GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:PARG
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PARG | |
| Protein Name(s) | Poly(ADP-ribose) glycohydrolase | |
| External Links | ||
| UniProt | Q86W56 | |
| EMBL | AY258587 AY575848 AY575849 AF005043 EF382674 JQ890226 AK295786 AK302560 AK314909 BC050560 BC052966 | |
| CCDS | CCDS73130.1 | |
| RefSeq | NP_003622.2 | |
| UniGene | Hs.10136 Hs.535298 Hs.732225 | |
| PDB | 4A0D 4B1G 4B1H 4B1I 4B1J | |
| PDBsum | 4A0D 4B1G 4B1H 4B1I 4B1J | |
| ProteinModelPortal | Q86W56 | |
| SMR | Q86W56 | |
| BioGrid | 114077 | |
| IntAct | Q86W56 | |
| STRING | 9606.ENSP00000384408 | |
| BindingDB | Q86W56 | |
| ChEMBL | CHEMBL1795143 | |
| PhosphoSite | Q86W56 | |
| DMDM | 56417893 | |
| MaxQB | Q86W56 | |
| PaxDb | Q86W56 | |
| PRIDE | Q86W56 | |
| Ensembl | ENST00000402038 ENST00000616448 | |
| GeneID | 8505 | |
| KEGG | hsa:8505 | |
| UCSC | uc001jif.3 uc010qgx.2 | |
| CTD | 8505 | |
| GeneCards | GC10M051026 | |
| H-InvDB | HIX0127080 | |
| HGNC | HGNC:8605 | |
| HPA | HPA021819 | |
| MIM | 603501 | |
| neXtProt | NX_Q86W56 | |
| PharmGKB | PA32940 | |
| eggNOG | NOG254589 | |
| GeneTree | ENSGT00390000003652 | |
| HOVERGEN | HBG053510 | |
| InParanoid | Q86W56 | |
| KO | K07759 | |
| PhylomeDB | Q86W56 | |
| TreeFam | TF323527 | |
| ChiTaRS | PARG | |
| GeneWiki | PARG | |
| GenomeRNAi | 8505 | |
| NextBio | 31829 | |
| PMAP-CutDB | Q86W56 | |
| PRO | PR:Q86W56 | |
| Proteomes | UP000005640 | |
| Bgee | Q86W56 | |
| CleanEx | HS_PARG | |
| ExpressionAtlas | Q86W56 | |
| Genevestigator | Q86W56 | |
| GO | GO:0005737 GO:0005829 GO:0005759 GO:0005634 GO:0004649 GO:0005975 GO:0006974 GO:0016045 | |
| InterPro | IPR007724 | |
| PANTHER | PTHR12837 | |
| Pfam | PF05028 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000314 |
F |
Table 1 |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1. Autoradiographic evaluation of PARG activity in total and nuclear extracts from HeLa cells |
complete | |||||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990966 |
ATP generation from poly-ADP-D-ribose |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990966 |
ATP generation from poly-ADP-D-ribose |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000303269 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009225 |
nucleotide-sugar metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000303269 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006282 |
regulation of DNA repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000303269 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000303269 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023216 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347094 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004649 |
poly(ADP-ribose) glycohydrolase activity |
PMID:9925755[6] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5651828 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bernardi, R et al. (1997) Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells. Biochim. Biophys. Acta 1338 60-8 PubMed GONUTS page
- ↑ Rosenthal, F et al. (2013) Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nat. Struct. Mol. Biol. 20 502-7 PubMed GONUTS page
- ↑ Wright, RH et al. (2016) ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 352 1221-5 PubMed GONUTS page
- ↑ Putt, KS & Hergenrother, PJ (2004) A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation. Anal. Biochem. 333 256-64 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Winstall, E et al. (1999) Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein. Exp. Cell Res. 246 395-8 PubMed GONUTS page
