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HUMAN:PTN13
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PTPN13 (synonyms: PNP1, PTP1E, PTPL1) | |
Protein Name(s) | Tyrosine-protein phosphatase non-receptor type 13
Fas-associated protein-tyrosine phosphatase 1 FAP-1 PTP-BAS Protein-tyrosine phosphatase 1E PTP-E1 hPTPE1 Protein-tyrosine phosphatase PTPL1 | |
External Links | ||
UniProt | Q12923 | |
EMBL | U12128 D21209 D21210 D21211 X80289 BC039610 BC140777 X79676 L34583 AF233323 | |
CCDS | CCDS47093.1 CCDS47094.1 CCDS47095.1 CCDS47096.1 | |
PIR | A54971 I67629 I67630 | |
RefSeq | NP_006255.1 NP_542414.1 NP_542415.1 NP_542416.1 | |
UniGene | Hs.436142 | |
PDB | 1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ | |
PDBsum | 1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ | |
ProteinModelPortal | Q12923 | |
SMR | Q12923 | |
BioGrid | 111747 | |
DIP | DIP-40449N | |
IntAct | Q12923 | |
MINT | MINT-109571 | |
BindingDB | Q12923 | |
ChEMBL | CHEMBL2976 | |
DEPOD | Q12923 | |
PhosphoSite | Q12923 | |
DMDM | 12643716 | |
MaxQB | Q12923 | |
PaxDb | Q12923 | |
PRIDE | Q12923 | |
DNASU | 5783 | |
Ensembl | ENST00000316707 ENST00000411767 ENST00000427191 ENST00000436978 ENST00000511467 | |
GeneID | 5783 | |
KEGG | hsa:5783 | |
UCSC | uc003hpy.3 uc003hpz.3 uc003hqa.3 uc003hqb.3 | |
CTD | 5783 | |
GeneCards | GC04P087515 | |
HGNC | HGNC:9646 | |
HPA | CAB002213 | |
MIM | 600267 | |
neXtProt | NX_Q12923 | |
PharmGKB | PA33988 | |
eggNOG | COG5599 | |
GeneTree | ENSGT00770000120472 | |
HOVERGEN | HBG053756 | |
InParanoid | Q12923 | |
KO | K02374 | |
OMA | GCYVHDV | |
OrthoDB | EOG7K9K22 | |
PhylomeDB | Q12923 | |
TreeFam | TF315388 | |
ChiTaRS | PTPN13 | |
EvolutionaryTrace | Q12923 | |
GeneWiki | PTPN13 | |
GenomeRNAi | 5783 | |
NextBio | 22492 | |
PRO | PR:Q12923 | |
Proteomes | UP000005640 | |
Bgee | Q12923 | |
ExpressionAtlas | Q12923 | |
Genevestigator | Q12923 | |
GO | GO:0044297 GO:0005737 GO:0005856 GO:0070062 GO:0030027 GO:0043005 GO:0005634 GO:0005886 GO:0036312 GO:0004725 GO:0035335 GO:0014066 | |
Gene3D | 1.20.80.10 2.30.29.30 2.30.42.10 3.90.190.10 | |
InterPro | IPR019749 IPR014352 IPR019748 IPR000299 IPR018979 IPR018980 IPR011019 IPR001478 IPR011993 IPR029021 IPR012153 IPR000387 IPR000242 IPR029071 | |
PANTHER | PTHR19134:SF197 | |
Pfam | PF09380 PF00373 PF09379 PF00595 PF00102 | |
PIRSF | PIRSF000933 | |
PRINTS | PR00935 PR00700 | |
SMART | SM00295 SM00750 SM00228 SM00194 | |
SUPFAM | SSF47031 SSF50156 SSF52799 SSF54236 | |
PROSITE | PS50057 PS51377 PS50106 PS50056 PS50055 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q9BUL8)|has_input:(UniProtKB:O00506) |
Seeded From UniProt |
complete | ||
enables |
GO:0036312 |
phosphatidylinositol 3-kinase regulatory subunit binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0044297 |
cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V9S3 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V9S3 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
Reactome:R-HSA-9008059 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006661 |
phosphatidylinositol biosynthetic process |
Reactome:R-HSA-1660499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8870332 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-9008894 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page
- ↑ Voss, K et al. (2007) CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics 8 249-56 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kuchay, S et al. (2013) FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nat. Cell Biol. 15 472-80 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 5.0 5.1 Gross, C et al. (2001) The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. FEBS Lett. 496 101-4 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kimber, WA et al. (2003) Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Biochem. J. 376 525-35 PubMed GONUTS page
- ↑ Villa, F et al. (2005) Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. J. Biol. Chem. 280 8180-7 PubMed GONUTS page
c
n
p
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0006661 ! phosphatidylinositol biosynthetic process
- GO:0036312 ! phosphatidylinositol 3-kinase regulatory subunit binding
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- Primates
- GO:0006470 ! protein dephosphorylation
- GO:0004725 ! protein tyrosine phosphatase activity