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HUMAN:PTPRH
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PTPRH (synonyms: SAP1) | |
| Protein Name(s) | Receptor-type tyrosine-protein phosphatase H
R-PTP-H Stomach cancer-associated protein tyrosine phosphatase 1 SAP-1 Transmembrane-type protein-tyrosine phosphatase type H | |
| External Links | ||
| UniProt | Q9HD43 | |
| EMBL | D15049 AF275150 AF275131 AF275132 AF275133 AF275134 AF275135 AF275136 AF275137 AF275138 AF275139 AF275140 AF275141 AF275142 AF275143 AF275144 AF275145 AF275146 AF275147 AF275148 AF275149 AC010327 BC111715 BC111716 | |
| CCDS | CCDS33110.1 CCDS54321.1 | |
| PIR | A49724 | |
| UniGene | Hs.179770 | |
| ProteinModelPortal | Q9HD43 | |
| SMR | Q9HD43 | |
| IntAct | Q9HD43 | |
| MINT | MINT-1349530 | |
| STRING | 9606.ENSP00000365528 | |
| DEPOD | Q9HD43 | |
| iPTMnet | Q9HD43 | |
| PhosphoSitePlus | Q9HD43 | |
| BioMuta | PTPRH | |
| DMDM | 296452983 | |
| MaxQB | Q9HD43 | |
| PaxDb | Q9HD43 | |
| PeptideAtlas | Q9HD43 | |
| PRIDE | Q9HD43 | |
| Ensembl | ENST00000263434 ENST00000376350 | |
| UCSC | uc002qjq.4 | |
| DisGeNET | 5794 | |
| GeneCards | PTPRH | |
| HGNC | HGNC:9672 | |
| HPA | HPA042300 | |
| MIM | 602510 | |
| neXtProt | NX_Q9HD43 | |
| PharmGKB | PA34017 | |
| eggNOG | KOG0791 COG5599 | |
| HOGENOM | HOG000170539 | |
| HOVERGEN | HBG108307 | |
| InParanoid | Q9HD43 | |
| OrthoDB | EOG091G08FR | |
| PhylomeDB | Q9HD43 | |
| TreeFam | TF351926 | |
| BioCyc | ZFISH:HS01346-MONOMER | |
| BRENDA | 3.1.3.48 | |
| SIGNOR | Q9HD43 | |
| PRO | PR:Q9HD43 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000080031 | |
| CleanEx | HS_PTPRH | |
| Genevisible | Q9HD43 | |
| GO | GO:0016324 GO:0005737 GO:0005887 GO:0031528 GO:0005001 GO:0006915 GO:0006470 | |
| CDD | cd00063 | |
| Gene3D | 2.60.40.10 3.90.190.10 | |
| InterPro | IPR003961 IPR013783 IPR029021 IPR000242 IPR028855 IPR016130 IPR003595 IPR000387 | |
| PANTHER | PTHR19134:SF297 | |
| Pfam | PF00041 PF00102 | |
| PRINTS | PR00700 | |
| SMART | SM00060 SM00194 SM00404 | |
| SUPFAM | SSF49265 SSF52799 | |
| PROSITE | PS50853 PS00383 PS50056 PS50055 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005001 |
P |
Seeded From UniProt |
complete | ||
| GO:1990264 |
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
ECO:0000314 |
P |
Figure 2B and 2C: Ptprh dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells |
complete | |||||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005001 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005001 |
transmembrane receptor protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005001 |
transmembrane receptor protein tyrosine phosphatase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031528 |
microvillus membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Matozaki, T et al. (1994) Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers. J. Biol. Chem. 269 2075-81 PubMed GONUTS page
p
- GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0004725 ! protein tyrosine phosphatase activity
