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HUMAN:PAF1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PAF1 (synonyms: PD2) | |
| Protein Name(s) | RNA polymerase II-associated factor 1 homolog
hPAF1 Pancreatic differentiation protein 2 | |
| External Links | ||
| UniProt | Q8N7H5 | |
| EMBL | AJ401156 AK001985 AK098423 AC005239 CH471126 CH471126 CH471126 BC000017 BC013402 | |
| CCDS | CCDS12533.1 CCDS59387.1 | |
| RefSeq | NP_001243755.1 NP_061961.2 | |
| UniGene | Hs.466714 | |
| PDB | 4M6T | |
| PDBsum | 4M6T | |
| ProteinModelPortal | Q8N7H5 | |
| SMR | Q8N7H5 | |
| BioGrid | 120081 | |
| DIP | DIP-48673N | |
| IntAct | Q8N7H5 | |
| STRING | 9606.ENSP00000221265 | |
| DMDM | 182670295 | |
| MaxQB | Q8N7H5 | |
| PaxDb | Q8N7H5 | |
| PRIDE | Q8N7H5 | |
| Ensembl | ENST00000221265 ENST00000595564 | |
| GeneID | 54623 | |
| KEGG | hsa:54623 | |
| UCSC | uc002old.4 | |
| CTD | 54623 | |
| GeneCards | GC19M039876 | |
| HGNC | HGNC:25459 | |
| HPA | HPA041875 | |
| MIM | 610506 | |
| neXtProt | NX_Q8N7H5 | |
| PharmGKB | PA142671206 | |
| eggNOG | NOG297168 | |
| GeneTree | ENSGT00390000001474 | |
| HOGENOM | HOG000115425 | |
| HOVERGEN | HBG053131 | |
| InParanoid | Q8N7H5 | |
| KO | K15174 | |
| OMA | VEMMSQA | |
| PhylomeDB | Q8N7H5 | |
| TreeFam | TF313642 | |
| ChiTaRS | PAF1 | |
| GenomeRNAi | 54623 | |
| NextBio | 57158 | |
| PRO | PR:Q8N7H5 | |
| Proteomes | UP000005640 | |
| Bgee | Q8N7H5 | |
| CleanEx | HS_PAF1 | |
| ExpressionAtlas | Q8N7H5 | |
| Genevestigator | Q8N7H5 | |
| GO | GO:0016593 GO:0003682 GO:0000993 GO:0071222 GO:0001711 GO:0033523 GO:0010390 GO:0006378 GO:0045638 GO:0000122 GO:0031442 GO:0032968 GO:0045944 GO:0019827 GO:0006351 GO:0016055 | |
| InterPro | IPR007133 | |
| PANTHER | PTHR23188 | |
| Pfam | PF03985 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Fig. 2B, 5A |
complete | ||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Fig. 5A |
complete | ||||
| GO:0031062 |
positive regulation of histone methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 1 and Fig. 2 |
complete | ||||
| GO:0034504 |
protein localization to nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 5AB |
complete | ||||
| GO:0034728 |
nucleosome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 6: hPaf1/PD2 knockdown performed in pancreatic cancer cells (GO term updated - see Discussion page) |
complete | ||||
| GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 2A and Fig. 3AB and Fig. S1A |
complete | ||||
| GO:0045727 |
positive regulation of translation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 2A and Fig. 3AB and Fig. S1A |
complete | ||||
| GO:1900182 |
positive regulation of protein localization to nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig. 5AB; facilitates the localization of CHD1 to nucleus |
complete | ||||
|
involved_in |
GO:1902808 |
positive regulation of cell cycle G1/S phase transition |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034504 |
protein localization to nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031062 |
positive regulation of histone methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045638 |
negative regulation of myeloid cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033523 |
histone H2B ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031442 |
positive regulation of mRNA 3'-end processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016593 |
Cdc73/Paf1 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016593 |
Cdc73/Paf1 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010390 |
histone monoubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006378 |
mRNA polyadenylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001711 |
endodermal cell fate commitment |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000993 |
RNA polymerase II complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035327 |
transcriptionally active chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010750 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016593 |
Cdc73/Paf1 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010750 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1923988 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000993 |
RNA polymerase II complex binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000573292 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019827 |
stem cell population maintenance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016593 |
Cdc73/Paf1 complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001711 |
endodermal cell fate commitment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K2T8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016570 |
histone modification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016593 |
Cdc73/Paf1 complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
Reactome:R-HSA-8866654 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
Reactome:R-HSA-75955 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
Reactome:R-HSA-73857 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8942101 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Dey, P et al. (2011) Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS ONE 6 e26926 PubMed GONUTS page
- ↑ 2.0 2.1 Yart, A et al. (2005) The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol. Cell. Biol. 25 5052-60 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kim, J et al. (2010) The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell 140 491-503 PubMed GONUTS page
- ↑ Muntean, AG et al. (2010) The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17 609-21 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Zhu, B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20 601-11 PubMed GONUTS page
- ↑ 6.0 6.1 Nagaike, T et al. (2011) Transcriptional activators enhance polyadenylation of mRNA precursors. Mol. Cell 41 409-18 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:1902808 ! positive regulation of cell cycle G1/S phase transition
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0032968 ! positive regulation of transcription elongation by RNA polymerase II
- GO:0031442 ! positive regulation of mRNA 3'-end processing
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:1900182 ! positive regulation of protein localization to nucleus
- GO:0045727 ! positive regulation of translation
- Primates
- GO:0034504 ! protein localization to nucleus
- GO:0016567 ! protein ubiquitination
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