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Cacao

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GO:1990264peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityPMID:26063811IDA: Inferred from Direct Assay P
This annotation made on page: HUMAN:PTPRB
By: CSears (group Team Girl, you trypsin) on 2017-02-14 13:50:19 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeTheBockster,
Team Daytona Bronze Viper
2017-03-28 14:26:57 CDT

The GO term and the Figure used do not quite match correctly here. Specifically, this GO term requires that dephosphorylation be linked to the inactivation of protein kinase activity. While that is proven in this paper it is NOT proven by Figure 1, and is instead proven later in the paper. If the Figure used was changed, this specific GO term could be used. It would ALSO be acceptable to simply use a less specific GO term. I suggest doing the latter. Therefore, I propose that the GO term used for this annotation should be GO:0035335 (peptidyl-tyrosine dephosphorylation). Just to be safe, I would also like to note that the long name of the protein (according to UniProt) is Receptor-type tyrosine-protein phosphatase beta and the corresponding organism is Homo sapiens.

None, yet.
ChallengeSarahCouv,
Team Lily Whale
2017-02-24 15:44:53 CST

The protein is incorrect for this annotation. The correct protein is B2RU80 (PTPRB_MOUSE).

1
Private
Assessment
Suzialeksander2017-04-25 05:01:12 CDTYou need to be an instructor to view these notes.Unacceptable
Unique/Original
Public
Assessment
DanielRenfro2017-04-04 13:17:33 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity PMID:26063811 IDA: Inferred from Direct Assay P Figure 2B and 2C: Ptprb dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells complete
CACAO 12261
on HUMAN:PTPRB
Flagged
Public
Assessment
DanielRenfro2017-03-28 14:26:57 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Suzialeksander2017-03-03 15:22:49 CSTYou need to be an instructor to view these notes.Requires Changes
Publication
Qualifier
Go term
Evidence
With/From
Notes
Public
Assessment
DanielRenfro2017-02-24 15:44:53 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Sandyl 272017-02-23 12:38:32 CSTYou need to be an instructor to view these notes.Requires Changes
Protein