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HUMAN:NDOR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NDOR1 (ECO:0000255 with HAMAP-Rule:MF_03178) (synonyms: NR1)
Protein Name(s) NADPH-dependent diflavin oxidoreductase 1 (ECO:0000255 with HAMAP-Rule:MF_03178)

NADPH-dependent FMN and FAD-containing oxidoreductase (ECO:0000255 with HAMAP-Rule:MF_03178) Novel reductase 1

External Links
UniProt Q9UHB4
EMBL AF199509
AY077845
AK074403
AK290026
AL929554
BX255925
BX255925
AL929554
BC015735
BC093782
BC111943
CCDS CCDS48061.1
CCDS48062.1
CCDS48063.1
CCDS7036.1
RefSeq NP_001137498.1
NP_001137499.1
NP_001137500.1
NP_055249.1
UniGene Hs.512564
PDB 4H2D
PDBsum 4H2D
ProteinModelPortal Q9UHB4
SMR Q9UHB4
BioGrid 118038
IntAct Q9UHB4
STRING 9606.ENSP00000360576
PhosphoSite Q9UHB4
BioMuta NDOR1
DMDM 74735011
EPD Q9UHB4
MaxQB Q9UHB4
PaxDb Q9UHB4
PRIDE Q9UHB4
DNASU 27158
Ensembl ENST00000344894
ENST00000371521
ENST00000427047
ENST00000458322
GeneID 27158
KEGG hsa:27158
UCSC uc004clw.4
CTD 27158
GeneCards NDOR1
HGNC HGNC:29838
HPA HPA024504
MIM 606073
neXtProt NX_Q9UHB4
PharmGKB PA134885020
eggNOG KOG1159
COG0369
GeneTree ENSGT00830000128343
HOGENOM HOG000173033
HOVERGEN HBG104950
InParanoid Q9UHB4
OMA AIPPDYL
OrthoDB EOG7QG44B
PhylomeDB Q9UHB4
TreeFam TF105716
BRENDA 1.5.1.30
Reactome R-HSA-2564830
ChiTaRS NDOR1
GeneWiki NDOR1
GenomeRNAi 27158
NextBio 49931
PRO PR:Q9UHB4
Proteomes UP000005640
Bgee Q9UHB4
CleanEx HS_NDOR1
Genevisible Q9UHB4
GO GO:0005737
GO:0005829
GO:0045111
GO:0005634
GO:0048471
GO:0050660
GO:0010181
GO:0005506
GO:0050661
GO:0003958
GO:0016491
GO:0008219
GO:0036245
GO:0016226
GO:0055114
GO:0044281
Gene3D 1.20.990.10
3.40.50.360
HAMAP MF_03178
InterPro IPR003097
IPR017927
IPR001094
IPR008254
IPR001709
IPR029039
IPR023173
IPR028879
IPR001433
IPR017938
Pfam PF00667
PF00258
PF00175
PRINTS PR00369
PR00371
SUPFAM SSF52218
SSF63380
PROSITE PS51384
PS50902

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009055

electron carrier activity

other:GO_REF:0000100

ECO:0000247

PMID:2334437[1]


F

The transfer annotation HHpred hits had an E-value of 3.8E-29, a similarity of 100%, and a query coverage of 95.54% which serves as the evidence.

complete
CACAO 12044

involved_in

GO:0055114

oxidation-reduction process

PMID:15900210[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:12631275[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:15900210[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0036245

cellular response to menadione

PMID:16140270[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:15900210[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:12631275[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

PMID:16140270[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16140270[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10625700[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97744
PANTHER:PTN000453956
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453956
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P35228
UniProtKB:Q9SB48
UniProtKB:Q9UHB4

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453911
UniProtKB:Q9UHB4

C

Seeded From UniProt

complete

enables

GO:0003958

NADPH-hemoprotein reductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453763
PomBase:SPBC29A10.01
RGD:68335
SGD:S000001084
TAIR:locus:2128951
UniProtKB:A0A1D8PLR7
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:P16435
UniProtKB:Q9UBK8

F

Seeded From UniProt

complete

part_of

GO:0045111

intermediate filament cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003958

NADPH-hemoprotein reductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028879

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR008254

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR017927
InterPro:IPR023173

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR017927
InterPro:IPR023173

P

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

C

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

F

Seeded From UniProt

complete

involved_in

GO:0016226

iron-sulfur cluster assembly

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

P

Seeded From UniProt

complete

enables

GO:0016651

oxidoreductase activity, acting on NAD(P)H

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000112755

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Helms, LR et al. (1990) Identification, sequence determination, and expression of the flavodoxin gene from Desulfovibrio salexigens. Biochem. Biophys. Res. Commun. 168 809-17 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Finn, RD et al. (2005) Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. Pharmacogenet. Genomics 15 381-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 Finn, RD et al. (2003) Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. Eur. J. Biochem. 270 1164-75 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Paine, MJ et al. (2000) Cloning and characterization of a novel human dual flavin reductase. J. Biol. Chem. 275 1471-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Kwaśnicka-Crawford, DA & Vincent, SR (2005) Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. Biochem. Biophys. Res. Commun. 336 565-71 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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