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HUMAN:PRM2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRM2
Protein Name(s) Protamine-2

Sperm histone P2 Sperm protamine P2 Basic nuclear protein HPI1 Basic nuclear protein HPI2 Basic nuclear protein HPS1 Basic nuclear protein HPS2 Sperm histone HP4 Sperm protamine P4 Sperm histone HP2 Sperm protamine P2 P2' Sperm histone HP3 P2 Sperm protamine P3

External Links
UniProt P04554
EMBL X07862
M60332
Z46940
U15422
AF215713
AK131573
AC009121
BC005303
BC066338
CCDS CCDS42118.1
CCDS66944.1
PIR B38515
RefSeq NP_001273285.1
NP_001273287.1
NP_001273288.1
NP_002753.2
UniGene Hs.2324
PDB 2AWR
PDBsum 2AWR
ProteinModelPortal P04554
IntAct P04554
STRING 9606.ENSP00000241808
PhosphoSite P04554
DMDM 123700
PRIDE P04554
DNASU 5620
Ensembl ENST00000241808
ENST00000435245
GeneID 5620
KEGG hsa:5620
UCSC uc002dau.1
CTD 5620
GeneCards GC16M011369
HGNC HGNC:9448
HPA CAB032738
HPA056386
MIM 182882
182890
neXtProt NX_P04554
PharmGKB PA33793
eggNOG NOG44137
GeneTree ENSGT00730000111973
HOGENOM HOG000143619
HOVERGEN HBG082177
InParanoid P04554
OMA HVEVYER
OrthoDB EOG7SXW6X
TreeFam TF338206
GenomeRNAi 5620
NextBio 21840
PRO PR:P04554
Proteomes UP000005640
Bgee P04554
CleanEx HS_PRM2
ExpressionAtlas P04554
Genevestigator P04554
GO GO:0005654
GO:0000786
GO:0005634
GO:0003677
GO:0030154
GO:0030261
GO:0006323
GO:0007275
GO:0007283
InterPro IPR000492
PANTHER PTHR21341
Pfam PF00841

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0046870

cadmium ion binding

PMID:2243113[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:2243113[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07978

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97766
PANTHER:PTN000482059

P

Seeded From UniProt

complete

involved_in

GO:0006997

nucleus organization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97766
PANTHER:PTN000482059

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97766
PANTHER:PTN000482059
UniProtKB:P19757

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000492

F

Seeded From UniProt

complete

involved_in

GO:0006323

DNA packaging

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000492

P

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000492

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:2081589[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006323

DNA packaging

PMID:2081589[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:2081589[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:2081589[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0030261

chromosome condensation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0226

P

Seeded From UniProt

complete

part_of

GO:0000786

nucleosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0544

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Gatewood, JM et al. (1990) Zinc-induced secondary structure transitions in human sperm protamines. J. Biol. Chem. 265 20667-72 PubMed GONUTS page
  2. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Domenjoud, L et al. (1990) Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered. Genomics 8 127-33 PubMed GONUTS page