GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:PNCB
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NAPRT (synonyms: FHIP, NAPRT1) | |
| Protein Name(s) | Nicotinate phosphoribosyltransferase
NAPRTase FHA-HIT-interacting protein Nicotinate phosphoribosyltransferase domain-containing protein 1 | |
| External Links | ||
| UniProt | Q6XQN6 | |
| EMBL | AB242230 AY214325 AY214326 AY214327 BC006284 BC032466 | |
| CCDS | CCDS6403.2 CCDS69555.1 | |
| RefSeq | NP_001273758.1 NP_660202.3 | |
| UniGene | Hs.493164 | |
| PDB | 4YUB | |
| PDBsum | 4YUB | |
| ProteinModelPortal | Q6XQN6 | |
| SMR | Q6XQN6 | |
| BioGrid | 125001 | |
| IntAct | Q6XQN6 | |
| STRING | 9606.ENSP00000401508 | |
| iPTMnet | Q6XQN6 | |
| PhosphoSite | Q6XQN6 | |
| DMDM | 166221824 | |
| EPD | Q6XQN6 | |
| MaxQB | Q6XQN6 | |
| PaxDb | Q6XQN6 | |
| PRIDE | Q6XQN6 | |
| Ensembl | ENST00000426292 ENST00000449291 ENST00000621955 ENST00000632139 | |
| GeneID | 93100 | |
| KEGG | hsa:93100 | |
| UCSC | uc003yym.6 | |
| CTD | 93100 | |
| GeneCards | NAPRT | |
| HGNC | HGNC:30450 | |
| HPA | CAB068206 CAB068207 HPA023739 HPA024017 | |
| MIM | 611552 | |
| neXtProt | NX_Q6XQN6 | |
| PharmGKB | PA142671293 | |
| eggNOG | KOG2511 COG1488 | |
| GeneTree | ENSGT00390000002664 | |
| HOVERGEN | HBG062439 | |
| InParanoid | Q6XQN6 | |
| KO | K00763 | |
| OMA | DTWGVGT | |
| PhylomeDB | Q6XQN6 | |
| TreeFam | TF314732 | |
| BRENDA | 6.3.4.21 | |
| Reactome | R-HSA-197264 | |
| UniPathway | UPA00253 | |
| ChiTaRS | FAM160A2 | |
| GenomeRNAi | 93100 | |
| NextBio | 77980 | |
| PRO | PR:Q6XQN6 | |
| Proteomes | UP000005640 | |
| Bgee | Q6XQN6 | |
| CleanEx | HS_NAPRT1 | |
| ExpressionAtlas | Q6XQN6 | |
| Genevisible | Q6XQN6 | |
| GO | GO:0005737 GO:0005829 GO:0070062 GO:0005794 GO:0005634 GO:0016874 GO:0004516 GO:0004514 GO:0009435 GO:0019674 GO:0006769 GO:0019358 GO:0006979 GO:0044281 GO:0006766 GO:0006767 | |
| InterPro | IPR007229 IPR006405 IPR002638 | |
| PANTHER | PTHR11098 | |
| PIRSF | PIRSF000484 | |
| SUPFAM | SSF51690 | |
| TIGRFAMs | TIGR01513 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000314 |
F |
According to HHPRED the protein nicotinate phosphoribosyltransferase shares a homology with the protein Quinolinate Phosphoribosyl Transferase, with an e value of 1.2E-12. Figure 3 shows the structural homology between Dimer of scQAPRTase complexed with phthalate and PRPP. (B) Hexamer of aposcQAPRTase. The function of nicotinate phosphoribosyltransferase is to catalyze the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). |
complete | |||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034355 |
NAD salvage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000120696 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004514 |
nicotinate-nucleotide diphosphorylase (carboxylating) activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019358 |
nicotinate nucleotide salvage |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035578 |
azurophil granule lumen |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034356 |
NAD biosynthesis via nicotinamide riboside salvage pathway |
Reactome:R-HSA-197264 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-197186 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019363 |
pyridine nucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00253 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ di Luccio, E & Wilson, DK (2008) Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae. Biochemistry 47 4039-50 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hara, N et al. (2007) Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J. Biol. Chem. 282 24574-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
n
- GO:0034356 ! NAD biosynthesis via nicotinamide riboside salvage pathway
- GO:0009435 ! NAD biosynthetic process
- GO:0034355 ! NAD salvage
- GO:0043312 ! neutrophil degranulation
- GO:0004514 ! nicotinate-nucleotide diphosphorylase (carboxylating) activity
- GO:0019358 ! nicotinate nucleotide salvage
- GO:0004516 ! nicotinate phosphoribosyltransferase activity
