HUMAN:PAQRA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MMD2 (synonyms: PAQR10)
Protein Name(s)	Monocyte to macrophage differentiation factor 2 Progestin and adipoQ receptor family member 10 Progestin and adipoQ receptor family member X
External Links
UniProt	Q8IY49
EMBL	AY424288 AC053546 AC092032 CH471144 BC037881 BC048346 BC067905
CCDS	CCDS47529.1 CCDS47530.1 CCDS59047.1
RefSeq	NP_001094070.1 NP_001257304.1 NP_940685.3
UniGene	Hs.558694
ProteinModelPortal	Q8IY49
STRING	9606.ENSP00000384690
DMDM	51701810
PaxDb	Q8IY49
PRIDE	Q8IY49
Ensembl	ENST00000401401 ENST00000404774 ENST00000406755 ENST00000612910
GeneID	221938
KEGG	hsa:221938
UCSC	uc003snn.4 uc003sno.4 uc010ksq.3
CTD	221938
GeneCards	GC07M004945
H-InvDB	HIX0201148
HGNC	HGNC:30133
HPA	HPA048714
MIM	614581
neXtProt	NX_Q8IY49
PharmGKB	PA134910250
eggNOG	COG1272
GeneTree	ENSGT00390000001574
HOGENOM	HOG000039440
HOVERGEN	HBG053507
InParanoid	Q8IY49
KO	K11064
OMA	MSHEKPL
OrthoDB	EOG7SJD5B
PhylomeDB	Q8IY49
TreeFam	TF313370
ChiTaRS	MMD2
GenomeRNAi	221938
NextBio	91508
PRO	PR:Q8IY49
Proteomes	UP000005640
Bgee	Q8IY49
CleanEx	HS_MMD2
Genevestigator	Q8IY49
GO	GO:0000139 GO:0016021 GO:0048471
InterPro	IPR004254
PANTHER	PTHR20855
Pfam	PF03006

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045860	positive regulation of protein kinase activity	PMID:21968647	ECO:0000314			P		In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C). …the phosphorylation levels of ERK and p90RSK, a cytosolic target of ERK [40], were markedly reduced when both PAQR10 and PAQR11 were silenced (Figure 4A).	complete CACAO 2185
	GO:0046579	positive regulation of Ras protein signal transduction	PMID:21968647	ECO:0000314			P		We also examined the expression levels of a few target genes downstream of ERK signaling, including c-Fos, JunB and Egr-1 . Consistently, overexpression of PAQR10 elevated the expression levels of these genes in a dose-dependent manner (Figure 1Ewe found that PAQR10-activated ERK phosphorylation was abrogated by inhibitors that were specific for the Ras signaling cascade (Figure 1F). The PAQR10- induced transcription of Egr-1 was blocked by GFPRBD and PD98059 (Supplementary information, Figure S5 and 7B).	complete CACAO 2186
	GO:0032880	regulation of protein localization	PMID:21968647	ECO:0000314			P		when coexpressed with Flag-tagged PAQR10 or PAQR11, the localization of HRas in the Golgi apparatus was significantly increased with a clear colocalization with PAQR10/PAQR11 and Golgin-97 (Figure 2A). Overexpression of PAQR10/PAQR11 also markedly increased Golgi localization of NRas and KRas4A (Figure2B and 2C). In MDCK cells, PAQR10 also elevated Golgi localization of HRas, NRas and KRas4A, but not KRas4B (Supplementary information, Figure S7). (summarized in Figure 2E).	complete CACAO 2187
	GO:0004672	protein kinase activity	PMID:21968647	ECO:0000314			F		In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C).	complete CACAO 2188
	GO:0045666	positive regulation of neuron differentiation	PMID:21968647	ECO:0000314			P		When PAQR10 or PAQR11 was expressed in PC12 cells, either of them could significantly stimulate neurite outgrowth (Figure 7), a marker of PC12 cell differentiation.	complete CACAO 2189
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:21968647	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:22500632	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004254	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
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References

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