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HUMAN:NELFE

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NELFE (synonyms: RD, RDBP)
Protein Name(s) Negative elongation factor E

NELF-E RNA-binding protein RD

External Links
UniProt P18615
EMBL M33231
M32274
M32275
M32276
M33230
L03411
AF019413
AK300717
AK302652
AL049547
AL662849
AL844853
BX005143
CR759782
CR388219
CR753845
AL645922
CR753845
CR388219
CH471081
BC025235
BC050617
X16105
CCDS CCDS4730.1
PIR S36789
RefSeq NP_002895.3
UniGene Hs.423935
PDB 1X5P
2BZ2
2JX2
PDBsum 1X5P
2BZ2
2JX2
ProteinModelPortal P18615
SMR P18615
BioGrid 113662
DIP DIP-32669N
IntAct P18615
MINT MINT-1033320
STRING 9606.ENSP00000388779
PhosphoSite P18615
DMDM 1350554
MaxQB P18615
PaxDb P18615
PRIDE P18615
DNASU 7936
Ensembl ENST00000375425
ENST00000375429
ENST00000383174
ENST00000383343
ENST00000429857
ENST00000444811
ENST00000448628
ENST00000457397
GeneID 7936
KEGG hsa:7936
UCSC uc003nyk.3
uc011dot.2
CTD 7936
GeneCards GC06M031926
GC06Mj31907
GC06Mk31902
GC06Mm31996
GC06Mn31910
GC06Mo31911
HGNC HGNC:13974
HPA HPA007187
MIM 154040
neXtProt NX_P18615
PharmGKB PA134974984
eggNOG NOG86140
GeneTree ENSGT00630000089917
HOGENOM HOG000232089
HOVERGEN HBG052598
InParanoid P18615
KO K15182
OMA YNDDVYK
PhylomeDB P18615
TreeFam TF324087
Reactome REACT_22107
REACT_22201
REACT_6143
REACT_6162
REACT_6244
REACT_6259
REACT_6261
REACT_6319
REACT_6344
REACT_6346
REACT_833
REACT_846
EvolutionaryTrace P18615
GeneWiki RDBP
GenomeRNAi 7936
NextBio 30439
PRO PR:P18615
Proteomes UP000005640
UP000005640
Bgee P18615
CleanEx HS_RDBP
ExpressionAtlas P18615
Genevestigator P18615
GO GO:0032021
GO:0005654
GO:0005634
GO:0000166
GO:0044822
GO:0003723
GO:0010467
GO:0034244
GO:0050434
GO:0006368
GO:0006366
GO:0016032
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900364

negative regulation of mRNA polyadenylation

PMID:19575011[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(ENSEMBL:ENSG00000158373)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032021

NELF complex

PMID:12612062[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2119325[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:2119325[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19426
ensembl:ENSMUSP00000094956

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

P

Seeded From UniProt

complete

involved_in

GO:0051571

positive regulation of histone H3-K4 methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG75
ensembl:ENSRNOP00000000478

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033102

P

Seeded From UniProt

complete

part_of

GO:0032021

NELF complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033102

C

Seeded From UniProt

complete

involved_in

GO:0050434

positive regulation of viral transcription

Reactome:R-HSA-167246

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

Reactome:R-HSA-75955
Reactome:R-HSA-113418
Reactome:R-HSA-112382

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

Reactome:R-HSA-73857

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6797616
Reactome:R-HSA-6797606
Reactome:R-HSA-170706
Reactome:R-HSA-170704
Reactome:R-HSA-113429
Reactome:R-HSA-113414
Reactome:R-HSA-113413
Reactome:R-HSA-113412
Reactome:R-HSA-113411
Reactome:R-HSA-113409
Reactome:R-HSA-113402
Reactome:R-HSA-112437
Reactome:R-HSA-112396
Reactome:R-HSA-112395
Reactome:R-HSA-112392
Reactome:R-HSA-112385
Reactome:R-HSA-112381
Reactome:R-HSA-112379

ECO:0000304

author statement supported by traceable reference used in manual assertion


















C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Pirngruber, J et al. (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep. 10 894-900 PubMed GONUTS page
  2. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  3. ↑ Narita, T et al. (2003) Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell. Biol. 23 1863-73 PubMed GONUTS page
  4. ↑ 4.0 4.1 Surowy, CS et al. (1990) The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved. Gene 90 299-302 PubMed GONUTS page
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