HUMAN:NOS2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NOS2 (synonyms: NOS2A)
Protein Name(s)	Nitric oxide synthase, inducible Hepatocyte NOS HEP-NOS Inducible NO synthase Inducible NOS iNOS NOS type II Peptidyl-cysteine S-nitrosylase NOS2
External Links
UniProt	P35228
EMBL	L24553 L09210 X73029 U05810 U31511 D26525 U20141 AF068236 AB022318 DQ060518 EU332854 BC130283 BC144126 S75615
CCDS	CCDS11223.1
PIR	A49676
RefSeq	NP_000616.3 XP_011523161.1
UniGene	Hs.709191
PDB	1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS
PDBsum	1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS
ProteinModelPortal	P35228
SMR	P35228
BioGrid	110906
DIP	DIP-59359N
IntAct	P35228
STRING	9606.ENSP00000327251
BindingDB	P35228
ChEMBL	CHEMBL2096621
DrugBank	DB01234 DB00997 DB00125 DB00155 DB01110 DB08814
GuidetoPHARMACOLOGY	1250
iPTMnet	P35228
PhosphoSite	P35228
BioMuta	NOS2
DMDM	1352513
PaxDb	P35228
PRIDE	P35228
Ensembl	ENST00000313735 ENST00000621962
GeneID	4843
KEGG	hsa:4843
UCSC	uc002gzu.4
CTD	4843
GeneCards	NOS2
H-InvDB	HIX0027239
HGNC	HGNC:7873
HPA	CAB002014
MalaCards	NOS2
MIM	163730 611162
neXtProt	NX_P35228
PharmGKB	PA164724093
eggNOG	KOG1158 COG0369 COG4362
GeneTree	ENSGT00620000087711
HOVERGEN	HBG000159
InParanoid	P35228
KO	K13241
OMA	KFTNSPT
OrthoDB	EOG79SDW7
PhylomeDB	P35228
TreeFam	TF324410
BioCyc	MetaCyc:HS00205-MONOMER
BRENDA	1.14.13.39
Reactome	R-HSA-1222556 R-HSA-392154
SignaLink	P35228
ChiTaRS	NOS2
EvolutionaryTrace	P35228
GeneWiki	Nitric_oxide_synthase_2_(inducible)
GenomeRNAi	4843
NextBio	18662
PRO	PR:P35228
Proteomes	UP000005640
Bgee	P35228
CleanEx	HS_NOS2
Genevisible	P35228
GO	GO:0030863 GO:0005737 GO:0005829 GO:0005622 GO:0005634 GO:0048471 GO:0005777 GO:0034618 GO:0050660 GO:0010181 GO:0020037 GO:0005506 GO:0050661 GO:0004517 GO:0042803 GO:0005102 GO:0034617 GO:0006527 GO:0007596 GO:0045454 GO:0035690 GO:0071346 GO:0071222 GO:0007623 GO:0042742 GO:0050829 GO:0006954 GO:0002227 GO:0072604 GO:0072606 GO:0045776 GO:0010629 GO:0042177 GO:0006809 GO:0007263 GO:0018119 GO:0031284 GO:0051712 GO:0001912 GO:0045909 GO:0032310 GO:0042127 GO:0043457 GO:1900015 GO:0050796 GO:0009617 GO:0001666 GO:0006801
Gene3D	1.20.990.10 3.40.50.360 3.90.340.10
InterPro	IPR003097 IPR017927 IPR001094 IPR008254 IPR001709 IPR029039 IPR023173 IPR004030 IPR001433 IPR017938
Pfam	PF00667 PF00258 PF00175 PF02898
PRINTS	PR00369 PR00371
SUPFAM	SSF52218 SSF56512 SSF63380
PROSITE	PS51384 PS50902 PS60001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009055	electron carrier activity	other:GO_REF:0000100	ECO:0000247		PMID:2334437^[1]	F		The transfer annotation HHpred hits had an E-value of 6.4E-27, a similarity of 100%, and a query coverage of 78.26% which serves as the evidence.	complete CACAO 12050
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	PMID:19688109^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	PMID:19688109^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032310	prostaglandin secretion	PMID:19688109^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072604	interleukin-6 secretion	PMID:19688109^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051712	positive regulation of killing of cells of other organism	PMID:7544003^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:18390757^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:8383325^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:9284131^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034618	arginine binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
enables	GO:0034617	tetrahydrobiopterin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:7504305^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:7504305^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7504305^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9916929^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06518	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:7504305^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:18390757^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	P		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:12085352^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P29477	P	has_regulation_target:(UniProtKB:P24270)	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:12085352^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:7682706^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:12085352^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12085352^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20178365^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50542	F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:7682706^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453988 RGD:3184	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN000453992 UniProtKB:P35228	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 ZFIN:ZDB-GENE-040305-1	P		Seeded From UniProt	complete
involved_in	GO:0031284	positive regulation of guanylate cyclase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 UniProtKB:P29473 UniProtKB:P29474	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97744 PANTHER:PTN000453956 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002322100 RGD:3185	P		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 ZFIN:ZDB-GENE-001101-1	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3186 UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453956 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228 UniProtKB:Q9SB48 UniProtKB:Q9UHB4	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453765 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011676 MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P29475 UniProtKB:P35228	F		Seeded From UniProt	complete
enables	GO:0003958	NADPH-hemoprotein reductase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453763 PomBase:SPBC29A10.01 RGD:68335 SGD:S000001084 TAIR:locus:2128951 UniProtKB:A0A1D8PLR7 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:P16435 UniProtKB:Q9UBK8	F		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
enables	GO:0034618	arginine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
enables	GO:0034617	tetrahydrobiopterin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
part_of	GO:0030863	cortical cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	C		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29477 ensembl:ENSMUSP00000018610	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR008254 InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR017927 InterPro:IPR023173	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR004030 InterPro:IPR017927 InterPro:IPR023173 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.13.39	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:7504305^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043457	regulation of cellular respiration	PMID:10450191^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	PMID:10450191^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	Reactome:R-HSA-1222556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006625	protein targeting to peroxisome	Reactome:R-HSA-9033241	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9033236 Reactome:R-HSA-9033235 Reactome:R-HSA-6790041 Reactome:R-HSA-418436	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	Reactome:R-HSA-9033235	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

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↑ Helms, LR et al. (1990) Identification, sequence determination, and expression of the flavodoxin gene from Desulfovibrio salexigens. Biochem. Biophys. Res. Commun. 168 809-17 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Vuolteenaho, K et al. (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009 345838 PubMed GONUTS page
↑ Vouldoukis, I et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc. Natl. Acad. Sci. U.S.A. 92 7804-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Vareille, M et al. (2008) Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes. J. Immunol. 180 5720-6 PubMed GONUTS page
↑ Corbett, JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. U.S.A. 90 1731-5 PubMed GONUTS page
↑ Nozaki, Y et al. (1997) Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. Infect. Immun. 65 3644-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Charles, IG et al. (1993) Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. U.S.A. 90 11419-23 PubMed GONUTS page
↑ Facchetti, F et al. (1999) Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. Am. J. Pathol. 154 145-52 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Stolz, DB et al. (2002) Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology 36 81-93 PubMed GONUTS page
↑ ^10.0 ^10.1 Geller, DA et al. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 90 3491-5 PubMed GONUTS page
↑ Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Moncada, S (1999) Nitric oxide: discovery and impact on clinical medicine. J R Soc Med 92 164-9 PubMed GONUTS page

[PMID:2334437-1] Helms, LR et al. (1990) Identification, sequence determination, and expression of the flavodoxin gene from Desulfovibrio salexigens. Biochem. Biophys. Res. Commun. 168 809-17 PubMed GONUTS page

[PMID:19688109-2] 2.0 ^2.1 ^2.2 ^2.3 Vuolteenaho, K et al. (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009 345838 PubMed GONUTS page

[PMID:7544003-3] Vouldoukis, I et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc. Natl. Acad. Sci. U.S.A. 92 7804-8 PubMed GONUTS page

[PMID:18390757-4] 4.0 ^4.1 Vareille, M et al. (2008) Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes. J. Immunol. 180 5720-6 PubMed GONUTS page

[PMID:8383325-5] Corbett, JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. U.S.A. 90 1731-5 PubMed GONUTS page

[PMID:9284131-6] Nozaki, Y et al. (1997) Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. Infect. Immun. 65 3644-7 PubMed GONUTS page

[PMID:7504305-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Charles, IG et al. (1993) Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. U.S.A. 90 11419-23 PubMed GONUTS page

[PMID:9916929-8] Facchetti, F et al. (1999) Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. Am. J. Pathol. 154 145-52 PubMed GONUTS page

[PMID:12085352-9] 9.0 ^9.1 ^9.2 ^9.3 Stolz, DB et al. (2002) Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology 36 81-93 PubMed GONUTS page

[PMID:7682706-10] 10.0 ^10.1 Geller, DA et al. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 90 3491-5 PubMed GONUTS page

[PMID:20178365-11] Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10450191-13] 13.0 ^13.1 Moncada, S (1999) Nitric oxide: discovery and impact on clinical medicine. J R Soc Med 92 164-9 PubMed GONUTS page

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