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HUMAN:PGRP2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PGLYRP2 (synonyms: PGLYRPL, PGRPL)
Protein Name(s) N-acetylmuramoyl-L-alanine amidase

Peptidoglycan recognition protein 2 Peptidoglycan recognition protein long PGRP-L

External Links
UniProt Q96PD5
EMBL AF384856
AB073610
AY358156
AK055882
AK289415
AK292292
CH471106
CH471106
BC136551
BC136552
BC144238
CCDS CCDS12330.2
RefSeq NP_443122.3
XP_006722696.1
UniGene Hs.282244
ProteinModelPortal Q96PD5
SMR Q96PD5
IntAct Q96PD5
STRING 9606.ENSP00000345968
iPTMnet Q96PD5
BioMuta PGLYRP2
DMDM 38258222
PaxDb Q96PD5
PeptideAtlas Q96PD5
PRIDE Q96PD5
Ensembl ENST00000292609
ENST00000340880
GeneID 114770
KEGG hsa:114770
UCSC uc002nbf.5
CTD 114770
GeneCards PGLYRP2
HGNC HGNC:30013
HPA CAB033468
HPA043568
HPA046311
MIM 608199
neXtProt NX_Q96PD5
PharmGKB PA134929965
eggNOG ENOG410IIH1
ENOG4111PAY
GeneTree ENSGT00390000016833
HOGENOM HOG000276878
HOVERGEN HBG053578
InParanoid Q96PD5
KO K01446
OMA TEAFLGC
OrthoDB EOG757CZ5
PhylomeDB Q96PD5
TreeFam TF323898
BRENDA 3.5.1.28
GeneWiki PGLYRP2
GenomeRNAi 114770
PRO PR:Q96PD5
Proteomes UP000005640
Bgee Q96PD5
CleanEx HS_PGLYRP2
ExpressionAtlas Q96PD5
Genevisible Q96PD5
GO GO:0070062
GO:0005622
GO:0016020
GO:0008745
GO:0042834
GO:0016019
GO:0008270
GO:0050830
GO:0016045
GO:0044117
GO:0045087
GO:0032689
GO:0032827
GO:0002221
GO:0001519
GO:0009253
GO:0050727
Gene3D 3.40.80.10
InterPro IPR002502
IPR015510
IPR006619
PANTHER PTHR11022
Pfam PF01510
SMART SM00644
SM00701
SUPFAM SSF55846

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:14506276[1]

ECO:0000314

F

Fig. 2. PGRP-L is an N-acetylmuramoyl-l-alanine amidase that digests polymeric PGN and synthetic MurNAc-tripeptide.

complete
CACAO 12147

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:14506276[1]

ECO:0000247

UniProtKB:D1LVD8


F

Figure 3 shows that the amino acid sequence of PGRP2 shared some homologies with the bacteriophage T7 lysozyme, which is a member of a family of bacteriophage and bacterial type 2 N-acetylmuramoyl-L-alanine amidases.

complete
CACAO 12174

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:11461926[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:11461926[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:11461926[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

PMID:11461926[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11461926[3]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016019

peptidoglycan receptor activity

PMID:11461926[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001519

peptide amidation

PMID:7663175[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030310
FB:FBgn0030695
FB:FBgn0035806
FB:FBgn0037906
PANTHER:PTN001336553
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030310
FB:FBgn0033327
FB:FBgn0035806
FB:FBgn0035976
FB:FBgn0035977
PANTHER:PTN001664863
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

F

Seeded From UniProt

complete

involved_in

GO:0032827

negative regulation of natural killer cell differentiation involved in immune response

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345092
MGI:MGI:1928099
MGI:MGI:2685266
MGI:MGI:2686324
PANTHER:PTN001336553

P

Seeded From UniProt

complete

involved_in

GO:0019730

antimicrobial humoral response

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035976
PANTHER:PTN001336553

P

Seeded From UniProt

complete

enables

GO:0016019

peptidoglycan receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035976
PANTHER:PTN001664864
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033327
FB:FBgn0037906
FB:FBgn0043578
PANTHER:PTN001664864
UniProtKB:Q96PD5
ZFIN:ZDB-GENE-050419-71
ZFIN:ZDB-GENE-071227-2

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035806
PANTHER:PTN001664863

C

Seeded From UniProt

complete

involved_in

GO:0002221

pattern recognition receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016019

P

Seeded From UniProt

complete

involved_in

GO:0002221

pattern recognition receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016019

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006619

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR036505

F

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR036505

P

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.28

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:7663175[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6799981
Reactome:R-HSA-6799977

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Wang, ZM et al. (2003) Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. J. Biol. Chem. 278 49044-52 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Liu, C et al. (2001) Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. J. Biol. Chem. 276 34686-94 PubMed GONUTS page
  4. ↑ 4.0 4.1 De Pauw, P et al. (1995) Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography. Protein Expr. Purif. 6 371-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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