GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:PTPRB
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PTPRB (synonyms: PTPB) | |
| Protein Name(s) | Receptor-type tyrosine-protein phosphatase beta
Protein-tyrosine phosphatase beta R-PTP-beta Vascular endothelial protein tyrosine phosphatase VE-PTP | |
| External Links | ||
| UniProt | P23467 | |
| EMBL | X54131 BX648245 AC025569 AC083809 CH471054 BC101679 BC113463 BC143356 BC143360 | |
| CCDS | CCDS44943.1 CCDS44944.1 CCDS55845.1 CCDS55846.1 | |
| PIR | S12050 | |
| RefSeq | NP_001103224.1 NP_001193900.1 NP_001193901.1 NP_001317133.1 NP_002828.3 | |
| UniGene | Hs.201030 Hs.434375 | |
| PDB | 2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X | |
| PDBsum | 2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X | |
| ProteinModelPortal | P23467 | |
| SMR | P23467 | |
| BioGrid | 111751 | |
| IntAct | P23467 | |
| MINT | MINT-1349770 | |
| STRING | 9606.ENSP00000334928 | |
| BindingDB | P23467 | |
| ChEMBL | CHEMBL2706 | |
| GuidetoPHARMACOLOGY | 1851 | |
| DEPOD | P23467 | |
| iPTMnet | P23467 | |
| PhosphoSitePlus | P23467 | |
| BioMuta | PTPRB | |
| DMDM | 317373518 | |
| MaxQB | P23467 | |
| PaxDb | P23467 | |
| PeptideAtlas | P23467 | |
| PRIDE | P23467 | |
| Ensembl | ENST00000261266 ENST00000334414 ENST00000538708 ENST00000550857 | |
| GeneID | 5787 | |
| KEGG | hsa:5787 | |
| UCSC | uc001swb.6 | |
| CTD | 5787 | |
| DisGeNET | 5787 | |
| GeneCards | PTPRB | |
| H-InvDB | HIX0017674 HIX0037045 | |
| HGNC | HGNC:9665 | |
| HPA | CAB004782 | |
| MIM | 176882 | |
| neXtProt | NX_P23467 | |
| OpenTargets | ENSG00000127329 | |
| PharmGKB | PA34010 | |
| eggNOG | KOG0791 COG5599 | |
| GeneTree | ENSGT00770000120452 | |
| HOGENOM | HOG000060224 | |
| HOVERGEN | HBG053759 | |
| InParanoid | P23467 | |
| KO | K05694 | |
| OMA | RVYQTNY | |
| OrthoDB | EOG091G00JF | |
| PhylomeDB | P23467 | |
| TreeFam | TF351926 | |
| BioCyc | ZFISH:HS05085-MONOMER | |
| BRENDA | 3.1.3.48 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-6798695 R-HSA-6798695] | |
| SignaLink | P23467 | |
| SIGNOR | P23467 | |
| ChiTaRS | PTPRB | |
| EvolutionaryTrace | P23467 | |
| GeneWiki | PTPRB | |
| GenomeRNAi | 5787 | |
| PRO | PR:P23467 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000127329 | |
| CleanEx | HS_PTPRB | |
| ExpressionAtlas | P23467 | |
| Genevisible | P23467 | |
| GO | GO:0005887 GO:0043235 GO:0005001 GO:0001525 GO:0016311 GO:0006796 GO:0006470 | |
| CDD | cd00063 | |
| Gene3D | 2.60.40.10 3.90.190.10 | |
| InterPro | IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387 | |
| Pfam | PF00041 PF00102 | |
| PRINTS | PR00700 | |
| SMART | SM00060 SM00194 SM00404 | |
| SUPFAM | SSF49265 SSF52799 | |
| PROSITE | PS50853 PS00383 PS50056 PS50055 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005001 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RU80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2RU80 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
| GO:1990264 |
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
ECO:0000314 |
P |
Figure 2B and 2C: Ptprb dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells |
complete | |||||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006796 |
phosphate-containing compound metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005001 |
transmembrane receptor protein tyrosine phosphatase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070821 |
tertiary granule membrane |
Reactome:R-HSA-6798747 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035579 |
specific granule membrane |
Reactome:R-HSA-6799350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6799350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yacyshyn, OK et al. (2009) Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. Angiogenesis 12 25-33 PubMed GONUTS page
- ↑ Mellberg, S et al. (2009) Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J. 23 1490-502 PubMed GONUTS page
- ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
- ↑ Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Krueger, NX et al. (1990) Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9 3241-52 PubMed GONUTS page
p
- GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0006796 ! phosphate-containing compound metabolic process
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0004725 ! protein tyrosine phosphatase activity
t
