HUMAN:PPAP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACPP
Protein Name(s)	Prostatic acid phosphatase PAP 5'-nucleotidase 5'-NT Ecto-5'-nucleotidase Thiamine monophosphatase TMPase PAPf39
External Links
UniProt	P15309
EMBL	M97589 M97580 M97581 M97582 M97583 M97584 M97585 M97586 M97587 M97588 M34840 M24902 X52174 X53605 U07097 U07083 U07085 U07086 U07088 U07091 U07092 U07093 U07095 AB102888 AK300540 AC020633 CH471052 CH471052 BC007460 BC008493 BC016344
CCDS	CCDS3073.1 CCDS46916.1
PIR	JH0610
RefSeq	NP_001090.2 NP_001127666.1 NP_001278966.1
UniGene	Hs.433060
PDB	1CVI 1ND5 1ND6 2HPA 2L3H 2L77 2L79 3PPD
PDBsum	1CVI 1ND5 1ND6 2HPA 2L3H 2L77 2L79 3PPD
DisProt	DP00628
ProteinModelPortal	P15309
SMR	P15309
BioGrid	106571
IntAct	P15309
MINT	MINT-6780778
STRING	9606.ENSP00000323036
BindingDB	P15309
ChEMBL	CHEMBL2633
DEPOD	P15309
PhosphoSite	P15309
DMDM	130730
MaxQB	P15309
PaxDb	P15309
PRIDE	P15309
DNASU	55
Ensembl	ENST00000336375 ENST00000351273 ENST00000475741
GeneID	55
KEGG	hsa:55
UCSC	uc003eon.3 uc003eop.4 uc010htp.2
CTD	55
GeneCards	GC03P132036
HGNC	HGNC:125
HPA	CAB000071 HPA004335
MIM	171790
neXtProt	NX_P15309
PharmGKB	PA24449
eggNOG	NOG85977
GeneTree	ENSGT00530000062956
HOGENOM	HOG000231439
HOVERGEN	HBG002203
InParanoid	P15309
KO	K14410
OMA	FTLPSWA
OrthoDB	EOG7GXPBJ
PhylomeDB	P15309
TreeFam	TF312893
SABIO-RK	P15309
ChiTaRS	ACPP
EvolutionaryTrace	P15309
GeneWiki	Prostatic_acid_phosphatase
GenomeRNAi	55
NextBio	221
PMAP-CutDB	P15309
PRO	PR:P15309
Proteomes	UP000005640
Bgee	P15309
CleanEx	HS_ACPP
ExpressionAtlas	P15309
Genevestigator	P15309
GO	GO:0045177 GO:0005615 GO:0070062 GO:0030175 GO:0031985 GO:0016021 GO:0005622 GO:0005765 GO:0005771 GO:0005634 GO:0005886 GO:0030141 GO:0012506 GO:0008253 GO:0003993 GO:0033265 GO:0042802 GO:0052642 GO:0016791 GO:0042131 GO:0046085 GO:0016311 GO:0009117 GO:0060168 GO:0006144 GO:0051930 GO:0006772
Gene3D	3.40.50.1240
InterPro	IPR000560 IPR029033
Pfam	PF00328
SUPFAM	SSF53254
PROSITE	PS00616 PS00778

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005615	extracellular space	PMID:10639192^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001968)	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:10639192^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10639192^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0060168	positive regulation of adenosine receptor signaling pathway	PMID:18940592^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060168	positive regulation of adenosine receptor signaling pathway	PMID:22389722^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P30542)	Seeded From UniProt	complete
enables	GO:0052642	lysophosphatidic acid phosphatase activity	PMID:15280042^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:18940592^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0050965)	Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:22389722^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0050965)	Seeded From UniProt	complete
involved_in	GO:0046085	adenosine metabolic process	PMID:18940592^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042131	thiamine phosphate phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CE08	F		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:18940592^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:22389722^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	PMID:8132635^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CE08	C	part_of:(GO:0030426) part_of:(UBERON:0002240)\|part_of:(CL:1001451) part_of:(CL:0000198)	Seeded From UniProt	complete
enables	GO:0008253	5'-nucleotidase activity	PMID:18940592^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006772	thiamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CE08	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22389722^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0001968)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15280042^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)\|part_of:(UBERON:0001977)\|part_of:(UBERON:0006530)	Seeded From UniProt	complete
enables	GO:0003993	acid phosphatase activity	PMID:8132635^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17658863^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24657436^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15309	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18083097^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15309	F		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	P		Seeded From UniProt	complete
involved_in	GO:0046085	adenosine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	P		Seeded From UniProt	complete
enables	GO:0042131	thiamine phosphate phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	F		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	C		Seeded From UniProt	complete
involved_in	GO:0009117	nucleotide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	P		Seeded From UniProt	complete
involved_in	GO:0006772	thiamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	P		Seeded From UniProt	complete
involved_in	GO:0006144	purine nucleobase metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CE08 ensembl:ENSMUSP00000059889	C		Seeded From UniProt	complete
enables	GO:0008253	5'-nucleotidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.5	F		Seeded From UniProt	complete
enables	GO:0003993	acid phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.2	F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035577	azurophil granule membrane	Reactome:R-HSA-6798739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6798739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Jakob, CG et al. (2000) Crystal structure of human prostatic acid phosphatase . Prostate 42 211-8 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Zylka, MJ et al. (2008) Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron 60 111-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Hurt, JK et al. (2012) Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity. PLoS ONE 7 e32741 PubMed GONUTS page
↑ ^6.0 ^6.1 Tanaka, M et al. (2004) Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. FEBS Lett. 571 197-204 PubMed GONUTS page
↑ ^7.0 ^7.1 Ostanin, K et al. (1994) Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site. J. Biol. Chem. 269 8971-8 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Kang, S et al. (2007) Single-walled carbon nanotubes exhibit strong antimicrobial activity. Langmuir 23 8670-3 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ Tan, S et al. (2014) Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection. FEBS Lett. 588 1515-22 PubMed GONUTS page
↑ Münch, J et al. (2007) Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 131 1059-71 PubMed GONUTS page

[PMID:10639192-1] 1.0 ^1.1 ^1.2 Jakob, CG et al. (2000) Crystal structure of human prostatic acid phosphatase . Prostate 42 211-8 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:18940592-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Zylka, MJ et al. (2008) Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron 60 111-22 PubMed GONUTS page

[PMID:22389722-5] 5.0 ^5.1 ^5.2 ^5.3 Hurt, JK et al. (2012) Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity. PLoS ONE 7 e32741 PubMed GONUTS page

[PMID:15280042-6] 6.0 ^6.1 Tanaka, M et al. (2004) Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. FEBS Lett. 571 197-204 PubMed GONUTS page

[PMID:8132635-7] 7.0 ^7.1 Ostanin, K et al. (1994) Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site. J. Biol. Chem. 269 8971-8 PubMed GONUTS page

[PMID:21630459-8] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:17658863-9] Kang, S et al. (2007) Single-walled carbon nanotubes exhibit strong antimicrobial activity. Langmuir 23 8670-3 PubMed GONUTS page

[PMID:17897319-10] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:24657436-11] Tan, S et al. (2014) Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection. FEBS Lett. 588 1515-22 PubMed GONUTS page

[PMID:18083097-12] Münch, J et al. (2007) Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 131 1059-71 PubMed GONUTS page

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HUMAN:PPAP

Contents

Annotations

Notes

References

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