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HUMAN:PAR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) F2R (synonyms: CF2R, PAR1, TR)
Protein Name(s) Proteinase-activated receptor 1

PAR-1 Coagulation factor II receptor Thrombin receptor

External Links
UniProt P25116
EMBL M62424
AF391809
BT007279
BC002464
BC051909
CCDS CCDS4032.1
PIR A37912
RefSeq NP_001983.2
UniGene Hs.482562
PDB 1NRN
1NRO
1NRP
1NRQ
1NRR
3BEF
3HKI
3HKJ
3LU9
3VW7
PDBsum 1NRN
1NRO
1NRP
1NRQ
1NRR
3BEF
3HKI
3HKJ
3LU9
3VW7
ProteinModelPortal P25116
SMR P25116
BioGrid 108448
DIP DIP-29703N
IntAct P25116
STRING 9606.ENSP00000321326
BindingDB P25116
ChEMBL CHEMBL3974
DrugBank DB00086
GuidetoPHARMACOLOGY 347
PhosphoSite P25116
DMDM 20178318
MaxQB P25116
PaxDb P25116
PRIDE P25116
DNASU 2149
Ensembl ENST00000319211
GeneID 2149
KEGG hsa:2149
UCSC uc003ken.4
CTD 2149
GeneCards GC05P076047
H-InvDB HIX0004960
HGNC HGNC:3537
HPA CAB008973
MIM 187930
neXtProt NX_P25116
PharmGKB PA27946
eggNOG NOG150457
GeneTree ENSGT00760000119001
HOGENOM HOG000232200
HOVERGEN HBG108233
InParanoid P25116
KO K03914
OMA ASKMDTC
OrthoDB EOG7V49ZD
PhylomeDB P25116
TreeFam TF330775
Reactome REACT_14819
REACT_18283
REACT_21384
ChiTaRS F2R
EvolutionaryTrace P25116
GeneWiki Coagulation_factor_II_receptor
GenomeRNAi 2149
NextBio 8685
PMAP-CutDB P25116
PRO PR:P25116
Proteomes UP000005640
Bgee P25116
CleanEx HS_F2R
ExpressionAtlas P25116
Genevestigator P25116
GO GO:0005901
GO:0005769
GO:0005576
GO:0005794
GO:0005887
GO:0031594
GO:0005886
GO:0031094
GO:0045211
GO:0001965
GO:0031681
GO:0004930
GO:0005102
GO:0015057
GO:0006919
GO:0000186
GO:0009653
GO:0007596
GO:0002248
GO:0007529
GO:0007186
GO:0048873
GO:0006954
GO:0008285
GO:0003105
GO:0043524
GO:1900134
GO:0007200
GO:0030168
GO:0060155
GO:0030194
GO:0051928
GO:0030335
GO:0008284
GO:0032967
GO:0043280
GO:0007204
GO:0051482
GO:0070374
GO:0043123
GO:2000778
GO:2000484
GO:0046427
GO:0043410
GO:0014068
GO:0051281
GO:0035025
GO:0045987
GO:0045893
GO:0045907
GO:0007205
GO:0030193
GO:0032651
GO:0051930
GO:0051209
GO:0032496
GO:0009611
GO:0007262
GO:0007260
InterPro IPR000276
IPR017452
IPR003912
IPR000935
Pfam PF00001
PRINTS PR00237
PR01428
PR00908
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:23202369[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P61586)

Seeded From UniProt

complete

involved_in

GO:0045217

cell-cell junction maintenance

PMID:23202369[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000071)

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:24732013[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002618)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:24732013[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002618)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:24732013[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002618)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:22547407[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:22547407[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060155

platelet dense granule organization

PMID:1672265[4]

ECO:0000305

curator inference used in manual assertion

GO:0051281

P

Seeded From UniProt

complete

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

PMID:1672265[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:10692450[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

PMID:9639571[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031094

platelet dense tubular network

PMID:9038223[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:9701242[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030194

positive regulation of blood coagulation

PMID:9038223[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030193

regulation of blood coagulation

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

PMID:9038223[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

PMID:1672265[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

PMID:10692450[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

PMID:9639571[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:10692450[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:10692450[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

PMID:20164183[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:10692450[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005901

caveola

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9038223[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:1672265[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P25116

F

Seeded From UniProt

complete

involved_in

GO:0002248

connective tissue replacement involved in inflammatory response wound healing

PMID:9639571[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

PMID:11447194[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:17404307[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900134

negative regulation of renin secretion into blood stream

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0051930

regulation of sensory perception of pain

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0051928

positive regulation of calcium ion transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0048873

homeostasis of number of cells within a tissue

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0045987

positive regulation of smooth muscle contraction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

C

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0032651

regulation of interleukin-1 beta production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

enables

GO:0031681

G-protein beta-subunit binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

F

Seeded From UniProt

complete

part_of

GO:0031594

neuromuscular junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

C

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0007529

establishment of synaptic specificity at neuromuscular junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0007205

protein kinase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

F

Seeded From UniProt

complete

involved_in

GO:0003105

negative regulation of glomerular filtration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30558

F

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26824

P

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000660850
RGD:2586

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q9Y2T6

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000661114
UniProtKB:P25116

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1929509
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q99678
UniProtKB:Q9HC97
UniProtKB:Q9Y2T6

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
MGI:MGI:2441992
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q8IYL9
UniProtKB:Q99678
UniProtKB:Q9HC97

F

Seeded From UniProt

complete

involved_in

GO:1900134

negative regulation of renin secretion into blood stream

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0099553

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0070493

thrombin-activated receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0048873

homeostasis of number of cells within a tissue

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0032651

regulation of interleukin-1 beta production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

enables

GO:0031681

G-protein beta-subunit binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

F

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0030194

positive regulation of blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

F

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30558
ensembl:ENSMUSP00000061754

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000935

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000935

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000935
InterPro:IPR003912

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003912

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000935
InterPro:IPR003912
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0070493

thrombin-activated receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003912

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

PMID:9038223[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:9701242[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:1672265[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:7961693[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:17848177[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

Reactome:R-HSA-76002

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

Reactome:R-HSA-140875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-5607058
Reactome:R-HSA-418200
Reactome:R-HSA-418176
Reactome:R-HSA-418172
Reactome:R-HSA-418170
Reactome:R-HSA-418163
Reactome:R-HSA-418158
Reactome:R-HSA-418091
Reactome:R-HSA-397891
Reactome:R-HSA-397835
Reactome:R-HSA-396996
Reactome:R-HSA-389463
Reactome:R-HSA-379048
Reactome:R-HSA-114697
Reactome:R-HSA-114558
Reactome:R-HSA-114552

ECO:0000304

author statement supported by traceable reference used in manual assertion


















C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-114697

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page
  2. 2.0 2.1 2.2 Wang, YJ et al. (2014) Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. Biochim. Biophys. Acta 1843 1393-401 PubMed GONUTS page
  3. 3.0 3.1 Dores, MR et al. (2012) ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J. Cell Biol. 197 407-19 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Vu, TK et al. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057-68 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Huang, YQ et al. (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. J. Biol. Chem. 275 6462-8 PubMed GONUTS page
  7. 7.0 7.1 7.2 Chambers, RC et al. (1998) Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem. J. 333 ( Pt 1) 121-7 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Molino, M et al. (1997) Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. J. Biol. Chem. 272 6011-7 PubMed GONUTS page
  9. 9.0 9.1 Even-Ram, S et al. (1998) Thrombin receptor overexpression in malignant and physiological invasion processes. Nat. Med. 4 909-14 PubMed GONUTS page
  10. Swift, S et al. (2010) A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J. Biol. Chem. 285 11402-10 PubMed GONUTS page
  11. Lourbakos, A et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69 5121-30 PubMed GONUTS page
  12. Chiu, LL et al. (2007) Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178 5237-44 PubMed GONUTS page
  13. Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. Hein, L et al. (1994) Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J. Biol. Chem. 269 27719-26 PubMed GONUTS page