. PLoS ONE 8 e79648 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Yan, HX et al. (2002) Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. Biochemistry 41 15854-60 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Wang, H et al. (1996) Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. Oncogene 12 2555-62 PubMed GONUTS page