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PMID:9705155

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Citation

Gerdes, D, Wehling, M, Leube, B and Falkenstein, E (1998) Cloning and tissue expression of two putative steroid membrane receptors. Biol. Chem. 379:907-11

Abstract

We have cloned two human putative steroid binding membrane proteins, termed Hpr6.6 and Dg6. Hpr6.6 is the human homolog of a previously cloned porcine progesterone binding protein. Both proteins contain a putative transmembrane domain and a highly conserved stretch of 58 amino acids. Hpr6.6 mRNA is expressed predominantly in liver and kidney, whereas Dg6 mRNA is preferentially expressed in placenta. Hpr6.6 is located on the X chromosome and dg6 on chromosome 4. The two proteins are the first putative steroid membrane receptors cloned from man.

Links

PubMed

Keywords

Amino Acid Sequence; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Molecular Sequence Data; Receptors, Progesterone; Receptors, Steroid/biosynthesis; Receptors, Steroid/genetics; Tissue Distribution

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PGRC2

enables

GO:0005496: steroid binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:PGRC2

located_in

GO:0016021: integral component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:PGRC2

enables

GO:0003707: steroid hormone receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:PGRC1

enables

GO:0005496: steroid binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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