HUMAN:PERM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MPO
Protein Name(s)	Myeloperoxidase MPO Myeloperoxidase 89 kDa myeloperoxidase 84 kDa myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain
External Links
UniProt	P05164
EMBL	J02694 M17176 M17170 M17171 M17172 M17173 M17174 M17175 X04876 M19507 M19508 M19508 X15377 S56200 DQ088846 CH471109 BC130476 D14466
CCDS	CCDS11604.1
PIR	A29467 B28894 D28894
RefSeq	NP_000241.1
UniGene	Hs.458272
PDB	1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX
PDBsum	1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX
ProteinModelPortal	P05164
SMR	P05164
BioGrid	110493
IntAct	P05164
MINT	MINT-1522833
STRING	9606.ENSP00000225275
BindingDB	P05164
ChEMBL	CHEMBL2439
DrugBank	DB00233 DB00006 DB02300 DB00958 DB00833 DB00535 DB00515 DB00847 DB00250 DB01225 DB00062 DB00583 DB01065 DB00244 DB00461 DB00104 DB00526 DB00550 DB00208 DB00500
GuidetoPHARMACOLOGY	2789
PeroxiBase	3315
PhosphoSite	P05164
UniCarbKB	P05164
DMDM	129825
PaxDb	P05164
PRIDE	P05164
DNASU	4353
Ensembl	ENST00000225275
GeneID	4353
KEGG	hsa:4353
UCSC	uc002ivu.1
CTD	4353
GeneCards	GC17M056347
H-InvDB	HIX0039242
HGNC	HGNC:7218
HPA	CAB000059 HPA021147
MIM	254600 606989
neXtProt	NX_P05164
Orphanet	2587
PharmGKB	PA243
eggNOG	NOG262194
GeneTree	ENSGT00550000074325
HOGENOM	HOG000016084
HOVERGEN	HBG000071
InParanoid	P05164
KO	K10789
OMA	KSSGCAY
OrthoDB	EOG7M0NQW
PhylomeDB	P05164
TreeFam	TF314316
BioCyc	MetaCyc:HS00140-MONOMER
ChiTaRS	MPO
EvolutionaryTrace	P05164
GeneWiki	Myeloperoxidase
GenomeRNAi	4353
NextBio	17126
PMAP-CutDB	P05164
PRO	PR:P05164
Proteomes	UP000005640
Bgee	P05164
CleanEx	HS_MPO
ExpressionAtlas	P05164
Genevestigator	P05164
GO	GO:0042582 GO:0005615 GO:0070062 GO:0005764 GO:0005739 GO:0005634 GO:0030141 GO:0003682 GO:0020037 GO:0008201 GO:0046872 GO:0004601 GO:0007568 GO:0006952 GO:0050832 GO:0042744 GO:0002149 GO:0034374 GO:0043066 GO:0044130 GO:0055114 GO:0019430 GO:0002679 GO:0032094 GO:1990268 GO:0032496 GO:0009612 GO:0006979 GO:0001878
Gene3D	1.10.640.10
InterPro	IPR010255 IPR019791 IPR029609
PANTHER	PTHR11475:SF46
Pfam	PF03098
PRINTS	PR00457
SUPFAM	SSF48113
PROSITE	PS00435 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004601	peroxidase activity	PMID:24035742^[1]	ECO:0000314			F		Fig. 1. shows loss of peroxidatic activity of myeloperoxidase upon incubation with hydrogen peroxide	complete CACAO 8699
part_of	GO:0005615	extracellular space	PMID:25645918^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0007311)	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:24035742^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:10772654^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:10772654^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034374	low-density lipoprotein particle remodeling	PMID:10772654^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10772654^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:10772654^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0042582	azurophil granule	PMID:2981589^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000158767 UniProtKB:P22079	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1923363 PANTHER:PTN000158767	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000895746 RGD:1592081 UniProtKB:P05164 UniProtKB:P22079 UniProtKB:P80025 UniProtKB:Q92626	C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107569 MGI:MGI:1923363 MGI:MGI:97137 PANTHER:PTN000158755 RGD:1592081 UniProtKB:P05164 UniProtKB:Q92626 WB:WBGene00009897 WB:WBGene00022743	F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:11907569^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:11907569^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11907569^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:11907569^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	F		Seeded From UniProt	complete
involved_in	GO:0002679	respiratory burst involved in defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:0002149	hypochlorous acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11247 ensembl:ENSMUSP00000020779	P		Seeded From UniProt	complete
involved_in	GO:1990268	response to gold nanoparticle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1A2 ensembl:ENSRNOP00000071759	F		Seeded From UniProt	complete
involved_in	GO:0002149	hypochlorous acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029609	P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255 InterPro:IPR029609	F		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029609	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10801811^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:2829220^[12] PMID:2903767^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:8621627^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:8621627^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2829220^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:10777476^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:2829220^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0097013	phagocytic vesicle lumen	Reactome:R-HSA-8933635 Reactome:R-HSA-6789136 Reactome:R-HSA-6789126 Reactome:R-HSA-6789031	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	Reactome:R-HSA-1222556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0376	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Paumann-Page, M et al. (2013) Inactivation of human myeloperoxidase by hydrogen peroxide. Arch. Biochem. Biophys. 539 51-62 PubMed GONUTS page
↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Podrez, EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. Clin. Invest. 105 1095-108 PubMed GONUTS page
↑ Cramer, E et al. (1985) Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold. Blood 65 423-32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page
↑ Wagner, BA et al. (2000) Myeloperoxidase is involved in H2O2-induced apoptosis of HL-60 human leukemia cells. J. Biol. Chem. 275 22461-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Murao, S et al. (1988) Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties. Proc. Natl. Acad. Sci. U.S.A. 85 1232-6 PubMed GONUTS page
↑ Hashinaka, K et al. (1988) Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation. Biochemistry 27 5906-14 PubMed GONUTS page
↑ ^14.0 ^14.1 Nauseef, WM et al. (1996) Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. J. Biol. Chem. 271 9546-9 PubMed GONUTS page
↑ Burner, U et al. (2000) Mechanism of reaction of myeloperoxidase with nitrite. J. Biol. Chem. 275 20597-601 PubMed GONUTS page

[PMID:24035742-1] 1.0 ^1.1 Paumann-Page, M et al. (2013) Inactivation of human myeloperoxidase by hydrogen peroxide. Arch. Biochem. Biophys. 539 51-62 PubMed GONUTS page

[PMID:25645918-2] Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:21630459-5] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16502470-6] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:10772654-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Podrez, EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. Clin. Invest. 105 1095-108 PubMed GONUTS page

[PMID:2981589-8] Cramer, E et al. (1985) Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold. Blood 65 423-32 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11907569-10] 10.0 ^10.1 ^10.2 ^10.3 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page

[PMID:10801811-11] Wagner, BA et al. (2000) Myeloperoxidase is involved in H2O2-induced apoptosis of HL-60 human leukemia cells. J. Biol. Chem. 275 22461-9 PubMed GONUTS page

[PMID:2829220-12] 12.0 ^12.1 ^12.2 Murao, S et al. (1988) Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties. Proc. Natl. Acad. Sci. U.S.A. 85 1232-6 PubMed GONUTS page

[PMID:2903767-13] Hashinaka, K et al. (1988) Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation. Biochemistry 27 5906-14 PubMed GONUTS page

[PMID:8621627-14] 14.0 ^14.1 Nauseef, WM et al. (1996) Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. J. Biol. Chem. 271 9546-9 PubMed GONUTS page

[PMID:10777476-15] Burner, U et al. (2000) Mechanism of reaction of myeloperoxidase with nitrite. J. Biol. Chem. 275 20597-601 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

HUMAN:PERM

Contents

Annotations

Notes

References

a

c

d

e

h

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools