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HUMAN:NU153
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NUP153 | |
| Protein Name(s) | Nuclear pore complex protein Nup153
153 kDa nucleoporin Nucleoporin Nup153 | |
| External Links | ||
| UniProt | P49790 | |
| EMBL | Z25535 AK295644 AB210024 AL138824 AL138724 AL157776 AL157776 AL138724 AL138824 AL138724 AL138824 AL157776 BC052965 | |
| CCDS | CCDS4541.1 CCDS64359.1 CCDS75407.1 | |
| PIR | S42718 | |
| RefSeq | NP_001265138.1 NP_001265139.1 NP_005115.2 | |
| UniGene | Hs.601591 | |
| PDB | 2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D | |
| PDBsum | 2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D | |
| ProteinModelPortal | P49790 | |
| SMR | P49790 | |
| BioGrid | 115297 | |
| DIP | DIP-38185N | |
| IntAct | P49790 | |
| MINT | MINT-121422 | |
| STRING | 9606.ENSP00000262077 | |
| TCDB | 1.I.1.1.3 | |
| iPTMnet | P49790 | |
| PhosphoSitePlus | P49790 | |
| DMDM | 206729891 | |
| EPD | P49790 | |
| MaxQB | P49790 | |
| PaxDb | P49790 | |
| PeptideAtlas | P49790 | |
| PRIDE | P49790 | |
| Ensembl | ENST00000262077 ENST00000537253 ENST00000613258 | |
| GeneID | 9972 | |
| KEGG | hsa:9972 | |
| UCSC | uc003ncd.3 | |
| CTD | 9972 | |
| DisGeNET | 9972 | |
| GeneCards | NUP153 | |
| H-InvDB | HIX0032892 HIX0200901 | |
| HGNC | HGNC:8062 | |
| HPA | HPA027896 HPA027897 HPA027898 | |
| MIM | 603948 | |
| neXtProt | NX_P49790 | |
| OpenTargets | ENSG00000124789 | |
| PharmGKB | PA31848 | |
| eggNOG | KOG4719 ENOG41107SV | |
| GeneTree | ENSGT00700000104544 | |
| HOGENOM | HOG000088610 | |
| HOVERGEN | HBG052679 | |
| InParanoid | P49790 | |
| KO | K14296 | |
| OMA | NFKFGDQ | |
| OrthoDB | EOG091G015X | |
| PhylomeDB | P49790 | |
| TreeFam | TF323517 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-1169408 R-HSA-1169408] [www.reactome.org/content/detail/R-HSA-159227 R-HSA-159227] [www.reactome.org/content/detail/R-HSA-159230 R-HSA-159230] [www.reactome.org/content/detail/R-HSA-159231 R-HSA-159231] [www.reactome.org/content/detail/R-HSA-159236 R-HSA-159236] [www.reactome.org/content/detail/R-HSA-165054 R-HSA-165054] [www.reactome.org/content/detail/R-HSA-168271 R-HSA-168271] [www.reactome.org/content/detail/R-HSA-168276 R-HSA-168276] [www.reactome.org/content/detail/R-HSA-168325 R-HSA-168325] [www.reactome.org/content/detail/R-HSA-168333 R-HSA-168333] [www.reactome.org/content/detail/R-HSA-170822 R-HSA-170822] [www.reactome.org/content/detail/R-HSA-180746 R-HSA-180746] [www.reactome.org/content/detail/R-HSA-180910 R-HSA-180910] [www.reactome.org/content/detail/R-HSA-191859 R-HSA-191859] [www.reactome.org/content/detail/R-HSA-3108214 R-HSA-3108214] [www.reactome.org/content/detail/R-HSA-3301854 R-HSA-3301854] [www.reactome.org/content/detail/R-HSA-3371453 R-HSA-3371453] [www.reactome.org/content/detail/R-HSA-4570464 R-HSA-4570464] [www.reactome.org/content/detail/R-HSA-4615885 R-HSA-4615885] [www.reactome.org/content/detail/R-HSA-5578749 R-HSA-5578749] [www.reactome.org/content/detail/R-HSA-6784531 R-HSA-6784531] | |
| SignaLink | P49790 | |
| SIGNOR | P49790 | |
| ChiTaRS | NUP153 | |
| EvolutionaryTrace | P49790 | |
| GeneWiki | NUP153 | |
| GenomeRNAi | 9972 | |
| PMAP-CutDB | P49790 | |
| PRO | PR:P49790 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000124789 | |
| CleanEx | HS_NUP153 | |
| Genevisible | P49790 | |
| GO | GO:0005829 GO:0042405 GO:0031965 GO:0034399 GO:0005643 GO:0044615 GO:0005730 GO:0005654 GO:0003677 GO:0042802 GO:0008139 GO:0005487 GO:0043495 GO:0017056 GO:0008270 GO:0031047 GO:0075733 GO:0007077 GO:0006406 GO:0046832 GO:0051292 GO:0006606 GO:0016925 GO:1900034 GO:0010827 GO:0006409 GO:0046718 GO:0075732 GO:0016032 GO:0019083 | |
| Gene3D | 4.10.1060.10 | |
| InterPro | IPR026054 IPR013913 IPR018892 IPR001876 | |
| PANTHER | PTHR23193 | |
| Pfam | PF08604 PF10599 PF00641 | |
| SMART | SM00547 | |
| SUPFAM | SSF90209 | |
| PROSITE | PS01358 PS50199 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0051292 |
nuclear pore complex assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051292 |
nuclear pore complex assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046832 |
negative regulation of RNA export from nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044615 |
nuclear pore nuclear basket |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043495 |
protein membrane anchor |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043495 |
protein membrane anchor |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042405 |
nuclear inclusion body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034399 |
nuclear periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034399 |
nuclear periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017056 |
structural constituent of nuclear pore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017056 |
structural constituent of nuclear pore |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044615 |
nuclear pore nuclear basket |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000573960 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044613 |
nuclear pore central transport channel |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0061200 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017056 |
structural constituent of nuclear pore |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0061200 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008139 |
nuclear localization sequence binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000573960 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006606 |
protein import into nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010660 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043657 |
host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0075733 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043657 |
host cell |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0075732 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017056 |
structural constituent of nuclear pore |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0016020 |
membrane |
ECO:0000315 |
C |
To confirm the direct membrane binding of full-length Nup153, we turned to the human ortholog, due to the low expression yield of the Xenopus Nup153. Human Nup153 possesses 42% amino acid identity and 55% similarity with the Xenopus protein. The fluorescently labeled human Nup153 efficiently bound GUVs ( Figure 1G). The corresponding membrane-binding-deficient mutation (V47E in the human protein) abrogated the membrane interaction. |
complete | |||||
|
involved_in |
GO:1900034 |
regulation of cellular response to heat |
Reactome:R-HSA-3371453 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0075733 |
intracellular transport of virus |
Reactome:R-HSA-1176059 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060964 |
regulation of gene silencing by miRNA |
Reactome:R-HSA-5578749 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019083 |
viral transcription |
Reactome:R-HSA-168325 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016925 |
protein sumoylation |
Reactome:R-HSA-4655355 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016032 |
viral process |
Reactome:R-HSA-162599 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006409 |
tRNA export from nucleus |
Reactome:R-HSA-6783483 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
Reactome:R-HSA-75098 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006110 |
regulation of glycolytic process |
Reactome:R-HSA-170822 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-75098 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075732 |
viral penetration into host nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Krull, S et al. (2004) Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Mol. Biol. Cell 15 4261-77 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Hase, ME & Cordes, VC (2003) Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol. Biol. Cell 14 1923-40 PubMed GONUTS page
- ↑ 3.0 3.1 Rajanala, K & Nandicoori, VK (2012) Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. PLoS ONE 7 e29921 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Frosst, P et al. (2002) Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J. Cell Biol. 156 617-30 PubMed GONUTS page
- ↑ Krull, S et al. (2010) Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion. EMBO J. 29 1659-73 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Milles, S et al. (2013) Facilitated aggregation of FG nucleoporins under molecular crowding conditions. EMBO Rep. 14 178-83 PubMed GONUTS page
- ↑ Vollmer, B et al. (2015) Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly. Dev. Cell 33 717-28 PubMed GONUTS page
m
n
- GO:0046832 ! negative regulation of RNA export from nucleus
- GO:0042405 ! nuclear inclusion body
- GO:0008139 ! nuclear localization sequence binding
- GO:0031965 ! nuclear membrane
- GO:0034399 ! nuclear periphery
- GO:0051292 ! nuclear pore complex assembly
- GO:0005643 ! nuclear pore
- GO:0044615 ! nuclear pore nuclear basket
- GO:0044613 ! nuclear pore central transport channel
- GO:0005730 ! nucleolus
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
r
