HUMAN:PGS1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BGN (synonyms: SLRR1A)
Protein Name(s)	Biglycan Bone/cartilage proteoglycan I PG-S1
External Links
UniProt	P21810
EMBL	J04599 M65153 M65152 U82695 BT007323 CH471172 CH471172 BC002416 BC004244 U11686
CCDS	CCDS14721.1
PIR	A40757
RefSeq	NP_001702.1
UniGene	Hs.821
ProteinModelPortal	P21810
SMR	P21810
BioGrid	107102
IntAct	P21810
MINT	MINT-4529946
STRING	9606.ENSP00000327336
PhosphoSite	P21810
DMDM	266762
MaxQB	P21810
PaxDb	P21810
PRIDE	P21810
DNASU	633
Ensembl	ENST00000331595
GeneID	633
KEGG	hsa:633
UCSC	uc004fhr.2
CTD	633
GeneCards	GC0XP152762
HGNC	HGNC:1044
HPA	CAB003678 HPA003157
MIM	301870
neXtProt	NX_P21810
PharmGKB	PA25346
eggNOG	COG4886
GeneTree	ENSGT00760000118969
HOGENOM	HOG000261690
HOVERGEN	HBG016052
InParanoid	P21810
KO	K08118
OMA	QRGFWDF
PhylomeDB	P21810
TreeFam	TF334562
Reactome	REACT_120800 REACT_120888 REACT_120989 REACT_121408 REACT_163906 REACT_267642 REACT_267659 REACT_267682 REACT_267708 REACT_267711
ChiTaRS	BGN
GeneWiki	Biglycan
GenomeRNAi	633
NextBio	2558
PMAP-CutDB	P21810
PRO	PR:P21810
Proteomes	UP000005640
Bgee	P21810
CleanEx	HS_BGN
ExpressionAtlas	P21810
Genevestigator	P21810
GO	GO:0009986 GO:0005576 GO:0070062 GO:0005796 GO:0043202 GO:0005578 GO:0042383 GO:0030133 GO:0050840 GO:0005201 GO:0005539 GO:0001974 GO:0005975 GO:0030206 GO:0030207 GO:0030204 GO:0030208 GO:0030198 GO:0030203 GO:0019800 GO:0044281
InterPro	IPR028547 IPR001611 IPR000372 IPR016352
PANTHER	PTHR24369:SF6
Pfam	PF13855 PF01462
PIRSF	PIRSF002490
SMART	SM00013
PROSITE	PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:28327460^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)\|occurs_in:(CL:0002570)\|occurs_in:(CL:0002551)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9GKQ6	F	occurs_in:(UBERON:0002084)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:20551380^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:27559042^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0006618) occurs_in:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:28675934^[4]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)\|occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:25037231^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PMID:25037231^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:20551380^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9GKQ6	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
involved_in	GO:0008150	biological_process	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:1860845^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:1860845^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:2212616^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28653 ensembl:ENSMUSP00000033741	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28653 ensembl:ENSMUSP00000033741	C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28653 ensembl:ENSMUSP00000033741	C		Seeded From UniProt	complete
involved_in	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28653 ensembl:ENSMUSP00000033741	P		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28653 ensembl:ENSMUSP00000033741	F		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47853 ensembl:ENSRNOP00000072449	P		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	Reactome:R-HSA-2065233 Reactome:R-HSA-2022056 Reactome:R-HSA-1793176	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030208	dermatan sulfate biosynthetic process	Reactome:R-HSA-2022923	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030207	chondroitin sulfate catabolic process	Reactome:R-HSA-2024101	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030206	chondroitin sulfate biosynthetic process	Reactome:R-HSA-2022870	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-4420365 Reactome:R-HSA-3636919 Reactome:R-HSA-3595178 Reactome:R-HSA-3595176 Reactome:R-HSA-3595175 Reactome:R-HSA-3560804 Reactome:R-HSA-3560802 Reactome:R-HSA-2022911 Reactome:R-HSA-2022065 Reactome:R-HSA-2022063 Reactome:R-HSA-2022061 Reactome:R-HSA-2022052 Reactome:R-HSA-2018682 Reactome:R-HSA-2018659 Reactome:R-HSA-1971491 Reactome:R-HSA-1971487 Reactome:R-HSA-1971483 Reactome:R-HSA-1971482 Reactome:R-HSA-1889981 Reactome:R-HSA-1889978 Reactome:R-HSA-1889955 Reactome:R-HSA-1878002	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-2466133 Reactome:R-HSA-2466106 Reactome:R-HSA-2022911 Reactome:R-HSA-2022065 Reactome:R-HSA-2022056	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^2.0 ^2.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ ^10.0 ^10.1 Fisher, LW et al. (1991) Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. J. Biol. Chem. 266 14371-7 PubMed GONUTS page
↑ Bianco, P et al. (1990) Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J. Histochem. Cytochem. 38 1549-63 PubMed GONUTS page

[PMID:28327460-1] 1.0 ^1.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:20551380-2] 2.0 ^2.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:27559042-3] 3.0 ^3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:28675934-4] 4.0 ^4.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-5] 5.0 ^5.1 ^5.2 ^5.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-6] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23533145-7] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-8] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:22261194-9] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:1860845-10] 10.0 ^10.1 Fisher, LW et al. (1991) Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. J. Biol. Chem. 266 14371-7 PubMed GONUTS page

[PMID:2212616-11] Bianco, P et al. (1990) Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J. Histochem. Cytochem. 38 1549-63 PubMed GONUTS page

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HUMAN:PGS1

Contents

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References

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