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HUMAN:PAF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PAF1 (synonyms: PD2)
Protein Name(s) RNA polymerase II-associated factor 1 homolog

hPAF1 Pancreatic differentiation protein 2

External Links
UniProt Q8N7H5
EMBL AJ401156
AK001985
AK098423
AC005239
CH471126
CH471126
CH471126
BC000017
BC013402
CCDS CCDS12533.1
CCDS59387.1
RefSeq NP_001243755.1
NP_061961.2
UniGene Hs.466714
PDB 4M6T
PDBsum 4M6T
ProteinModelPortal Q8N7H5
SMR Q8N7H5
BioGrid 120081
DIP DIP-48673N
IntAct Q8N7H5
STRING 9606.ENSP00000221265
DMDM 182670295
MaxQB Q8N7H5
PaxDb Q8N7H5
PRIDE Q8N7H5
Ensembl ENST00000221265
ENST00000595564
GeneID 54623
KEGG hsa:54623
UCSC uc002old.4
CTD 54623
GeneCards GC19M039876
HGNC HGNC:25459
HPA HPA041875
MIM 610506
neXtProt NX_Q8N7H5
PharmGKB PA142671206
eggNOG NOG297168
GeneTree ENSGT00390000001474
HOGENOM HOG000115425
HOVERGEN HBG053131
InParanoid Q8N7H5
KO K15174
OMA VEMMSQA
PhylomeDB Q8N7H5
TreeFam TF313642
ChiTaRS PAF1
GenomeRNAi 54623
NextBio 57158
PRO PR:Q8N7H5
Proteomes UP000005640
Bgee Q8N7H5
CleanEx HS_PAF1
ExpressionAtlas Q8N7H5
Genevestigator Q8N7H5
GO GO:0016593
GO:0003682
GO:0000993
GO:0071222
GO:0001711
GO:0033523
GO:0010390
GO:0006378
GO:0045638
GO:0000122
GO:0031442
GO:0032968
GO:0045944
GO:0019827
GO:0006351
GO:0016055
InterPro IPR007133
PANTHER PTHR23188
Pfam PF03985

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016020

membrane

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Fig. 2B, 5A

complete
CACAO 2705

GO:0005737

cytoplasm

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Fig. 5A

complete
CACAO 2706

GO:0031062

positive regulation of histone methylation

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 1 and Fig. 2

complete
CACAO 2708

GO:0034504

protein localization to nucleus

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 5AB

complete
CACAO 2710

GO:0016584

nucleosome positioning

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 6

complete
CACAO 2711

GO:0045893

positive regulation of transcription, DNA-templated

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 2A and Fig. 3AB and Fig. S1A

complete

GO:0045727

positive regulation of translation

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 2A and Fig. 3AB and Fig. S1A

complete

GO:1900182

positive regulation of protein localization to nucleus

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Fig. 5AB; facilitates the localization of CHD1 to nucleus

complete

involved_in

GO:1902808

positive regulation of cell cycle G1/S phase transition

PMID:15923622[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016584

nucleosome positioning

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034504

protein localization to nucleus

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031062

positive regulation of histone methylation

PMID:22046413[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2T8

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20178742[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045638

negative regulation of myeloid cell differentiation

PMID:20541477[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033523

histone H2B ubiquitination

PMID:16307923[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:20178742[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031442

positive regulation of mRNA 3'-end processing

PMID:21329879[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:20178742[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:16307923[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010390

histone monoubiquitination

PMID:16307923[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006378

mRNA polyadenylation

PMID:21329879[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001711

endodermal cell fate commitment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2T8

P

Seeded From UniProt

complete

enables

GO:0000993

RNA polymerase II complex binding

PMID:15923622[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K2T8

P

Seeded From UniProt

complete

part_of

GO:0035327

transcriptionally active chromatin

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010750
PANTHER:PTN000573292
SGD:S000000483

C

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010750
PANTHER:PTN000573292
PomBase:SPAC664.03
SGD:S000000483
UniProtKB:Q8N7H5

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1923988
PANTHER:PTN000573292
SGD:S000000483

F

Seeded From UniProt

complete

enables

GO:0000993

RNA polymerase II complex binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000573292
SGD:S000000483
UniProtKB:Q8N7H5

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

P

Seeded From UniProt

complete

involved_in

GO:0019827

stem cell population maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

P

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

F

Seeded From UniProt

complete

involved_in

GO:0001711

endodermal cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K2T8
ensembl:ENSMUSP00000003529

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007133

P

Seeded From UniProt

complete

involved_in

GO:0016570

histone modification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007133

P

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007133

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

Reactome:R-HSA-8866654

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

Reactome:R-HSA-75955
Reactome:R-HSA-112382

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

Reactome:R-HSA-73857

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8942101
Reactome:R-HSA-8942099
Reactome:R-HSA-113429
Reactome:R-HSA-113414
Reactome:R-HSA-113413
Reactome:R-HSA-113412
Reactome:R-HSA-113411
Reactome:R-HSA-112396
Reactome:R-HSA-112395
Reactome:R-HSA-112392
Reactome:R-HSA-112385
Reactome:R-HSA-112379

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Dey, P et al. (2011) Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS ONE 6 e26926 PubMed GONUTS page
  2. 2.0 2.1 Yart, A et al. (2005) The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol. Cell. Biol. 25 5052-60 PubMed GONUTS page
  3. 3.0 3.1 3.2 Kim, J et al. (2010) The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell 140 491-503 PubMed GONUTS page
  4. Muntean, AG et al. (2010) The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17 609-21 PubMed GONUTS page
  5. 5.0 5.1 5.2 Zhu, B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20 601-11 PubMed GONUTS page
  6. 6.0 6.1 Nagaike, T et al. (2011) Transcriptional activators enhance polyadenylation of mRNA precursors. Mol. Cell 41 409-18 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page