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HUMAN:PHLA3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PHLDA3 (synonyms: TIH1) | |
| Protein Name(s) | Pleckstrin homology-like domain family A member 3
TDAG51/Ipl homolog 1 | |
| External Links | ||
| UniProt | Q9Y5J5 | |
| EMBL | AF151100 AK075179 AK312115 AK222644 CH471067 BC014390 BC068273 | |
| CCDS | CCDS1412.1 | |
| RefSeq | NP_036528.1 | |
| UniGene | Hs.268557 | |
| ProteinModelPortal | Q9Y5J5 | |
| BioGrid | 117145 | |
| IntAct | Q9Y5J5 | |
| STRING | 9606.ENSP00000356278 | |
| PhosphoSite | Q9Y5J5 | |
| DMDM | 74735291 | |
| MaxQB | Q9Y5J5 | |
| PaxDb | Q9Y5J5 | |
| PRIDE | Q9Y5J5 | |
| DNASU | 23612 | |
| Ensembl | ENST00000367309 ENST00000367311 | |
| GeneID | 23612 | |
| KEGG | hsa:23612 | |
| UCSC | uc001gwq.4 | |
| CTD | 23612 | |
| GeneCards | GC01M201434 | |
| HGNC | HGNC:8934 | |
| HPA | HPA027601 | |
| MIM | 607054 | |
| neXtProt | NX_Q9Y5J5 | |
| PharmGKB | PA33275 | |
| eggNOG | NOG40478 | |
| GeneTree | ENSGT00440000039564 | |
| HOGENOM | HOG000115528 | |
| HOVERGEN | HBG052730 | |
| InParanoid | Q9Y5J5 | |
| OMA | VRARHSC | |
| OrthoDB | EOG7NKKM7 | |
| PhylomeDB | Q9Y5J5 | |
| TreeFam | TF332320 | |
| ChiTaRS | PHLDA3 | |
| GenomeRNAi | 23612 | |
| NextBio | 46318 | |
| PRO | PR:Q9Y5J5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y5J5 | |
| CleanEx | HS_PHLDA3 | |
| Genevestigator | Q9Y5J5 | |
| GO | GO:0005737 GO:0070062 GO:0005886 GO:0005547 GO:0043325 GO:0080025 GO:0032266 GO:0005546 GO:0010314 GO:0009653 GO:0042771 GO:0051898 GO:0043065 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR001849 IPR011993 | |
| SMART | SM00233 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0080025 |
phosphatidylinositol-3,5-bisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009653 |
anatomical structure morphogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0008285 |
negative regulation of cell proliferation |
ECO:0000315 |
P |
Figure 6 - PHLA3 knockout cells display more anchorage-independent cell proliferation. (GO does not have a more specific term for anchorage-dependent cell proliferation) |
complete | |||||
| GO:0005515 |
protein binding |
ECO:0000021 |
F |
complete | ||||||
| GO:0005515 |
protein binding |
ECO:0000021 |
F |
complete | ||||||
| GO:0005515 |
protein binding |
ECO:0000021 |
F |
complete | ||||||
| GO:0005515 |
protein binding |
ECO:0000021 |
F |
complete | ||||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Kawase, T et al. (2009) PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell 136 535-50 PubMed GONUTS page
- ↑ Frank, D et al. (1999) A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm. Genome 10 1150-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Ewing, RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 3 89 PubMed GONUTS page
i
n
p
- GO:0080025 ! phosphatidylinositol-3,5-bisphosphate binding
- GO:0005546 ! phosphatidylinositol-4,5-bisphosphate binding
- GO:0005547 ! phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0010314 ! phosphatidylinositol-5-phosphate binding
- GO:0032266 ! phosphatidylinositol-3-phosphate binding
- GO:0043325 ! phosphatidylinositol-3,4-bisphosphate binding
- GO:0005886 ! plasma membrane
- GO:0043065 ! positive regulation of apoptotic process
- Primates
- GO:0005515 ! protein binding
