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HUMAN:NLRC3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NLRC3 (synonyms: NOD3) | |
| Protein Name(s) | Protein NLRC3
CARD15-like protein Caterpiller protein 16.2 CLR16.2 Nucleotide-binding oligomerization domain protein 3 | |
| External Links | ||
| UniProt | Q7RTR2 | |
| EMBL | BK001112 AY601811 AK090431 AK074109 AF501291 AF501292 | |
| CCDS | CCDS73817.1 | |
| RefSeq | NP_849172.2 | |
| UniGene | Hs.592091 Hs.741496 | |
| ProteinModelPortal | Q7RTR2 | |
| SMR | Q7RTR2 | |
| BioGrid | 128254 | |
| IntAct | Q7RTR2 | |
| STRING | 9606.ENSP00000414415 | |
| PhosphoSite | Q7RTR2 | |
| MaxQB | Q7RTR2 | |
| PaxDb | Q7RTR2 | |
| PRIDE | Q7RTR2 | |
| Ensembl | ENST00000359128 ENST00000448023 ENST00000615877 | |
| GeneID | 197358 | |
| KEGG | hsa:197358 | |
| UCSC | uc010btn.3 | |
| CTD | 197358 | |
| GeneCards | GC16M003592 | |
| HGNC | HGNC:29889 | |
| neXtProt | NX_Q7RTR2 | |
| PharmGKB | PA162397626 | |
| eggNOG | NOG69209 | |
| GeneTree | ENSGT00770000120460 | |
| HOGENOM | HOG000108875 | |
| HOVERGEN | HBG055285 | |
| InParanoid | Q7RTR2 | |
| PhylomeDB | Q7RTR2 | |
| ChiTaRS | NLRC3 | |
| GeneWiki | NLRC3 | |
| GenomeRNAi | 197358 | |
| NextBio | 89661 | |
| PRO | PR:Q7RTR2 | |
| Proteomes | UP000005640 | |
| Bgee | Q7RTR2 | |
| CleanEx | HS_NLRC3 | |
| ExpressionAtlas | Q7RTR2 | |
| Genevestigator | Q7RTR2 | |
| GO | GO:0005737 GO:0005524 GO:0007249 GO:0043124 GO:0032088 GO:0031396 GO:0032496 GO:0042110 | |
| InterPro | IPR007111 | |
| PROSITE | PS50837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000314 |
P |
Overexpression of NLRC3 led to decreased production of TNF through the MyD88 pathway of Hek293 T cells as shown in figure 1b. |
complete | |||||
| GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000314 |
P |
Figure 1d the second graph indicate that with overexpressed NLRC3 this decreases production of IL-6 in HEK293 t cells. |
complete | |||||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
P |
Figure 1c shows when NLRC3 is not expressed in HEK293 T cells then the production of TNF in these cells increases indicating that NLRC3 negatively regulates TNF production. |
complete | |||||
| GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
P |
Figure 1c shows that when NLRC3 is not expressed concentrations of IL-6 increase indicating that NLRC3 negatively regulates IL-6 production in HEK293 T cells. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900016 |
negative regulation of cytokine production involved in inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045824 |
negative regulation of innate immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032687 |
negative regulation of interferon-alpha production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036312 |
phosphatidylinositol 3-kinase regulatory subunit binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042110 |
T cell activation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444070 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001946600 |
C |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page
- ↑ 2.0 2.1 Zhang, L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40 329-41 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gültekin, Y et al. (2015) Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein. J Innate Immun 7 25-36 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Conti, BJ et al. (2005) CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem. 280 18375-85 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
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- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:1900016 ! negative regulation of cytokine production involved in inflammatory response
- GO:0045824 ! negative regulation of innate immune response
- GO:0032688 ! negative regulation of interferon-beta production
- GO:0032687 ! negative regulation of interferon-alpha production
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:0048147 ! negative regulation of fibroblast proliferation
- GO:1901223 ! negative regulation of non-canonical NF-kappaB signal transduction
- GO:0050728 ! negative regulation of inflammatory response
- GO:1900226 ! negative regulation of NLRP3 inflammasome complex assembly
- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0043124 ! negative regulation of canonical NF-kappaB signal transduction
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0000166 ! nucleotide binding
p
