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HUMAN:PEPL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PPL (synonyms: KIAA0568)
Protein Name(s) Periplakin

190 kDa paraneoplastic pemphigus antigen 195 kDa cornified envelope precursor protein

External Links
UniProt O60437
EMBL AF001691
AF013717
AF041004
AF040999
AF041000
AF041002
AF041003
AC027687
CH471112
BC114620
AB011140
CCDS CCDS10526.1
PIR T00337
RefSeq NP_002696.3
UniGene Hs.192233
PDB 4Q28
PDBsum 4Q28
ProteinModelPortal O60437
SMR O60437
BioGrid 111488
IntAct O60437
MINT MINT-1181651
STRING 9606.ENSP00000340510
PhosphoSite O60437
MaxQB O60437
PaxDb O60437
PRIDE O60437
Ensembl ENST00000345988
GeneID 5493
KEGG hsa:5493
UCSC uc002cyd.1
CTD 5493
GeneCards GC16M004932
H-InvDB HIX0012794
HGNC HGNC:9273
HPA HPA042550
MIM 602871
neXtProt NX_O60437
PharmGKB PA33602
eggNOG NOG280386
GeneTree ENSGT00760000119163
HOGENOM HOG000168302
HOVERGEN HBG053564
InParanoid O60437
KO K10386
OMA LPLVDHQ
OrthoDB EOG7XM2WT
PhylomeDB O60437
TreeFam TF342779
GeneWiki Periplakin
GenomeRNAi 5493
NextBio 21238
PRO PR:O60437
Proteomes UP000005640
Bgee O60437
CleanEx HS_PPL
ExpressionAtlas O60437
Genevestigator O60437
GO GO:0005856
GO:0030057
GO:0070062
GO:0005739
GO:0005634
GO:0005886
GO:0005200
GO:0031424
InterPro IPR001101
IPR018159
Pfam PF00681
SMART SM00250
SM00150
SUPFAM SSF75399

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0045296

cadherin binding

PMID:25468996[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

PMID:19211270[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

  • occurs_in:(CL:0000359)
  • occurs_in:(UBERON:0000947)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0045104

intermediate filament cytoskeleton organization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109611
PANTHER:PTN002753757
UniProtKB:Q03001

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108559
PANTHER:PTN002753757
RGD:1305794
UniProtKB:P58107

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104627
PANTHER:PTN002753757
RGD:1306057

C

Seeded From UniProt

complete

colocalizes_with

GO:0005882

intermediate filament

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109611
PANTHER:PTN002753757
WB:WBGene00006876

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104627
MGI:MGI:108559
MGI:MGI:2386306
PANTHER:PTN002753757
UniProtKB:Q03001
UniProtKB:Q9UPN3

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002753757
UniProtKB:P15924
UniProtKB:Q92817

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001101

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:9521878[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:9521878[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

Reactome:R-HSA-6809371

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8938431
Reactome:R-HSA-6814764
Reactome:R-HSA-6814734
Reactome:R-HSA-6814387
Reactome:R-HSA-6814374
Reactome:R-HSA-6814298
Reactome:R-HSA-6814187
Reactome:R-HSA-6811539
Reactome:R-HSA-6810937
Reactome:R-HSA-6810894
Reactome:R-HSA-6810843

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

part_of

GO:0001533

cornified envelope

Reactome:R-HSA-6814764

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0417

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

part_of

GO:0030057

desmosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0092

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  2. Pyle, AL et al. () Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. Cardiovasc. Pathol. 19 e13-20 PubMed GONUTS page
  3. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 Aho, S et al. (1998) cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes. Genomics 48 242-7 PubMed GONUTS page