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HUMAN:PRL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRL
Protein Name(s) Prolactin

PRL

External Links
UniProt P01236
EMBL V00566
X00540
X00541
X00543
X00544
X54393
X54393
BC015850
M29386
D00411
U75583
CCDS CCDS4548.1
PIR A61402
A90998
RefSeq NP_000939.1
NP_001157030.1
UniGene Hs.1905
Hs.735971
PDB 1RW5
2Q98
3D48
3EW3
3MZG
3N06
3N0P
3NCB
3NCC
3NCE
3NCF
3NPZ
PDBsum 1RW5
2Q98
3D48
3EW3
3MZG
3N06
3N0P
3NCB
3NCC
3NCE
3NCF
3NPZ
ProteinModelPortal P01236
SMR P01236
BioGrid 111602
DIP DIP-59635N
IntAct P01236
STRING 9606.ENSP00000302150
PhosphoSite P01236
PaxDb P01236
PRIDE P01236
DNASU 5617
Ensembl ENST00000306482
GeneID 5617
KEGG hsa:5617
UCSC uc003ndp.3
CTD 5617
GeneCards GC06M022230
HGNC HGNC:9445
HPA CAB023353
MIM 176760
neXtProt NX_P01236
PharmGKB PA33790
eggNOG NOG47376
HOGENOM HOG000264241
HOVERGEN HBG104895
InParanoid P01236
KO K05439
OMA LHCLRRD
OrthoDB EOG74FF24
PhylomeDB P01236
TreeFam TF332592
Reactome REACT_111133
REACT_115697
REACT_75925
SignaLink P01236
ChiTaRS PRL
EvolutionaryTrace P01236
GeneWiki Prolactin
GenomeRNAi 5617
NextBio 21828
PMAP-CutDB P01236
PRO PR:P01236
Proteomes UP000005640
Bgee P01236
CleanEx HS_PRL
ExpressionAtlas P01236
Genevestigator P01236
GO GO:0005576
GO:0005148
GO:0008283
GO:0007166
GO:0007565
GO:0060397
GO:0007595
GO:0046427
GO:0040014
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR001400
IPR018116
PANTHER PTHR11417
Pfam PF00103
PRINTS PR00836
SUPFAM SSF47266
PROSITE PS00266
PS00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0016525

negative regulation of angiogenesis

PMID:23619365[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

PMID:23619365[1]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSG00000283733)
  • part_of:(GO:0038061)
  • occurs_in:(CL:0000071)

Seeded From UniProt

complete

involved_in

GO:0001937

negative regulation of endothelial cell proliferation

PMID:23619365[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:7221563[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:12552091[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0040014

regulation of multicellular organism growth

PMID:8421089[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903489

positive regulation of lactation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
UniProtKB:P01239

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151829
UniProtKB:P01236
UniProtKB:P01241

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151829
UniProtKB:P01246

P

Seeded From UniProt

complete

involved_in

GO:0030879

mammary gland development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151833

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97762
PANTHER:PTN000151831
RGD:2428
RGD:3403

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
RGD:2516
RGD:708348

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:1858413
MGI:MGI:95707
MGI:MGI:97606
MGI:MGI:97607
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2429
RGD:2686
UniProtKB:P01238
UniProtKB:P01239
UniProtKB:P01241
UniProtKB:P01246
UniProtKB:P08998
UniProtKB:P14676

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2686

F

Seeded From UniProt

complete

enables

GO:0005148

prolactin receptor binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
RGD:2428

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

C

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:10854700[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005148

prolactin receptor binding

PMID:10854700[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060397

growth hormone receptor signaling pathway via JAK-STAT

Reactome:R-HSA-982772

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031904

endosome lumen

Reactome:R-HSA-1170539

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-982810
Reactome:R-HSA-977136
Reactome:R-HSA-976991
Reactome:R-HSA-976734
Reactome:R-HSA-1675473
Reactome:R-HSA-1671687
Reactome:R-HSA-1370505
Reactome:R-HSA-1370500
Reactome:R-HSA-1170539

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007595

lactation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0421

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Halkein, J et al. (2013) MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J. Clin. Invest. 123 2143-54 PubMed GONUTS page
  2. ↑ Owerbach, D et al. (1981) The prolactin gene is located on chromosome 6 in humans. Science 212 815-6 PubMed GONUTS page
  3. ↑ Leung, KC et al. (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc. Natl. Acad. Sci. U.S.A. 100 1016-21 PubMed GONUTS page
  4. ↑ Zimmerman, D et al. (1993) Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. J. Clin. Endocrinol. Metab. 76 216-22 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 Hotakainen, PK et al. (2000) Expression of luteinising hormone and chorionic gonadotropin beta-subunit messenger-RNA and protein in human peripheral blood leukocytes. Mol. Cell. Endocrinol. 162 79-85 PubMed GONUTS page
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