GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:PCM1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PCM1 | |
Protein Name(s) | Pericentriolar material 1 protein
PCM-1 hPCM-1 | |
External Links | ||
UniProt | Q15154 | |
EMBL | L27841 AC087273 AC087625 BC000453 BC027477 BC065022 AK091406 AJ297349 | |
CCDS | CCDS47812.1 | |
PIR | A54103 | |
RefSeq | NP_006188.3 | |
UniGene | Hs.491148 | |
ProteinModelPortal | Q15154 | |
BioGrid | 111139 | |
DIP | DIP-42189N | |
IntAct | Q15154 | |
MINT | MINT-3295236 | |
STRING | 9606.ENSP00000327077 | |
PhosphoSite | Q15154 | |
DMDM | 296439495 | |
MaxQB | Q15154 | |
PaxDb | Q15154 | |
PRIDE | Q15154 | |
DNASU | 5108 | |
Ensembl | ENST00000325083 | |
GeneID | 5108 | |
KEGG | hsa:5108 | |
UCSC | uc003wyi.4 | |
CTD | 5108 | |
GeneCards | GC08P017781 | |
H-InvDB | HIX0007341 | |
HGNC | HGNC:8727 | |
HPA | CAB058695 HPA023370 HPA023374 | |
MIM | 188550 600299 | |
neXtProt | NX_Q15154 | |
Orphanet | 146 | |
PharmGKB | PA33073 | |
eggNOG | NOG43239 | |
HOGENOM | HOG000115473 | |
HOVERGEN | HBG053890 | |
InParanoid | Q15154 | |
KO | K16537 | |
OrthoDB | EOG7VTDM3 | |
PhylomeDB | Q15154 | |
TreeFam | TF328740 | |
Reactome | REACT_15296 REACT_15364 REACT_15451 REACT_160315 | |
ChiTaRS | PCM1 | |
GeneWiki | PCM1 | |
GenomeRNAi | 5108 | |
NextBio | 19712 | |
PRO | PR:Q15154 | |
Proteomes | UP000005640 | |
Bgee | Q15154 | |
CleanEx | HS_PCM1 | |
ExpressionAtlas | Q15154 | |
Genevestigator | Q15154 | |
GO | GO:0034451 GO:0005813 GO:0036064 GO:0005737 GO:0005829 GO:0016020 GO:0031965 GO:0000242 GO:0043234 GO:0042802 GO:0051297 GO:0042384 GO:0031122 GO:0000086 GO:0022027 GO:0035735 GO:0034453 GO:0034454 GO:0000278 GO:0050768 GO:0097150 GO:0090316 GO:0071539 | |
InterPro | IPR024138 | |
PANTHER | PTHR14164 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0005813 |
centrosome |
ECO:0000314 |
C |
Fig.8A |
complete | |||||
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002586) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002586) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0031122 |
cytoplasmic microtubule organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1905515 |
non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(CL:0002586) |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007098 |
centrosome cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050768 |
negative regulation of neurogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034453 |
microtubule anchoring |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
NOT|part_of |
GO:0097730 |
non-motile cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0022027 |
interkinetic nuclear migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000242 |
pericentriolar material |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090316 |
positive regulation of intracellular protein transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090316 |
positive regulation of intracellular protein transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031122 |
cytoplasmic microtubule organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001423461 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001423461 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034454 |
microtubule anchoring at centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007098 |
centrosome cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001423461 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005814 |
centriole |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277958 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097150 |
neuronal stem cell population maintenance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050768 |
negative regulation of neurogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045177 |
apical part of cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035176 |
social behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034454 |
microtubule anchoring at centrosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034453 |
microtubule anchoring |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033365 |
protein localization to organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022027 |
interkinetic nuclear migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005814 |
centriole |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001764 |
neuron migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0000242 |
pericentriolar material |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R0L6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034454 |
microtubule anchoring at centrosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000242 |
pericentriolar material |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-380283 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
Reactome:R-HSA-69275 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097711 |
ciliary basal body-plasma membrane docking |
Reactome:R-HSA-5620912 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
Reactome:R-HSA-8854518 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
- ↑ Hall, EA et al. (2013) Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet. 9 e1003928 PubMed GONUTS page
- ↑ 3.0 3.1 Kodani, A et al. (2010) Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol. Biol. Cell 21 3376-85 PubMed GONUTS page
- ↑ Greer, YE et al. (2014) Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Mol. Biol. Cell 25 1629-40 PubMed GONUTS page
- ↑ 5.0 5.1 Staples, CJ et al. (2014) Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J. Cell. Sci. 127 2910-9 PubMed GONUTS page
- ↑ Sillibourne, JE et al. (2013) Primary ciliogenesis requires the distal appendage component Cep123. Biol Open 2 535-45 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Nachury, MV et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129 1201-13 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Staples, CJ et al. (2012) The centriolar satellite protein Cep131 is important for genome stability. J. Cell. Sci. 125 4770-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Chamling, X et al. (2014) The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 10 e1004083 PubMed GONUTS page
- ↑ 11.0 11.1 Martin, J et al. (2004) The sequence and analysis of duplication-rich human chromosome 16. Nature 432 988-94 PubMed GONUTS page
- ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 14.0 14.1 Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Balczon, R et al. (1994) PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. J. Cell Biol. 124 783-93 PubMed GONUTS page
c
- Catarrhini
- GO:0042995 ! cell projection
- GO:0030030 ! cell projection organization
- GO:0034451 ! centriolar satellite
- GO:0005814 ! centriole
- GO:0005813 ! centrosome
- GO:0007098 ! centrosome cycle
- Chordata
- GO:0036064 ! ciliary basal body
- GO:0097711 ! ciliary basal body-plasma membrane docking
- GO:0035869 ! ciliary transition zone
- GO:0060271 ! cilium assembly
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031122 ! cytoplasmic microtubule organization
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
i
m
n
p