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HUMAN:ONCM
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | OSM | |
| Protein Name(s) | Oncostatin-M
OSM | |
| External Links | ||
| UniProt | P13725 | |
| EMBL | M27288 M27286 M27287 CR456534 CR541703 AC004264 CH471095 BC011589 | |
| CCDS | CCDS13873.1 | |
| PIR | A32489 | |
| RefSeq | NP_065391.1 | |
| UniGene | Hs.248156 | |
| PDB | 1EVS | |
| PDBsum | 1EVS | |
| ProteinModelPortal | P13725 | |
| BioGrid | 111049 | |
| DIP | DIP-5785N | |
| IntAct | P13725 | |
| MINT | MINT-1352068 | |
| STRING | 9606.ENSP00000215781 | |
| PhosphoSite | P13725 | |
| DMDM | 129168 | |
| PaxDb | P13725 | |
| PRIDE | P13725 | |
| DNASU | 5008 | |
| Ensembl | ENST00000215781 | |
| GeneID | 5008 | |
| KEGG | hsa:5008 | |
| UCSC | uc003ahb.3 | |
| CTD | 5008 | |
| GeneCards | GC22M030658 | |
| HGNC | HGNC:8506 | |
| HPA | HPA029814 | |
| MIM | 165095 | |
| neXtProt | NX_P13725 | |
| PharmGKB | PA32836 | |
| eggNOG | NOG39662 | |
| GeneTree | ENSGT00390000004850 | |
| HOGENOM | HOG000074128 | |
| HOVERGEN | HBG007867 | |
| InParanoid | P13725 | |
| KO | K05418 | |
| OMA | GYHRFMH | |
| OrthoDB | EOG7NGQC9 | |
| PhylomeDB | P13725 | |
| TreeFam | TF338204 | |
| SignaLink | P13725 | |
| EvolutionaryTrace | P13725 | |
| GeneWiki | Oncostatin_M | |
| GenomeRNAi | 5008 | |
| NextBio | 19284 | |
| PMAP-CutDB | P13725 | |
| PRO | PR:P13725 | |
| Proteomes | UP000005640 | |
| Bgee | P13725 | |
| CleanEx | HS_OSM | |
| ExpressionAtlas | P13725 | |
| Genevestigator | P13725 | |
| GO | GO:0005615 GO:0005125 GO:0008083 GO:0005147 GO:0048266 GO:0008283 GO:0006955 GO:0007275 GO:0008285 GO:0046888 GO:0045835 GO:0038165 GO:0007422 GO:0002675 GO:2001235 GO:0051781 GO:0008284 GO:0043410 GO:0033138 GO:0050731 GO:0045944 GO:0040008 GO:0009408 GO:0042508 GO:0042503 GO:0042506 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR001581 IPR019827 | |
| Pfam | PF01291 | |
| SMART | SM00080 | |
| SUPFAM | SSF47266 | |
| PROSITE | PS00590 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 6 - OsM shows positive regulation of STAT3 phosphorylation. |
complete | |||||
|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS0000574A2C_9606 |
P |
occurs_in:(CL:0000492) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS0000574A2C_9606 |
P |
occurs_in:(CL:0000492) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:1905078 |
positive regulation of interleukin-17 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000492) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000492) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038165 |
oncostatin-M-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002675 |
positive regulation of acute inflammatory response |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046888 |
negative regulation of hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038165 |
oncostatin-M-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902036 |
regulation of hematopoietic stem cell differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6789615 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Chang, R et al. (2018) MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. Br J Ophthalmol 102 282-290 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Mosley, B et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271 32635-43 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Yin, T & Yang, YC (1994) Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269 3731-8 PubMed GONUTS page
- ↑ Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page
- ↑ 7.0 7.1 Rose, TM & Bruce, AG (1991) Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. 88 8641-5 PubMed GONUTS page
- ↑ Miles, SA et al. (1992) Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255 1432-4 PubMed GONUTS page
- ↑ 9.0 9.1 Malik, N et al. (1989) Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M. Mol. Cell. Biol. 9 2847-53 PubMed GONUTS page
- ↑ Tanaka, M et al. (1999) Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood 93 804-15 PubMed GONUTS page
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- GO:0042517 ! positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0051781 ! positive regulation of cell division
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0002675 ! positive regulation of acute inflammatory response
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0050729 ! positive regulation of inflammatory response
- GO:1905078 ! positive regulation of interleukin-17 secretion
- Primates
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