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HUMAN:PGRC1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PGRMC1 (synonyms: HPR6.6, PGRMC) | |
| Protein Name(s) | Membrane-associated progesterone receptor component 1
mPR | |
| External Links | ||
| UniProt | O00264 | |
| EMBL | Y12711 AK293618 AC004835 CH471161 BC034238 AJ249131 | |
| CCDS | CCDS14576.1 CCDS65313.1 | |
| RefSeq | NP_001269550.1 NP_006658.1 | |
| UniGene | Hs.90061 | |
| ProteinModelPortal | O00264 | |
| SMR | O00264 | |
| BioGrid | 116068 | |
| IntAct | O00264 | |
| MINT | MINT-2997519 | |
| STRING | 9606.ENSP00000217971 | |
| DrugBank | DB00514 DB00540 | |
| PhosphoSite | O00264 | |
| OGP | O00264 | |
| MaxQB | O00264 | |
| PaxDb | O00264 | |
| PeptideAtlas | O00264 | |
| PRIDE | O00264 | |
| DNASU | 10857 | |
| Ensembl | ENST00000217971 ENST00000535419 | |
| GeneID | 10857 | |
| KEGG | hsa:10857 | |
| UCSC | uc004erb.3 uc011mts.2 | |
| CTD | 10857 | |
| GeneCards | GC0XP118370 | |
| HGNC | HGNC:16090 | |
| HPA | HPA002877 | |
| MIM | 300435 | |
| neXtProt | NX_O00264 | |
| PharmGKB | PA33248 | |
| eggNOG | NOG291734 | |
| GeneTree | ENSGT00730000110959 | |
| HOGENOM | HOG000187840 | |
| HOVERGEN | HBG059971 | |
| InParanoid | O00264 | |
| KO | K17278 | |
| OMA | EHDDLSD | |
| OrthoDB | EOG7KWSKJ | |
| PhylomeDB | O00264 | |
| TreeFam | TF314562 | |
| ChiTaRS | PGRMC1 | |
| GeneWiki | PGRMC1 | |
| GenomeRNAi | 10857 | |
| NextBio | 35478759 | |
| PRO | PR:O00264 | |
| Proteomes | UP000005640 | |
| Bgee | O00264 | |
| CleanEx | HS_PGRMC1 | |
| ExpressionAtlas | O00264 | |
| Genevestigator | O00264 | |
| GO | GO:0005783 GO:0005789 GO:0070062 GO:0016021 GO:0016020 GO:0005730 GO:0020037 GO:0005496 GO:0007411 | |
| Gene3D | 3.10.120.10 | |
| InterPro | IPR001199 | |
| Pfam | PF00173 | |
| SUPFAM | SSF55856 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0045202 |
synapse |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044297 |
cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(CL:0000125) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001540 |
amyloid-beta binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005496 |
steroid binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035579 |
specific granule membrane |
Reactome:R-HSA-6799350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6799350 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005496 |
steroid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030868 |
smooth endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031090 |
organelle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ De Strooper, B & Karran, E (2016) The Cellular Phase of Alzheimer's Disease. Cell 164 603-15 PubMed GONUTS page
- ↑ 3.0 3.1 Izzo, NJ et al. (2014) Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS ONE 9 e111899 PubMed GONUTS page
- ↑ Gerdes, D et al. (1998) Cloning and tissue expression of two putative steroid membrane receptors. Biol. Chem. 379 907-11 PubMed GONUTS page
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