GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:PALB2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PALB2 (synonyms: FANCN)
Protein Name(s) Partner and localizer of BRCA2
External Links
UniProt Q86YC2
EMBL AL834425
CR749637
AC008870
CH471145
BC044254
AK025469
AK097533
CCDS CCDS32406.1
RefSeq NP_078951.2
UniGene Hs.444664
PDB 2W18
3EU7
PDBsum 2W18
3EU7
ProteinModelPortal Q86YC2
SMR Q86YC2
BioGrid 122843
DIP DIP-38427N
IntAct Q86YC2
MINT MINT-7262182
STRING 9606.ENSP00000261584
PhosphoSite Q86YC2
DMDM 74727919
MaxQB Q86YC2
PaxDb Q86YC2
PRIDE Q86YC2
DNASU 79728
Ensembl ENST00000261584
GeneID 79728
KEGG hsa:79728
UCSC uc002dlx.1
CTD 79728
GeneCards GC16M023614
GeneReviews PALB2
HGNC HGNC:26144
HPA CAB014895
HPA057000
MIM 114480
227650
610355
610832
613348
neXtProt NX_Q86YC2
Orphanet 1333
84
145
PharmGKB PA162398608
eggNOG NOG73403
GeneTree ENSGT00390000014423
HOGENOM HOG000115428
HOVERGEN HBG082102
InParanoid Q86YC2
KO K10897
OMA NIVIWNL
OrthoDB EOG72C51Z
PhylomeDB Q86YC2
TreeFam TF351544
Reactome REACT_18410
EvolutionaryTrace Q86YC2
GeneWiki PALB2
GenomeRNAi 79728
NextBio 69102
PRO PR:Q86YC2
Proteomes UP000005640
Bgee Q86YC2
CleanEx HS_PALB2
ExpressionAtlas Q86YC2
Genevestigator Q86YC2
GO GO:0005654
GO:0005634
GO:0003677
GO:0006281
GO:0000724
GO:0001833
GO:0007498
GO:0043066
GO:0009887
GO:0036342
GO:0001756
Gene3D 2.130.10.10
InterPro IPR015943
IPR017986
SUPFAM SSF50978

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:26323318[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:20871616[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:19423707[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:19369211[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048568

embryonic organ development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0036342

post-anal tail morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0035264

multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0001833

inner cell mass cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0001756

somitogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U0P1
ensembl:ENSMUSP00000095675

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5693620
Reactome:R-HSA-5693593
Reactome:R-HSA-5693589
Reactome:R-HSA-5693584
Reactome:R-HSA-5693539
Reactome:R-HSA-5686483
Reactome:R-HSA-5686469
Reactome:R-HSA-5686440
Reactome:R-HSA-5686410
Reactome:R-HSA-5685838

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Parplys, AC et al. (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 43 9817-34 PubMed GONUTS page
  2. ↑ Dray, E et al. (2010) Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat. Struct. Mol. Biol. 17 1255-9 PubMed GONUTS page
  3. ↑ Sy, SM et al. (2009) PALB2 regulates recombinational repair through chromatin association and oligomerization. J. Biol. Chem. 284 18302-10 PubMed GONUTS page
  4. ↑ Sy, SM et al. (2009) PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc. Natl. Acad. Sci. U.S.A. 106 7155-60 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:PALB2&oldid=5956514"