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PMID:22500632

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Citation

Kang, P, Lee, HK, Glasgow, SM, Finley, M, Donti, T, Gaber, ZB, Graham, BH, Foster, AE, Novitch, BG, Gronostajski, RM and Deneen, B (2012) Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron 74:79-94

Abstract

Transcriptional cascades that operate over the course of lineage development are fundamental mechanisms that control cellular differentiation. In the developing central nervous system (CNS), these mechanisms are well characterized during neurogenesis, but remain poorly defined during neural stem cell commitment to the glial lineage. NFIA is a transcription factor that plays a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis. Subsequently, Sox9 and NFIA form a complex and coregulate a set of genes induced after glial initiation. Functional studies revealed that a subset of these genes, Apcdd1 and Mmd2, perform key migratory and metabolic roles during astro-gliogenesis, respectively. In sum, these studies delineate a transcriptional regulatory cascade that operates during the initiation of gliogenesis and identifies a unique set of genes that regulate key aspects of astro-glial precursor physiology during development.

Links

PubMed PMC3543821 Online version:10.1016/j.neuron.2012.01.024

Keywords

Animals; Cell Differentiation/physiology; Cell Lineage/physiology; Central Nervous System/cytology; Central Nervous System/embryology; Chick Embryo; Gene Expression Regulation, Developmental/physiology; Humans; Intracellular Signaling Peptides and Proteins/physiology; Membrane Proteins/physiology; Mice; NFI Transcription Factors/physiology; Neuroglia/cytology; Neuroglia/physiology; Organogenesis/physiology; SOX9 Transcription Factor/physiology; Stem Cells/cytology; Stem Cells/physiology; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SOX9

enables

GO:0000987: cis-regulatory region sequence-specific DNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:PAQRA

located_in

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PAQRA

located_in

GO:0048471: perinuclear region of cytoplasm

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:Q8IY49

C

Seeded From UniProt

complete

HUMAN:PAQRA

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:APCD1

acts_upstream_of_or_within

GO:0043615: astrocyte cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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