HUMAN:PAQRB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MMD (synonyms: PAQR11)
Protein Name(s)	Monocyte to macrophage differentiation factor Progestin and adipoQ receptor family member 11 Progestin and adipoQ receptor family member XI
External Links
UniProt	Q15546
EMBL	X85750 AY424289 CR541893 AK312760 CH471109 CH471109 BC026324
CCDS	CCDS11586.1
PIR	JC4503
RefSeq	NP_036461.2
UniGene	Hs.463483 Hs.656753
ProteinModelPortal	Q15546
BioGrid	117077
STRING	9606.ENSP00000262065
TCDB	9.B.30.2.1
PhosphoSite	Q15546
DMDM	62512174
PaxDb	Q15546
PRIDE	Q15546
DNASU	23531
Ensembl	ENST00000262065
GeneID	23531
KEGG	hsa:23531
UCSC	uc002iui.3
CTD	23531
GeneCards	GC17M053469
HGNC	HGNC:7153
MIM	604467
neXtProt	NX_Q15546
PharmGKB	PA30863
eggNOG	COG1272
GeneTree	ENSGT00390000001574
HOGENOM	HOG000039440
HOVERGEN	HBG053507
InParanoid	Q15546
KO	K11064
OMA	NNDAGSV
OrthoDB	EOG7SJD5B
PhylomeDB	Q15546
TreeFam	TF313370
GenomeRNAi	23531
NextBio	46010
PRO	PR:Q15546
Proteomes	UP000005640
Bgee	Q15546
CleanEx	HS_MMD
ExpressionAtlas	Q15546
Genevestigator	Q15546
GO	GO:0005887 GO:0031902 GO:0005765 GO:0016020 GO:0004872 GO:0019835
InterPro	IPR004254 IPR005744
PANTHER	PTHR20855
Pfam	PF03006
TIGRFAMs	TIGR01065

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005794	Golgi apparatus	PMID:21968647	ECO:0000314			C		When transiently transfected into Hela cells, N-terminally-tagged human PAQR10 and PAQR11 were both restricted to the Golgi apparatus and colocalized with Golgin-97, a Golgi marker (Figure 1A). …we found that the staining pattern of endogenous PAQR11 overlapped well with Golgin- 97 in A549 cells, which express high levels of PAQR11 (Figure 1B).	complete CACAO 2179
	GO:0045860	positive regulation of protein kinase activity	PMID:21968647	ECO:0000314			P		In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C). …the phosphorylation levels of ERK and p90RSK, a cytosolic target of ERK [40], were markedly reduced when both PAQR10 and PAQR11 were silenced (Figure 4A).	complete CACAO 2180
	GO:0032880	regulation of protein localization	PMID:21968647	ECO:0000314			P		when coexpressed with Flag-tagged PAQR10 or PAQR11, the localization of HRas in the Golgi apparatus was significantly increased with a clear colocalization with PAQR10/PAQR11 and Golgin-97 (Figure 2A). Overexpression of PAQR10/PAQR11 also markedly increased Golgi localization of NRas and KRas4A (Figure2B and 2C). In MDCK cells, PAQR10 also elevated Golgi localization of HRas, NRas and KRas4A, but not KRas4B (Supplementary information, Figure S7). (summarized in Figure 2E).	complete CACAO 2181
	GO:0004672	protein kinase activity	PMID:21968647	ECO:0000314			F		In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C).	complete CACAO 2182
	GO:0045666	positive regulation of neuron differentiation	PMID:21968647	ECO:0000314			P		When PAQR10 or PAQR11 was expressed in PC12 cells, either of them could significantly stimulate neurite outgrowth (Figure 7), a marker of PC12 cell differentiation.	complete CACAO 2183
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004254 InterPro:IPR005744	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005744	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7503749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7503749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:7503749	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C		Seeded From UniProt	complete
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References

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