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HUMAN:NRF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NRF1
Protein Name(s) Nuclear respiratory factor 1

NRF-1 Alpha palindromic-binding protein Alpha-pal

External Links
UniProt Q16656
EMBL L22454
U02683
U18383
U18375
U18376
U18377
U18378
U18379
U18380
U18381
U18382
EU159452
AK290891
AK293351
AC078846
AC084864
CH236950
CH471070
BC016925
CCDS CCDS5813.2
PIR A54868
RefSeq NP_001035199.1
NP_001280092.1
NP_001280093.1
NP_005002.3
UniGene Hs.654363
ProteinModelPortal Q16656
BioGrid 110955
IntAct Q16656
STRING 9606.ENSP00000223190
PhosphoSite Q16656
DMDM 12643732
MaxQB Q16656
PaxDb Q16656
PRIDE Q16656
DNASU 4899
Ensembl ENST00000223190
ENST00000311967
ENST00000353868
ENST00000393230
ENST00000393232
GeneID 4899
KEGG hsa:4899
UCSC uc003voz.3
uc003vpa.3
CTD 4899
GeneCards GC07P129251
HGNC HGNC:7996
HPA HPA029329
MIM 600879
neXtProt NX_Q16656
PharmGKB PA31775
eggNOG NOG80791
GeneTree ENSGT00390000006835
HOGENOM HOG000273898
HOVERGEN HBG003062
InParanoid Q16656
KO K11831
OMA QGNRPVQ
PhylomeDB Q16656
TreeFam TF105308
Reactome REACT_116145
REACT_200608
ChiTaRS NRF1
GeneWiki NRF1
GenomeRNAi 4899
NextBio 18853
PRO PR:Q16656
Proteomes UP000005640
Bgee Q16656
CleanEx HS_NRF1
ExpressionAtlas Q16656
Genevestigator Q16656
GO GO:0005737
GO:0070062
GO:0005654
GO:0000978
GO:0001077
GO:0044255
GO:0006091
GO:0007005
GO:0031100
GO:0045944
GO:0006357
GO:0051602
GO:0032355
GO:0051593
GO:0001666
GO:0032496
GO:0044281
InterPro IPR019526
IPR019525
Pfam PF10492
PF10491

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000979

RNA polymerase II core promoter sequence-specific DNA binding

PMID:23525105[1]

ECO:0000314

direct assay evidence used in manual assertion

F

  • has_input:(ENSEMBL:ENSG00000119912)
  • part_of:(GO:0006357)
  • occurs_at:(SO:0001669)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:23525105[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSG00000119912)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

F

Seeded From UniProt

complete

enables

GO:0001046

core promoter sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19674972[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:7447)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:19674972[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:19674972[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:19674972[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005427
PANTHER:PTN001838773
UniProtKB:Q16656

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005427
PANTHER:PTN001838773
UniProtKB:Q16656
UniProtKB:Q90979

C

Seeded From UniProt

complete

enables

GO:0001046

core promoter sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001838773
UniProtKB:Q90979

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001838773
UniProtKB:Q16656

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039142

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039142

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

F

Seeded From UniProt

complete

enables

GO:0001046

core promoter sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q90979

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:8034649[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006091

generation of precursor metabolites and energy

PMID:7629110[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

Reactome:R-HSA-1592230

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-2466392
Reactome:R-HSA-2466391
Reactome:R-HSA-2466367
Reactome:R-HSA-1592250
Reactome:R-HSA-1592249
Reactome:R-HSA-1592242
Reactome:R-HSA-1592236

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Leal, MC et al. (2013) Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality. J. Biol. Chem. 288 12920-31 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Fu, J et al. (2009) Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1. J. Biol. Chem. 284 27577-86 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Efiok, BJ et al. (1994) A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J. Biol. Chem. 269 18921-30 PubMed GONUTS page
  6. ↑ Gopalakrishnan, L & Scarpulla, RC (1995) Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. J. Biol. Chem. 270 18019-25 PubMed GONUTS page
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