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HUMAN:NGLY1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NGLY1 (synonyms: PNG1)
Protein Name(s) Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

PNGase hPNGase N-glycanase 1 Peptide:N-glycanase

External Links
UniProt Q96IV0
EMBL AF250924
AK296047
AB209549
AC092798
BC000963
BC007226
BC017220
CCDS CCDS33719.1
CCDS46777.1
CCDS46778.1
CCDS46779.1
RefSeq NP_001138765.1
NP_001138766.1
NP_001138767.1
NP_060767.2
UniGene Hs.368960
PDB 2CCQ
2CM0
PDBsum 2CCQ
2CM0
ProteinModelPortal Q96IV0
SMR Q96IV0
BioGrid 120885
IntAct Q96IV0
MINT MINT-3054125
STRING 9606.ENSP00000280700
PhosphoSite Q96IV0
DMDM 74732105
MaxQB Q96IV0
PaxDb Q96IV0
PRIDE Q96IV0
DNASU 55768
Ensembl ENST00000280700
ENST00000308710
ENST00000396649
ENST00000417874
ENST00000428257
GeneID 55768
KEGG hsa:55768
UCSC uc003cdl.3
uc003cdm.3
uc010hfg.3
uc011awo.2
CTD 55768
GeneCards GC03M025735
HGNC HGNC:17646
HPA HPA036825
MIM 610661
615273
neXtProt NX_Q96IV0
Orphanet 404454
PharmGKB PA38462
eggNOG NOG307426
GeneTree ENSGT00390000006540
HOGENOM HOG000247069
HOVERGEN HBG082026
InParanoid Q96IV0
KO K01456
OMA CQNTPET
OrthoDB EOG780RMR
PhylomeDB Q96IV0
TreeFam TF315254
ChiTaRS NGLY1
EvolutionaryTrace Q96IV0
GeneWiki NGLY1
GenomeRNAi 55768
NextBio 60817
PRO PR:Q96IV0
Proteomes UP000005640
Bgee Q96IV0
CleanEx HS_NGLY1
ExpressionAtlas Q96IV0
Genevestigator Q96IV0
GO GO:0005737
GO:0046872
GO:0000224
GO:0006516
InterPro IPR008979
IPR006588
IPR018997
IPR006567
IPR002931
Pfam PF04721
PF09409
PF01841
SMART SM00613
SM00580
SM00460
SUPFAM SSF49785
PROSITE PS51398

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006516

glycoprotein catabolic process

PMID:15358861[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15358861[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006517

protein deglycosylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033050
PANTHER:PTN000254236
SGD:S000006017
UniProtKB:Q96IV0
WB:WBGene00010160

P

Seeded From UniProt

complete

involved_in

GO:0006516

glycoprotein catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913276
PANTHER:PTN000254236
UniProtKB:Q96IV0

P

Seeded From UniProt

complete

involved_in

GO:0006515

protein quality control for misfolded or incompletely synthesized proteins

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000254236
SGD:S000006017

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033050
PANTHER:PTN000254236
SGD:S000006017
TAIR:locus:2157869
dictyBase:DDB_G0268168

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000254236
SGD:S000006017
dictyBase:DDB_G0268168

C

Seeded From UniProt

complete

enables

GO:0000224

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033050
PANTHER:PTN000254236
PomBase:SPBC1709.14
SGD:S000006017
TAIR:locus:2157869
UniProtKB:Q96IV0
WB:WBGene00010160
dictyBase:DDB_G0268168

F

Seeded From UniProt

complete

enables

GO:0000224

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

PMID:28826503[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q02890

F

Seeded From UniProt

complete

involved_in

GO:0006517

protein deglycosylation

PMID:28826503[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006517

protein deglycosylation

PMID:28826503[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q02890

P

Seeded From UniProt

complete

involved_in

GO:0006516

glycoprotein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI78
ensembl:ENSMUSP00000022310

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JI78
ensembl:ENSMUSP00000022310

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006588

C

Seeded From UniProt

complete

involved_in

GO:0006516

glycoprotein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006588

P

Seeded From UniProt

complete

enables

GO:0000224

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.52

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

Reactome:R-HSA-532668

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8850594

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000224

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

Reactome:R-HSA-8850594

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Katiyar, S et al. (2004) A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 101 13774-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Galeone, A et al. (2017) Tissue-specific regulation of BMP signaling by -glycanase 1. Elife 6 PubMed GONUTS page
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