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HUMAN:NEK11

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NEK11 (ECO:0000312 with HGNC:HGNC:18593)
Protein Name(s) Serine/threonine-protein kinase Nek11

Never in mitosis A-related kinase 11 NimA-related protein kinase 11

External Links
UniProt Q8NG66
EMBL AB071996
AB071997
AL833472
AC055733
CH471052
BC028587
AK027148
CCDS CCDS3069.1
CCDS46915.1
CCDS54639.1
RefSeq NP_001139475.1
NP_079076.3
NP_665917.1
XP_005247840.1
XP_006713813.1
UniGene Hs.657336
ProteinModelPortal Q8NG66
SMR Q8NG66
BioGrid 122947
IntAct Q8NG66
STRING 9606.ENSP00000372857
BindingDB Q8NG66
ChEMBL CHEMBL5638
DrugBank DB08912
GuidetoPHARMACOLOGY 2116
PhosphoSite Q8NG66
DMDM 313104142
PaxDb Q8NG66
PRIDE Q8NG66
DNASU 79858
Ensembl ENST00000356918
ENST00000383366
ENST00000507910
ENST00000508196
ENST00000510688
ENST00000511262
GeneID 79858
KEGG hsa:79858
UCSC uc003enx.3
uc003eny.3
uc003eoa.3
uc011blm.2
CTD 79858
GeneCards GC03P130745
HGNC HGNC:18593
HPA HPA016908
MIM 609779
neXtProt NX_Q8NG66
PharmGKB PA38595
eggNOG COG0515
GeneTree ENSGT00760000118997
HOGENOM HOG000293260
HOVERGEN HBG082016
InParanoid Q8NG66
KO K08857
OrthoDB EOG7WMCJ7
PhylomeDB Q8NG66
TreeFam TF106472
SignaLink Q8NG66
ChiTaRS NEK11
GenomeRNAi 79858
NextBio 69585
PRO PR:Q8NG66
Proteomes UP000005640
Bgee Q8NG66
CleanEx HS_NEK11
ExpressionAtlas Q8NG66
Genevestigator Q8NG66
GO GO:0005730
GO:0005634
GO:0005524
GO:0046872
GO:0004674
GO:0031572
GO:0031573
GO:0035556
GO:0006468
InterPro IPR011009
IPR000719
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016572

histone phosphorylation

PMID:12154088[1]

ECO:0000315

P

Figure 2B.

complete
CACAO 6103

GO:1901990

regulation of mitotic cell cycle phase transition

PMID:12154088[1]

ECO:0000315

P

Figure 6.

complete
CACAO 6105

involved_in

GO:0044772

mitotic cell cycle phase transition

PMID:12154088[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

PMID:12154088[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016572

histone phosphorylation

PMID:12154088[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:19734889[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19734889[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15161910[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000757812
UniProtKB:Q8NG66

P

Seeded From UniProt

complete

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000757812
UniProtKB:Q8NG66

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000757812
UniProtKB:Q8NG66

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029970
PANTHER:PTN002462863
UniProtKB:P11837
UniProtKB:P9WI63
UniProtKB:Q8NG66
dictyBase:DDB_G0270814

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Noguchi, K et al. (2002) Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. J. Biol. Chem. 277 39655-65 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Noguchi, K et al. (2004) Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. J. Biol. Chem. 279 32716-27 PubMed GONUTS page
  3. ↑ 3.0 3.1 Melixetian, M et al. (2009) NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat. Cell Biol. 11 1247-53 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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