HUMAN:PPM1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PPM1A (synonyms: PPPM1A)
Protein Name(s)	Protein phosphatase 1A Protein phosphatase 2C isoform alpha PP2C-alpha Protein phosphatase IA
External Links
UniProt	P35813
EMBL	S87759 AF070670 AK097843 AB451247 AL132778 AL157756 CH471061 BC026691 BC063243
CCDS	CCDS45120.1 CCDS9744.1 CCDS9745.1
PIR	S22423
RefSeq	NP_066283.1 NP_808820.1 NP_808821.2 XP_005267836.1 XP_005267838.1 XP_011535180.1 XP_011535181.1 XP_011535182.1 XP_011535183.1 XP_011535184.1 XP_011535185.1 XP_011535186.1 XP_016876873.1 XP_016876874.1 XP_016876875.1 XP_016876876.1
UniGene	Hs.130036
PDB	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG
PDBsum	1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG
ProteinModelPortal	P35813
SMR	P35813
BioGrid	111489
IntAct	P35813
MINT	P35813
STRING	9606.ENSP00000327255
BindingDB	P35813
ChEMBL	CHEMBL2437
DEPOD	P35813
iPTMnet	P35813
PhosphoSitePlus	P35813
BioMuta	PPM1A
DMDM	548442
EPD	P35813
MaxQB	P35813
PaxDb	P35813
PeptideAtlas	P35813
PRIDE	P35813
DNASU	5494
Ensembl	ENST00000325642 ENST00000325658 ENST00000395076
GeneID	5494
KEGG	hsa:5494
UCSC	uc001xew.5
CTD	5494
DisGeNET	5494
EuPathDB	HostDB:ENSG00000100614.17
GeneCards	PPM1A
HGNC	HGNC:9275
HPA	HPA029209
MIM	606108
neXtProt	NX_P35813
OpenTargets	ENSG00000100614
PharmGKB	PA33603
eggNOG	KOG0697 COG0631
GeneTree	ENSGT00880000137909
HOGENOM	HOG000233895
HOVERGEN	HBG053647
InParanoid	P35813
KO	K04457
OMA	VMSGRVN
OrthoDB	EOG091G0AJQ
PhylomeDB	P35813
TreeFam	TF313590
BRENDA	3.1.3.16
Reactome	R-HSA-2173795 R-HSA-380972
SABIO-RK	P35813
SignaLink	P35813
SIGNOR	P35813
ChiTaRS	PPM1A
EvolutionaryTrace	P35813
GeneWiki	PPM1A
GenomeRNAi	5494
PRO	PR:P35813
Proteomes	UP000005640
Bgee	ENSG00000100614
CleanEx	HS_PPM1A
ExpressionAtlas	P35813
Genevisible	P35813
GO	GO:0005829 GO:0016020 GO:0005654 GO:0005634 GO:0005886 GO:0033192 GO:0000287 GO:0030145 GO:0004722 GO:0070412 GO:0004871 GO:0007050 GO:0071560 GO:0016311 GO:0006499 GO:0030514 GO:0043124 GO:0042347 GO:0010991 GO:0000122 GO:0030512 GO:0035970 GO:0043123 GO:0046827 GO:0045893 GO:0030177 GO:0006470 GO:0016055
CDD	cd00143
Gene3D	1.10.10.430 3.60.40.10
InterPro	IPR015655 IPR000222 IPR012911 IPR036580 IPR036457 IPR001932
PANTHER	PTHR13832
Pfam	PF00481 PF07830
SMART	SM00332
SUPFAM	SSF81601 SSF81606
PROSITE	PS01032 PS51746

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10644691^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:10644691^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	PMID:10644691^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:16751101^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18930133^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[4]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PMID:18930133^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035970	peptidyl-threonine dephosphorylation	PMID:11559703^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8N5S9)	Seeded From UniProt	complete
involved_in	GO:0035970	peptidyl-threonine dephosphorylation	PMID:20801214^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q13131)	Seeded From UniProt	complete
enables	GO:0033192	calmodulin-dependent protein phosphatase activity	PMID:11559703^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:16751101^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49443	C		Seeded From UniProt	complete
involved_in	GO:0010991	negative regulation of SMAD protein complex assembly	PMID:16751101^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006499	N-terminal protein myristoylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49443	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:18930133^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49443	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16751101^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:11559703^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:20801214^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:10644691^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001418787 UniProtKB:P35813	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001418787 UniProtKB:P35813	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101841 MGI:MGI:99878 PANTHER:PTN002675662 UniProtKB:O15297 UniProtKB:O75688 UniProtKB:P35813	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99878 PANTHER:PTN002675662 UniProtKB:O15297 UniProtKB:O75688 UniProtKB:P35813	C		Seeded From UniProt	complete
enables	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000352745 PomBase:SPAC4A8.03c PomBase:SPCC4F11.02 RGD:620393 RGD:628812 SGD:S000000891	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086361 MGI:MGI:1919137 MGI:MGI:2139740 PANTHER:PTN000352745 PomBase:SPAC2G11.07c PomBase:SPAC4A8.03c PomBase:SPCC1223.11 PomBase:SPCC4F11.02 RGD:620128 RGD:620393 RGD:628812 RGD:631363 RGD:735028 SGD:S000000152 SGD:S000000329 SGD:S000000891 SGD:S000002133 SGD:S000002164 SGD:S000005616 TAIR:locus:2005488 TAIR:locus:2030230 TAIR:locus:2041444 TAIR:locus:2045678 TAIR:locus:2065046 TAIR:locus:2080787 TAIR:locus:2124784 TAIR:locus:2164610 TAIR:locus:2168449 UniProtKB:A0A1D8PRZ8 UniProtKB:O15297 UniProtKB:O15355 UniProtKB:O75688 UniProtKB:P35813 UniProtKB:P49593 UniProtKB:Q59MW1 UniProtKB:Q59PS6 UniProtKB:Q8IHY0 UniProtKB:Q8WY54 UniProtKB:Q9I757 UniProtKB:Q9P0J1 WB:WBGene00001412 dictyBase:DDB_G0276155	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	C		Seeded From UniProt	complete
involved_in	GO:0006499	N-terminal protein myristoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49443 ensembl:ENSMUSP00000021514	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012911 InterPro:IPR036580	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001932	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012911 InterPro:IPR036580	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015655	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015655	P		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012911 InterPro:IPR036580	F		Seeded From UniProt	complete
enables	GO:0043169	cation binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000222	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:1311954^[8] Reactome:R-HSA-380949 Reactome:R-HSA-209055	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	Reactome:R-HSA-380972	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-380949	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-2187388 Reactome:R-HSA-209055	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173795	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lin, X et al. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 125 915-28 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Sun, W et al. (2009) PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell. Signal. 21 95-102 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Tan, KM et al. (2001) The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. J. Biol. Chem. 276 44193-202 PubMed GONUTS page
↑ ^6.0 ^6.1 Voss, M et al. (2011) Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell. Signal. 23 114-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Mann, DJ et al. (1992) Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim. Biophys. Acta 1130 100-4 PubMed GONUTS page

[PMID:10644691-1] 1.0 ^1.1 ^1.2 ^1.3 Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page

[PMID:16751101-2] 2.0 ^2.1 ^2.2 ^2.3 Lin, X et al. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 125 915-28 PubMed GONUTS page

[PMID:18930133-3] 3.0 ^3.1 ^3.2 Sun, W et al. (2009) PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell. Signal. 21 95-102 PubMed GONUTS page

[PMID:12761501-4] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:11559703-5] 5.0 ^5.1 ^5.2 Tan, KM et al. (2001) The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. J. Biol. Chem. 276 44193-202 PubMed GONUTS page

[PMID:20801214-6] 6.0 ^6.1 Voss, M et al. (2011) Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell. Signal. 23 114-24 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1311954-8] Mann, DJ et al. (1992) Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim. Biophys. Acta 1130 100-4 PubMed GONUTS page

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HUMAN:PPM1A

Contents

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Notes

References

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