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HUMAN:PCM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PCM1
Protein Name(s) Pericentriolar material 1 protein

PCM-1 hPCM-1

External Links
UniProt Q15154
EMBL L27841
AC087273
AC087625
BC000453
BC027477
BC065022
AK091406
AJ297349
CCDS CCDS47812.1
PIR A54103
RefSeq NP_006188.3
UniGene Hs.491148
ProteinModelPortal Q15154
BioGrid 111139
DIP DIP-42189N
IntAct Q15154
MINT MINT-3295236
STRING 9606.ENSP00000327077
PhosphoSite Q15154
DMDM 296439495
MaxQB Q15154
PaxDb Q15154
PRIDE Q15154
DNASU 5108
Ensembl ENST00000325083
GeneID 5108
KEGG hsa:5108
UCSC uc003wyi.4
CTD 5108
GeneCards GC08P017781
H-InvDB HIX0007341
HGNC HGNC:8727
HPA CAB058695
HPA023370
HPA023374
MIM 188550
600299
neXtProt NX_Q15154
Orphanet 146
PharmGKB PA33073
eggNOG NOG43239
HOGENOM HOG000115473
HOVERGEN HBG053890
InParanoid Q15154
KO K16537
OrthoDB EOG7VTDM3
PhylomeDB Q15154
TreeFam TF328740
Reactome REACT_15296
REACT_15364
REACT_15451
REACT_160315
ChiTaRS PCM1
GeneWiki PCM1
GenomeRNAi 5108
NextBio 19712
PRO PR:Q15154
Proteomes UP000005640
Bgee Q15154
CleanEx HS_PCM1
ExpressionAtlas Q15154
Genevestigator Q15154
GO GO:0034451
GO:0005813
GO:0036064
GO:0005737
GO:0005829
GO:0016020
GO:0031965
GO:0000242
GO:0043234
GO:0042802
GO:0051297
GO:0042384
GO:0031122
GO:0000086
GO:0022027
GO:0035735
GO:0034453
GO:0034454
GO:0000278
GO:0050768
GO:0097150
GO:0090316
GO:0071539
InterPro IPR024138
PANTHER PTHR14164

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005813

centrosome

PMID:17139249[1]

ECO:0000314

C

Fig.8A

complete

part_of

GO:0035869

ciliary transition zone

PMID:24415959[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:20719959[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

PMID:20719959[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005813

centrosome

PMID:24648492[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

PMID:24816561[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031122

cytoplasmic microtubule organization

PMID:24816561[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1905515

non-motile cilium assembly

PMID:23789104[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(CL:0002586)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

P

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:17574030[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050768

negative regulation of neurogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9PVV4

F

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:17574030[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

P

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

PMID:17574030[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|part_of

GO:0097730

non-motile cilium

PMID:17574030[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0022027

interkinetic nuclear migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

C

Seeded From UniProt

complete

part_of

GO:0000242

pericentriolar material

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R0L6

C

Seeded From UniProt

complete

involved_in

GO:0090316

positive regulation of intracellular protein transport

PMID:22797915[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090316

positive regulation of intracellular protein transport

PMID:24550735[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:15616553[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

PMID:24550735[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

PMID:24550735[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

PMID:15616553[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031122

cytoplasmic microtubule organization

PMID:22797915[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:22797915[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:24550735[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461
RGD:620901
UniProtKB:Q15154

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001423461
UniProtKB:Q15154

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461

C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001423461
UniProtKB:Q15154

P

Seeded From UniProt

complete

involved_in

GO:0034454

microtubule anchoring at centrosome

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461

P

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461
UniProtKB:Q15154

C

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001423461
UniProtKB:Q15154

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277958
PANTHER:PTN001423461
UniProtKB:Q15154

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:24421332[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:24421332[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097150

neuronal stem cell population maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

involved_in

GO:0050768

negative regulation of neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

part_of

GO:0045177

apical part of cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

involved_in

GO:0034454

microtubule anchoring at centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

involved_in

GO:0033365

protein localization to organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

involved_in

GO:0022027

interkinetic nuclear migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

P

Seeded From UniProt

complete

part_of

GO:0000242

pericentriolar material

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0L6
ensembl:ENSMUSP00000039709

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024138

C

Seeded From UniProt

complete

involved_in

GO:0034454

microtubule anchoring at centrosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024138

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024138

P

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024138

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:8120099[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8120099[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000242

pericentriolar material

PMID:8120099[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-380283
Reactome:R-HSA-380272
Reactome:R-HSA-3000319
Reactome:R-HSA-3000310
Reactome:R-HSA-2574845
Reactome:R-HSA-2574840
Reactome:R-HSA-8853419
Reactome:R-HSA-8853405
Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5626223
Reactome:R-HSA-5626220
Reactome:R-HSA-5617816
Reactome:R-HSA-380508
Reactome:R-HSA-380455
Reactome:R-HSA-380316
Reactome:R-HSA-380311
Reactome:R-HSA-380303
Reactome:R-HSA-380294

ECO:0000304

author statement supported by traceable reference used in manual assertion






















C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
  2. Hall, EA et al. (2013) Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet. 9 e1003928 PubMed GONUTS page
  3. 3.0 3.1 Kodani, A et al. (2010) Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol. Biol. Cell 21 3376-85 PubMed GONUTS page
  4. Greer, YE et al. (2014) Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Mol. Biol. Cell 25 1629-40 PubMed GONUTS page
  5. 5.0 5.1 Staples, CJ et al. (2014) Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J. Cell. Sci. 127 2910-9 PubMed GONUTS page
  6. Sillibourne, JE et al. (2013) Primary ciliogenesis requires the distal appendage component Cep123. Biol Open 2 535-45 PubMed GONUTS page
  7. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Nachury, MV et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129 1201-13 PubMed GONUTS page
  9. 9.0 9.1 9.2 Staples, CJ et al. (2012) The centriolar satellite protein Cep131 is important for genome stability. J. Cell. Sci. 125 4770-9 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Chamling, X et al. (2014) The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 10 e1004083 PubMed GONUTS page
  11. 11.0 11.1 Martin, J et al. (2004) The sequence and analysis of duplication-rich human chromosome 16. Nature 432 988-94 PubMed GONUTS page
  12. Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  14. 14.0 14.1 Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page
  15. 15.0 15.1 15.2 Balczon, R et al. (1994) PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. J. Cell Biol. 124 783-93 PubMed GONUTS page