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HUMAN:PTN13

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PTPN13 (synonyms: PNP1, PTP1E, PTPL1)
Protein Name(s) Tyrosine-protein phosphatase non-receptor type 13

Fas-associated protein-tyrosine phosphatase 1 FAP-1 PTP-BAS Protein-tyrosine phosphatase 1E PTP-E1 hPTPE1 Protein-tyrosine phosphatase PTPL1

External Links
UniProt Q12923
EMBL U12128
D21209
D21210
D21211
X80289
BC039610
BC140777
X79676
L34583
AF233323
CCDS CCDS47093.1
CCDS47094.1
CCDS47095.1
CCDS47096.1
PIR A54971
I67629
I67630
RefSeq NP_006255.1
NP_542414.1
NP_542415.1
NP_542416.1
UniGene Hs.436142
PDB 1D5G
1Q7X
1WCH
2M0Z
2M10
3LNX
3LNY
3PDZ
PDBsum 1D5G
1Q7X
1WCH
2M0Z
2M10
3LNX
3LNY
3PDZ
ProteinModelPortal Q12923
SMR Q12923
BioGrid 111747
DIP DIP-40449N
IntAct Q12923
MINT MINT-109571
BindingDB Q12923
ChEMBL CHEMBL2976
DEPOD Q12923
PhosphoSite Q12923
DMDM 12643716
MaxQB Q12923
PaxDb Q12923
PRIDE Q12923
DNASU 5783
Ensembl ENST00000316707
ENST00000411767
ENST00000427191
ENST00000436978
ENST00000511467
GeneID 5783
KEGG hsa:5783
UCSC uc003hpy.3
uc003hpz.3
uc003hqa.3
uc003hqb.3
CTD 5783
GeneCards GC04P087515
HGNC HGNC:9646
HPA CAB002213
MIM 600267
neXtProt NX_Q12923
PharmGKB PA33988
eggNOG COG5599
GeneTree ENSGT00770000120472
HOVERGEN HBG053756
InParanoid Q12923
KO K02374
OMA GCYVHDV
OrthoDB EOG7K9K22
PhylomeDB Q12923
TreeFam TF315388
ChiTaRS PTPN13
EvolutionaryTrace Q12923
GeneWiki PTPN13
GenomeRNAi 5783
NextBio 22492
PRO PR:Q12923
Proteomes UP000005640
Bgee Q12923
ExpressionAtlas Q12923
Genevestigator Q12923
GO GO:0044297
GO:0005737
GO:0005856
GO:0070062
GO:0030027
GO:0043005
GO:0005634
GO:0005886
GO:0036312
GO:0004725
GO:0035335
GO:0014066
Gene3D 1.20.80.10
2.30.29.30
2.30.42.10
3.90.190.10
InterPro IPR019749
IPR014352
IPR019748
IPR000299
IPR018979
IPR018980
IPR011019
IPR001478
IPR011993
IPR029021
IPR012153
IPR000387
IPR000242
IPR029071
PANTHER PTHR19134:SF197
Pfam PF09380
PF00373
PF09379
PF00595
PF00102
PIRSF PIRSF000933
PRINTS PR00935
PR00700
SMART SM00295
SM00750
SM00228
SM00194
SUPFAM SSF47031
SSF50156
SSF52799
SSF54236
PROSITE PS50057
PS51377
PS50106
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:25893857[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

PMID:17657516[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q9BUL8)|has_input:(UniProtKB:O00506)

Seeded From UniProt

complete

enables

GO:0036312

phosphatidylinositol 3-kinase regulatory subunit binding

PMID:23604317[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00459

F

Seeded From UniProt

complete

involved_in

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

PMID:23604317[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:23604317[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:23604317[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

PMID:11356191[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14516276[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14516276[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11356191[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:14516276[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:15611135[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0044297

cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V9S3
ensembl:ENSRNOP00000057876

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V9S3
ensembl:ENSRNOP00000057876

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR012153

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000299

C

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR012153

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

Reactome:R-HSA-9008059

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006661

phosphatidylinositol biosynthetic process

Reactome:R-HSA-1660499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8870332

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9008894

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0291

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page
  2. ↑ Voss, K et al. (2007) CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics 8 249-56 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Kuchay, S et al. (2013) FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nat. Cell Biol. 15 472-80 PubMed GONUTS page
  4. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. ↑ 5.0 5.1 Gross, C et al. (2001) The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. FEBS Lett. 496 101-4 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Kimber, WA et al. (2003) Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Biochem. J. 376 525-35 PubMed GONUTS page
  7. ↑ Villa, F et al. (2005) Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. J. Biol. Chem. 280 8180-7 PubMed GONUTS page
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