HUMAN:OXYR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	OXTR
Protein Name(s)	Oxytocin receptor OT-R
External Links
UniProt	P30559
EMBL	X64878 AY389507 X80282
CCDS	CCDS2570.1
PIR	A55493
RefSeq	NP_000907.2
UniGene	Hs.2820
ProteinModelPortal	P30559
SMR	P30559
BioGrid	111061
STRING	9606.ENSP00000324270
BindingDB	P30559
ChEMBL	CHEMBL2049
DrugBank	DB01282 DB00107
GuidetoPHARMACOLOGY	369
PhosphoSite	P30559
DMDM	143811431
MaxQB	P30559
PaxDb	P30559
PRIDE	P30559
Ensembl	ENST00000316793
GeneID	5021
KEGG	hsa:5021
UCSC	uc003brc.3
CTD	5021
GeneCards	GC03M008767
H-InvDB	HIX0030783
HGNC	HGNC:8529
HPA	CAB022700
MIM	167055
neXtProt	NX_P30559
PharmGKB	PA32858
eggNOG	NOG299951
GeneTree	ENSGT00760000119156
HOGENOM	HOG000237331
HOVERGEN	HBG105710
InParanoid	P30559
KO	K04229
OMA	GPPRRNE
OrthoDB	EOG7Z69CP
PhylomeDB	P30559
TreeFam	TF106499
Reactome	REACT_17041 REACT_18283
SignaLink	P30559
GeneWiki	Oxytocin_receptor
GenomeRNAi	5021
NextBio	19332
PRO	PR:P30559
Proteomes	UP000005640
Bgee	P30559
CleanEx	HS_OXTR
ExpressionAtlas	P30559
Genevestigator	P30559
GO	GO:0016324 GO:0005913 GO:0005887 GO:0005902 GO:0005886 GO:0004990 GO:0017046 GO:0005000 GO:0007166 GO:0048565 GO:0042755 GO:0070371 GO:0007565 GO:0007507 GO:0007595 GO:0042711 GO:0060137 GO:0007613 GO:0006936 GO:0060455 GO:0045777 GO:0007204 GO:0010701 GO:0060406 GO:0051965 GO:0032230 GO:0051968 GO:0070474 GO:0001975 GO:0034059 GO:0042220 GO:0034097 GO:0042493 GO:0032355 GO:0043434 GO:0032570 GO:0030431 GO:0035176 GO:0042713 GO:0001967 GO:0021537
InterPro	IPR000276 IPR017452 IPR002062 IPR001817
Pfam	PF00001
PRINTS	PR00237 PR00665 PR00896
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004990	oxytocin receptor activity	PMID:7798245^[1]	ECO:0000255		UniProtKB:P30559	F	FIG.1.Organization of the human oxytocin receptor gene	complete CACAO 10389
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24002032^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97926	P	Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662574 RGD:2185	P	Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662660 RGD:3239	P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662660 RGD:3239	P	Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001202348 RGD:2289	P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662660 RGD:3239	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025595 PANTHER:PTN001202348 RGD:3239 RGD:61886 RGD:70513 ZFIN:ZDB-GENE-050419-76 ZFIN:ZDB-GENE-090128-3	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038880 PANTHER:PTN001202348	C	Seeded From UniProt	complete
enables	GO:0005000	vasopressin receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001202415 RGD:2185 RGD:61886	F	Seeded From UniProt	complete
enables	GO:0004990	oxytocin receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662657 RGD:3239	F	Seeded From UniProt	complete
involved_in	GO:0001992	regulation of systemic arterial blood pressure by vasopressin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347010 MGI:MGI:1859216 PANTHER:PTN000662574	P	Seeded From UniProt	complete
involved_in	GO:0070474	positive regulation of uterine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0060455	negative regulation of gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0060406	positive regulation of penile erection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0044058	regulation of digestive system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0042713	sperm ejaculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0034059	response to anoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0030431	sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
enables	GO:0017046	peptide hormone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	C	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0010701	positive regulation of norepinephrine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	C	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	C	Seeded From UniProt	complete
enables	GO:0004990	oxytocin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	F	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0001967	suckling behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70536 ensembl:ENSRNOP00000007724	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97926 ensembl:ENSMUSP00000051132	P	Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97926 ensembl:ENSMUSP00000051132	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004990	oxytocin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002062	F	Seeded From UniProt	complete
enables	GO:0005000	vasopressin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001817	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001817 InterPro:IPR002062	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001817 InterPro:IPR002062 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007595	lactation	PMID:1313946^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:1313946^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:1313946^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:1313946^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10858434^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10910058^[6] PMID:10858434^[5] Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-388503 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004990	oxytocin receptor activity	PMID:10858434^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Inoue, T et al. (1994) Structural organization of the human oxytocin receptor gene. J. Biol. Chem. 269 32451-6 PubMed GONUTS page
↑ Kasahara, Y et al. (2013) Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology 154 4305-15 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Kimura, T et al. (1992) Structure and expression of a human oxytocin receptor. Nature 356 526-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Berrada, K et al. (2000) Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. J. Biol. Chem. 275 27229-37 PubMed GONUTS page
↑ Novak, JF et al. (2000) A plasmin-derived hexapeptide from the carboxyl end of osteocalcin counteracts oxytocin-mediated growth inhibition [corrected] of osteosarcoma cells. Cancer Res. 60 3470-6 PubMed GONUTS page

[PMID:7798245-1] Inoue, T et al. (1994) Structural organization of the human oxytocin receptor gene. J. Biol. Chem. 269 32451-6 PubMed GONUTS page

[PMID:24002032-2] Kasahara, Y et al. (2013) Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology 154 4305-15 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1313946-4] 4.0 ^4.1 ^4.2 ^4.3 Kimura, T et al. (1992) Structure and expression of a human oxytocin receptor. Nature 356 526-9 PubMed GONUTS page

[PMID:10858434-5] 5.0 ^5.1 ^5.2 Berrada, K et al. (2000) Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. J. Biol. Chem. 275 27229-37 PubMed GONUTS page

[PMID:10910058-6] Novak, JF et al. (2000) A plasmin-derived hexapeptide from the carboxyl end of osteocalcin counteracts oxytocin-mediated growth inhibition [corrected] of osteosarcoma cells. Cancer Res. 60 3470-6 PubMed GONUTS page

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HUMAN:OXYR

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