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HUMAN:PAPOA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PAPOLA (synonyms: PAP)
Protein Name(s) Poly(A) polymerase alpha

PAP-alpha Polynucleotide adenylyltransferase alpha

External Links
UniProt P51003
EMBL BC000927
BC036014
BX248301
BX248753
BX161482
X76770
CCDS CCDS58334.1
CCDS9946.1
RefSeq NP_001238935.1
NP_001238936.1
NP_001280556.1
NP_001280557.1
NP_001280561.1
NP_116021.2
UniGene Hs.253726
ProteinModelPortal P51003
SMR P51003
BioGrid 116119
DIP DIP-27610N
DIP-40865N
IntAct P51003
MINT MINT-125699
STRING 9606.ENSP00000216277
PhosphoSite P51003
DMDM 59803092
MaxQB P51003
PaxDb P51003
PeptideAtlas P51003
PRIDE P51003
Ensembl ENST00000216277
ENST00000557320
ENST00000557471
GeneID 10914
KEGG hsa:10914
UCSC uc001yfo.3
uc001yfq.3
CTD 10914
GeneCards GC14P096969
HGNC HGNC:14981
HPA HPA001788
MIM 605553
neXtProt NX_P51003
PharmGKB PA32932
eggNOG COG5186
GeneTree ENSGT00390000017928
HOVERGEN HBG053502
InParanoid P51003
KO K14376
OMA SPVTTQG
OrthoDB EOG7XH6PT
PhylomeDB P51003
TreeFam TF300842
Reactome REACT_1096
REACT_1849
REACT_467
ChiTaRS PAPOLA
GeneWiki PAPOLA
GenomeRNAi 10914
NextBio 41453
PRO PR:P51003
Proteomes UP000005640
Bgee P51003
CleanEx HS_PAPOLA
ExpressionAtlas P51003
Genevestigator P51003
GO GO:0005737
GO:0005654
GO:0005634
GO:0005524
GO:0000287
GO:0030145
GO:0004652
GO:0003723
GO:0010467
GO:0031124
GO:0000398
GO:0043631
GO:0008380
GO:0006369
GO:0006366
Gene3D 3.30.70.590
InterPro IPR002934
IPR011068
IPR007012
IPR007010
IPR014492
Pfam PF01909
PF04928
PF04926
PIRSF PIRSF018425
SUPFAM SSF55003

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0031440

regulation of mRNA 3'-end processing

PMID:19224921[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006378

mRNA polyadenylation

PMID:19224921[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006378

mRNA polyadenylation

PMID:7590244[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

PMID:7590244[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043631

RNA polyadenylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25500

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25500

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25500

F

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25500

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25500

F

Seeded From UniProt

complete

involved_in

GO:0006378

mRNA polyadenylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000074206
PomBase:SPBC646.04
SGD:S000001710
UniProtKB:P51003

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1932115
PANTHER:PTN000074213

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1932115
PANTHER:PTN000074206
PomBase:SPBC646.04
TAIR:locus:2030943
TAIR:locus:2043560
TAIR:locus:2134113
UniProtKB:Q9BWT3

C

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109301
PANTHER:PTN000074206
PomBase:SPBC646.04
SGD:S000001710
UniProtKB:A0A0B4KG96
UniProtKB:P25500
UniProtKB:P51003
UniProtKB:Q9BWT3

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043631

RNA polyadenylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61183
ensembl:ENSMUSP00000105527

P

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61183
ensembl:ENSMUSP00000105527

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007010
InterPro:IPR011068

F

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007012
InterPro:IPR014492

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014492

C

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002934
InterPro:IPR011068

F

Seeded From UniProt

complete

involved_in

GO:0031123

RNA 3'-end processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011068

P

Seeded From UniProt

complete

involved_in

GO:0043631

RNA polyadenylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007010
InterPro:IPR007012
InterPro:IPR014492

P

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.19

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8302877[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8302877[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

Reactome:R-HSA-75067
Reactome:R-HSA-72187

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006369

termination of RNA polymerase II transcription

Reactome:R-HSA-109688

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8849157
Reactome:R-HSA-77593
Reactome:R-HSA-77592
Reactome:R-HSA-77591
Reactome:R-HSA-72231
Reactome:R-HSA-72185
Reactome:R-HSA-72180
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

enables

GO:0004652

polynucleotide adenylyltransferase activity

Reactome:R-HSA-72185

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Kiefer, H et al. (2009) Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. J. Biol. Chem. 284 10694-705 PubMed GONUTS page
  2. ↑ 2.0 2.1 Murthy, KG & Manley, JL (1995) The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Genes Dev. 9 2672-83 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Thuresson, AC et al. (1994) Multiple forms of poly(A) polymerases in human cells. Proc. Natl. Acad. Sci. U.S.A. 91 979-83 PubMed GONUTS page
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