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HUMAN:NEXN

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NEXN (ECO:0000312 with HGNC:HGNC:29557)
Protein Name(s) Nexilin

F-actin-binding protein Nelin

External Links
UniProt Q0ZGT2
EMBL DQ464902
AK057954
AK298565
AC096948
AC138392
BC055084
BC017827
BC111395
BC114444
BC114445
AF114264
S67069
CCDS CCDS41351.1
CCDS53335.1
RefSeq NP_001165780.1
NP_653174.3
XP_005271380.1
UniGene Hs.612385
ProteinModelPortal Q0ZGT2
SMR Q0ZGT2
BioGrid 124855
IntAct Q0ZGT2
MINT MINT-8187852
PhosphoSite Q0ZGT2
DMDM 121945484
MaxQB Q0ZGT2
PaxDb Q0ZGT2
PRIDE Q0ZGT2
Ensembl ENST00000330010
ENST00000334785
GeneID 91624
KEGG hsa:91624
UCSC uc001dia.3
uc001dib.4
uc001dic.4
CTD 91624
GeneCards GC01P078354
GeneReviews NEXN
HGNC HGNC:29557
HPA HPA011185
MIM 613121
613122
613876
neXtProt NX_Q0ZGT2
Orphanet 154
155
PharmGKB PA134974801
eggNOG NOG147699
GeneTree ENSGT00730000111176
HOVERGEN HBG066529
InParanoid Q0ZGT2
OMA NFHEEED
OrthoDB EOG7TBC1Z
PhylomeDB Q0ZGT2
TreeFam TF328960
ChiTaRS NEXN
GenomeRNAi 91624
NextBio 77345
PRO PR:Q0ZGT2
Proteomes UP000005640
Bgee Q0ZGT2
CleanEx HS_NEXN
ExpressionAtlas Q0ZGT2
Genevestigator Q0ZGT2
GO GO:0005856
GO:0005925
GO:0030018
GO:0051015
GO:0004683
GO:0008307
GO:0048739
GO:0006468
GO:0030334
GO:0051493
Gene3D 2.60.40.10
InterPro IPR007110
IPR013783
IPR013098
IPR003599
IPR020675
PANTHER PTHR22964
Pfam PF07679
SMART SM00409
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005925

focal adhesion

PMID:21423176[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

involved_in

GO:0051493

regulation of cytoskeleton organization

PMID:15823560[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:15823560[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030334

regulation of cell migration

PMID:15823560[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2J4

C

Seeded From UniProt

complete

enables

GO:0008307

structural constituent of muscle

PMID:19881492[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0098632

cell-cell adhesion mediator activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010473
FB:FBgn0028482
PANTHER:PTN001296633

F

Seeded From UniProt

complete

involved_in

GO:0070593

dendrite self-avoidance

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010473
MGI:MGI:1196281
MGI:MGI:2150309
PANTHER:PTN001296633
UniProtKB:A0A0B4K823

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104750
MGI:MGI:1196281
PANTHER:PTN001296633
RGD:2322545
UniProtKB:A0A0B4K823
UniProtKB:Q03696
WB:WBGene00004370
WB:WBGene00016354

C

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010473
MGI:MGI:104750
PANTHER:PTN001296633
UniProtKB:A0A0B4K823

P

Seeded From UniProt

complete

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000635
FB:FBgn0028482
FB:FBgn0265296
PANTHER:PTN001296633
RGD:620296
UniProtKB:Q8TD84

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000635
MGI:MGI:104750
MGI:MGI:1196281
MGI:MGI:1858223
MGI:MGI:2444710
PANTHER:PTN001296633
UniProtKB:P35613
UniProtKB:Q8WX93

C

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPW1
ensembl:ENSMUSP00000037120

P

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005912

adherens junction

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0009

C

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0314

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Wang, W et al. (2005) NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion. Biochem. Biophys. Res. Commun. 330 1127-31 PubMed GONUTS page
  3. ↑ Hassel, D et al. (2009) Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat. Med. 15 1281-8 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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