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HUMAN:NK3R

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TACR3 (synonyms: NK3R, TAC3R)
Protein Name(s) Neuromedin-K receptor

NKR NK-3 receptor NK-3R Neurokinin B receptor Tachykinin receptor 3

External Links
UniProt P29371
EMBL M89473
S86392
S86371
S86382
S86388
S86390
X65172
X65173
X65174
X65175
X65176
AY462099
BC121806
CCDS CCDS3664.1
PIR JQ1517
RefSeq NP_001050.1
UniGene Hs.942
ProteinModelPortal P29371
SMR P29371
BioGrid 112733
IntAct P29371
STRING 9606.ENSP00000303325
BindingDB P29371
ChEMBL CHEMBL4429
GuidetoPHARMACOLOGY 362
PhosphoSite P29371
BioMuta TACR3
DMDM 128364
PaxDb P29371
PRIDE P29371
Ensembl ENST00000304883
GeneID 6870
KEGG hsa:6870
UCSC uc003hxe.1
CTD 6870
GeneCards TACR3
GeneReviews TACR3
HGNC HGNC:11528
HPA HPA009418
MIM 162332
614840
neXtProt NX_P29371
Orphanet 478
432
PharmGKB PA36304
eggNOG NOG331485
GeneTree ENSGT00760000118781
HOGENOM HOG000013018
HOVERGEN HBG103412
InParanoid P29371
KO K04224
OMA FTYHVIV
OrthoDB EOG7N37FW
PhylomeDB P29371
TreeFam TF315303
Reactome R-HSA-380095
R-HSA-416476
GeneWiki Tachykinin_receptor_3
GenomeRNAi 6870
NextBio 26817
PRO PR:P29371
Proteomes UP000005640
Bgee P29371
CleanEx HS_TACR3
Genevisible P29371
GO GO:0005737
GO:0032590
GO:0005887
GO:0032809
GO:0005634
GO:0005886
GO:0004995
GO:0007568
GO:0042538
GO:0045777
GO:0010460
GO:0070474
GO:0042053
GO:0060259
GO:0042220
GO:0032355
GO:0043278
GO:0007217
InterPro IPR000276
IPR017452
IPR001681
IPR001013
Pfam PF00001
PRINTS PR00237
PR01026
PR00244
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0097225

sperm midpiece

PMID:17437961[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1902093

positive regulation of flagellated sperm motility

PMID:17437961[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902093

positive regulation of flagellated sperm motility

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002538240
UniProtKB:P21452
UniProtKB:P25103
UniProtKB:P29371

P

Seeded From UniProt

complete

part_of

GO:0097225

sperm midpiece

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002538240
UniProtKB:P21452
UniProtKB:P25103
UniProtKB:P29371

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001544873
RGD:3810
RGD:3811
UniProtKB:P21452
UniProtKB:P25103

C

Seeded From UniProt

complete

enables

GO:0004995

tachykinin receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001544873
RGD:3810
RGD:3811
RGD:3812
UniProtKB:P25103
ZFIN:ZDB-GENE-061207-19
ZFIN:ZDB-GENE-090312-106

F

Seeded From UniProt

complete

involved_in

GO:0070474

positive regulation of uterine smooth muscle contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0060259

regulation of feeding behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0043278

response to morphine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0042538

hyperosmotic salinity response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0042053

regulation of dopamine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

part_of

GO:0032809

neuronal cell body membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

C

Seeded From UniProt

complete

part_of

GO:0032590

dendrite membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

C

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

C

Seeded From UniProt

complete

involved_in

GO:0010460

positive regulation of heart rate

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

C

Seeded From UniProt

complete

enables

GO:0004995

tachykinin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16177
ensembl:ENSRNOP00000012473

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004995

tachykinin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001013
InterPro:IPR001681

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001013
InterPro:IPR001681

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001013
InterPro:IPR001681

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001013
InterPro:IPR001681
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0007217

tachykinin receptor signaling pathway

PMID:8990205[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:1374246[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004995

tachykinin receptor activity

PMID:8990205[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-383373
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Ravina, CG et al. (2007) A role for tachykinins in the regulation of human sperm motility. Hum. Reprod. 22 1617-25 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Krause, JE et al. (1997) Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. Proc. Natl. Acad. Sci. U.S.A. 94 310-5 PubMed GONUTS page
  4. ↑ Huang, RR et al. (1992) cDNA sequence and heterologous expression of the human neurokinin-3 receptor. Biochem. Biophys. Res. Commun. 184 966-72 PubMed GONUTS page
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