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HUMAN:PADI2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PADI2 (synonyms: KIAA0994, PDI2)
Protein Name(s) Protein-arginine deiminase type-2

PAD-H19 Peptidylarginine deiminase II Protein-arginine deiminase type II

External Links
UniProt Q9Y2J8
EMBL AB030176
AJ549502
AB023211
AL049569
BC009701
CCDS CCDS177.1
RefSeq NP_031391.2
UniGene Hs.33455
ProteinModelPortal Q9Y2J8
SMR Q9Y2J8
BioGrid 116404
IntAct Q9Y2J8
STRING 9606.ENSP00000364635
BindingDB Q9Y2J8
ChEMBL CHEMBL1909487
DrugBank DB00155
PhosphoSite Q9Y2J8
DMDM 7531171
MaxQB Q9Y2J8
PaxDb Q9Y2J8
PRIDE Q9Y2J8
Ensembl ENST00000375481
ENST00000375486
GeneID 11240
KEGG hsa:11240
UCSC uc001baf.3
CTD 11240
GeneCards GC01M017393
HGNC HGNC:18341
HPA CAB012222
MIM 607935
neXtProt NX_Q9Y2J8
PharmGKB PA32900
eggNOG NOG42085
GeneTree ENSGT00390000008680
HOGENOM HOG000220908
HOVERGEN HBG053016
InParanoid Q9Y2J8
KO K01481
OMA CLETHVR
OrthoDB EOG7P5T09
PhylomeDB Q9Y2J8
TreeFam TF331952
BioCyc MetaCyc:HS04094-MONOMER
BRENDA 3.5.3.15
ChiTaRS PADI2
GeneWiki PADI2
GenomeRNAi 11240
NextBio 42778
PRO PR:Q9Y2J8
Proteomes UP000005640
Bgee Q9Y2J8
CleanEx HS_PADI2
ExpressionAtlas Q9Y2J8
Genevestigator Q9Y2J8
GO GO:0005737
GO:0070062
GO:0035327
GO:0005509
GO:0030331
GO:0004668
GO:0048096
GO:0036413
GO:0030520
GO:0070100
GO:1901624
GO:0018101
GO:0010848
GO:0021762
InterPro IPR008972
IPR004303
IPR013530
IPR013732
IPR013733
IPR016296
PANTHER PTHR10837
Pfam PF03068
PF08527
PF08526
PIRSF PIRSF001247
SUPFAM SSF110083
SSF49503

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004668

protein-arginine deiminase activity

PMID:25621824[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:25621824[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:25621824[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018101

protein citrullination

PMID:25621824[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901624

negative regulation of lymphocyte chemotaxis

PMID:18645041[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070100

negative regulation of chemokine-mediated signaling pathway

PMID:18645041[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0048096

chromatin-mediated maintenance of transcription

PMID:22853951[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036413

histone H3-R26 citrullination

PMID:22853951[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035327

transcriptionally active chromatin

PMID:22853951[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

PMID:22853951[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030331

estrogen receptor binding

PMID:22853951[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03372

F

Seeded From UniProt

complete

involved_in

GO:0021762

substantia nigra development

PMID:22926577[5]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018101

protein citrullination

PMID:12392711[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018101

protein citrullination

PMID:15629448[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010848

regulation of chromatin disassembly

PMID:22853951[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12392711[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002025)
  • part_of:(CL:0000312)|part_of:(UBERON:0002026)
  • part_of:(CL:0000312)|part_of:(UBERON:0002069)
  • part_of:(CL:0000312)

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

PMID:18645041[2]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P02778)

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

PMID:12392711[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

PMID:15629448[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

PMID:22853951[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0036414

histone citrullination

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338898
PANTHER:PTN000851400
UniProtKB:Q9UM07

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2655198
PANTHER:PTN000851400
UniProtKB:Q6TGC4
UniProtKB:Q9ULW8
UniProtKB:Q9Y2J8

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000851400
UniProtKB:Q9UM07

C

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338898
MGI:MGI:2655198
PANTHER:PTN000851400
RGD:3287
RGD:3288
RGD:3289
RGD:3290
UniProtKB:E1C0W6
UniProtKB:F1NP39
UniProtKB:Q9ULW8
UniProtKB:Q9UM07
UniProtKB:Q9Y2J8

F

Seeded From UniProt

complete

involved_in

GO:1990830

cellular response to leukemia inhibitory factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08642
ensembl:ENSMUSP00000030765

P

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004303
InterPro:IPR013530
InterPro:IPR013732
InterPro:IPR013733
InterPro:IPR036556

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013530
InterPro:IPR013732
InterPro:IPR013733
InterPro:IPR036556

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013530
InterPro:IPR013732
InterPro:IPR013733
InterPro:IPR036556

C

Seeded From UniProt

complete

involved_in

GO:0018101

protein citrullination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004303
InterPro:IPR013733
InterPro:IPR036556

P

Seeded From UniProt

complete

enables

GO:0004668

protein-arginine deiminase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.3.15

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035578

azurophil granule lumen

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

Reactome:R-HSA-4839726

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1183128

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Slade, DJ et al. (2015) Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem. Biol. 10 1043-53 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Loos, T et al. (2008) Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood 112 2648-56 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Zhang, X et al. (2012) Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proc. Natl. Acad. Sci. U.S.A. 109 13331-6 PubMed GONUTS page
  5. ↑ Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Ishigami, A et al. (2002) Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch. Biochem. Biophys. 407 25-31 PubMed GONUTS page
  7. ↑ 7.0 7.1 Nakayama-Hamada, M et al. (2005) Comparison of enzymatic properties between hPADI2 and hPADI4. Biochem. Biophys. Res. Commun. 327 192-200 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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