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PMID:1542793

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Citation

Miles, SA, Martínez-Maza, O, Rezai, A, Magpantay, L, Kishimoto, T, Nakamura, S, Radka, SF and Linsley, PS (1992) Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255:1432-4

Abstract

Oncostatin M, a cytokine produced by activated lymphoid cells, regulates the growth and differentiation of a number of tumor and normal cells. In contrast to its effects on normal endothelial and aortic smooth muscle cell cultures, Oncostatin M was a potent mitogen for cells derived from acquired immunodeficiency syndrome-related Kaposi's sarcoma (AIDS-KS). After exposure to Oncostatin M, AIDS-KS cells assumed a spindle morphology, had an increased ability to proliferate in soft agar, and secreted increased amounts of interleukin-6. Oncostatin M RNA and immunoreactive Oncostatin M protein were found in AIDS-KS-derived cell isolates. These results suggest that Oncostatin M may play a role in the pathogenesis of AIDS-KS.

Links

PubMed

Keywords

Acquired Immunodeficiency Syndrome/complications; Base Sequence; Cell Division/drug effects; Growth Substances/biosynthesis; Growth Substances/physiology; Humans; Molecular Sequence Data; Neoplasm Proteins/biosynthesis; Oncostatin M; Peptide Biosynthesis; Peptides/physiology; Recombinant Proteins/pharmacology; Sarcoma, Kaposi/etiology; Sarcoma, Kaposi/metabolism; Sarcoma, Kaposi/pathology; Tumor Cells, Cultured

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ONCM

involved_in

GO:1902036: regulation of hematopoietic stem cell differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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