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HUMAN:NUCG

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ENDOG
Protein Name(s) Endonuclease G, mitochondrial

Endo G

External Links
UniProt Q14249
EMBL X79444
AL441992
BC004922
BC016351
CCDS CCDS6912.1
PIR T09542
RefSeq NP_004426.2
UniGene Hs.745161
ProteinModelPortal Q14249
SMR Q14249
BioGrid 108336
IntAct Q14249
STRING 9606.ENSP00000361725
ChEMBL CHEMBL3804749
iPTMnet Q14249
PhosphoSitePlus Q14249
BioMuta ENDOG
DMDM 317373579
EPD Q14249
MaxQB Q14249
PaxDb Q14249
PeptideAtlas Q14249
PRIDE Q14249
DNASU 2021
Ensembl ENST00000372642
GeneID 2021
KEGG hsa:2021
UCSC uc004bwc.4
CTD 2021
DisGeNET 2021
EuPathDB HostDB:ENSG00000167136.6
GeneCards ENDOG
H-InvDB HIX0008437
HIX0008438
HGNC HGNC:3346
HPA HPA021335
HPA021830
MIM 600440
neXtProt NX_Q14249
OpenTargets ENSG00000167136
PharmGKB PA27783
eggNOG KOG3721
COG1864
GeneTree ENSGT00530000063772
HOGENOM HOG000214172
HOVERGEN HBG002851
InParanoid Q14249
KO K01173
OMA VPHWVFE
OrthoDB EOG091G0BHG
PhylomeDB Q14249
TreeFam TF105386
SIGNOR Q14249
GeneWiki ENDOG
GenomeRNAi 2021
PMAP-CutDB Q5T281
PRO PR:Q14249
Proteomes UP000005640
Bgee ENSG00000167136
CleanEx HS_ENDOG
ExpressionAtlas Q14249
Genevisible Q14249
GO GO:0005829
GO:0005739
GO:0005634
GO:0043204
GO:0004536
GO:0004519
GO:0046872
GO:0003676
GO:0007568
GO:0006309
GO:0071277
GO:0071333
GO:0071456
GO:0006310
GO:0001701
GO:0036475
GO:1902512
GO:1901300
GO:0046677
GO:0032355
GO:0009612
GO:0034612
InterPro IPR018524
IPR001604
IPR020821
Pfam PF01223
SMART SM00892
SM00477
PROSITE PS01070

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006309

apoptotic DNA fragmentation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261433
PANTHER:PTN000359598
PomBase:SPAC17C9.08
SGD:S000003744
WB:WBGene00000787

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000359598
SGD:S000003744
UniProtKB:Q9Y2C4

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000359598
PomBase:SPAC17C9.08
RGD:1310763
UniProtKB:P38447
UniProtKB:Q5BB95
WB:WBGene00000787

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000359598
RGD:1310763
SGD:S000003744

C

Seeded From UniProt

complete

enables

GO:0004529

exodeoxyribonuclease activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002678234
SGD:S000003744

F

Seeded From UniProt

complete

enables

GO:0004521

endoribonuclease activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033690
PANTHER:PTN002678234
PomBase:SPAC17C9.08
WB:WBGene00000787

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033690
PANTHER:PTN000359704
PomBase:SPAC17C9.08
SGD:S000003744
UniProtKB:Q9Y2C4
WB:WBGene00000787

F

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000359598
WB:WBGene00000787

P

Seeded From UniProt

complete

enables

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002678234
PomBase:SPAC17C9.08

F

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004521

P

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08600
ensembl:ENSMUSP00000015481

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08600
ensembl:ENSMUSP00000015481

P

Seeded From UniProt

complete

involved_in

GO:0034612

response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08600
ensembl:ENSMUSP00000015481

P

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08600
ensembl:ENSMUSP00000015481

P

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08600
ensembl:ENSMUSP00000015481

P

Seeded From UniProt

complete

involved_in

GO:1902512

positive regulation of apoptotic DNA fragmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:1901300

positive regulation of hydrogen peroxide-mediated programmed cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

C

Seeded From UniProt

complete

involved_in

GO:0036475

neuron death in response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

C

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3V5X8
ensembl:ENSRNOP00000021531

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:18309324[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
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