GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:NEK1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NEK1 (synonyms: KIAA1901)
Protein Name(s) Serine/threonine-protein kinase Nek1

Never in mitosis A-related kinase 1 NimA-related protein kinase 1 Renal carcinoma antigen NY-REN-55

External Links
UniProt Q96PY6
EMBL AB067488
CR933642
AC116615
AC116621
AC084724
CH471056
BC015147
BC037790
BC114491
AK025658
AK027580
AF155113
CCDS CCDS47162.1
CCDS56348.1
CCDS56349.1
CCDS56350.1
CCDS56351.1
RefSeq NP_001186326.1
NP_001186327.1
NP_001186328.1
NP_001186329.1
NP_036356.1
UniGene Hs.481181
PDB 4APC
4B9D
PDBsum 4APC
4B9D
ProteinModelPortal Q96PY6
SMR Q96PY6
BioGrid 110825
IntAct Q96PY6
STRING 9606.ENSP00000408020
BindingDB Q96PY6
ChEMBL CHEMBL5855
GuidetoPHARMACOLOGY 2114
PhosphoSite Q96PY6
DMDM 22256934
MaxQB Q96PY6
PaxDb Q96PY6
PRIDE Q96PY6
Ensembl ENST00000439128
ENST00000507142
ENST00000510533
ENST00000511633
ENST00000512193
GeneID 4750
KEGG hsa:4750
UCSC uc003isb.2
uc003isc.2
uc003isd.2
uc003ise.2
uc003isf.2
uc003isg.1
CTD 4750
GeneCards GC04M170314
HGNC HGNC:7744
HPA HPA020873
HPA040413
MIM 263520
604588
neXtProt NX_Q96PY6
Orphanet 93269
PharmGKB PA31545
eggNOG COG0515
GeneTree ENSGT00760000118997
HOVERGEN HBG006460
InParanoid Q96PY6
KO K08857
OMA KHKQAHQ
OrthoDB EOG7D59P5
PhylomeDB Q96PY6
TreeFam TF333575
SignaLink Q96PY6
ChiTaRS NEK1
GeneWiki NEK1
GenomeRNAi 4750
NextBio 18306
PRO PR:Q96PY6
Proteomes UP000005640
Bgee Q96PY6
CleanEx HS_NEK1
ExpressionAtlas Q96PY6
Genevestigator Q96PY6
GO GO:0005813
GO:0005737
GO:0005634
GO:0000242
GO:0005524
GO:0046872
GO:0004672
GO:0004674
GO:0004713
GO:0006974
GO:0042384
GO:0007067
GO:0010212
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006468

protein phosphorylation

PMID:19158487[1]

ECO:0000314

P

Figure 2A.

complete
CACAO 6106

GO:0016301

kinase activity

PMID:19158487[1]

ECO:0000315

F

Figure 3.

complete
CACAO 6109

involved_in

GO:0042769

DNA damage response, detection of DNA damage

PMID:15604234[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0071889

14-3-3 protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P51954

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

PMID:19158487[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:19158487[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:21211617[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000242

pericentriolar material

PMID:21211617[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919399
PANTHER:PTN000684825
RGD:727905
UniProtKB:Q7RTN6
UniProtKB:Q9C0K7

P

Seeded From UniProt

complete

involved_in

GO:0031098

stress-activated protein kinase signaling cascade

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
UniProtKB:A0A1D8PKE2
UniProtKB:A0A1D8PM87

P

Seeded From UniProt

complete

involved_in

GO:0023014

signal transduction by protein phosphorylation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
TAIR:locus:2205523
UniProtKB:Q9UEW8

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97303
PANTHER:PTN002390813

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0267698
MGI:MGI:1339975
MGI:MGI:1344404
MGI:MGI:1346867
MGI:MGI:1346875
MGI:MGI:1891638
MGI:MGI:1928487
MGI:MGI:1929004
PANTHER:PTN000684825
PomBase:SPAC1F3.02c
PomBase:SPBC17F3.02
PomBase:SPBC1D7.05
PomBase:SPBC409.07c
PomBase:SPBC543.07
RGD:3780
RGD:620966
RGD:621643
SGD:S000000999
SGD:S000002318
SGD:S000002931
SGD:S000003664
SGD:S000004354
SGD:S000005757
SGD:S000006061
TAIR:locus:2017662
TAIR:locus:2074835
TAIR:locus:2087130
TAIR:locus:2170578
UniProtKB:A0A0B4KGS4
UniProtKB:O00506
UniProtKB:O95819
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q57Y61
UniProtKB:Q7RTN6
UniProtKB:Q8N4C8
UniProtKB:Q96PY6
UniProtKB:Q9C0K7
UniProtKB:Q9H2G2
UniProtKB:Q9P289
UniProtKB:Q9S7U9
UniProtKB:Q9UKE5
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
UniProtKB:Q9Y6R4
WB:WBGene00002177
WB:WBGene00002201
WB:WBGene00003368
WB:WBGene00013355
dictyBase:DDB_G0284181
dictyBase:DDB_G0286359

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0031030
FB:FBgn0035001
FB:FBgn0261456
FB:FBgn0267698
MGI:MGI:1344404
MGI:MGI:1346882
MGI:MGI:1349394
MGI:MGI:1355329
MGI:MGI:1858416
MGI:MGI:1917378
MGI:MGI:1920334
PANTHER:PTN000684825
PomBase:SPBC1604.14c
PomBase:SPBC21.06c
RGD:3250
RGD:3251
RGD:621643
RGD:708455
RGD:727905
SGD:S000005242
TAIR:locus:2035989
TAIR:locus:2045658
TAIR:locus:2080394
TAIR:locus:2116417
TAIR:locus:2133559
TAIR:locus:2174969
TAIR:locus:2205523
TAIR:locus:2206885
UniProtKB:A0A0B4KGS4
UniProtKB:C0H4N8
UniProtKB:O75914
UniProtKB:O94804
UniProtKB:O95747
UniProtKB:O95819
UniProtKB:O96013
UniProtKB:Q02750
UniProtKB:Q12851
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q13233
UniProtKB:Q8IVH8
UniProtKB:Q8N4C8
UniProtKB:Q92918
UniProtKB:Q99558
UniProtKB:Q9H2G2
UniProtKB:Q9H2K8
UniProtKB:Q9UEW8
UniProtKB:Q9UKE5
UniProtKB:Q9UL54
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
WB:WBGene00013355
WB:WBGene00017472
dictyBase:DDB_G0276459
dictyBase:DDB_G0286359

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15604234[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15604234[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:15604234[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Chen, Y et al. (2009) Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1. Cell Cycle 8 257-67 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Polci, R et al. (2004) NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res. 64 8800-3 PubMed GONUTS page
  3. ↑ 3.0 3.1 Thiel, C et al. (2011) NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am. J. Hum. Genet. 88 106-14 PubMed GONUTS page
  4. ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:NEK1&oldid=5956385"