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HUMAN:NDEL1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | NDEL1 (synonyms: EOPA, MITAP1, NUDEL) | |
Protein Name(s) | Nuclear distribution protein nudE-like 1
Protein Nudel Mitosin-associated protein 1 | |
External Links | ||
UniProt | Q9GZM8 | |
EMBL | AY004871 AF182078 AF217798 AK056014 DA256375 AL832648 AC026130 CH471108 CH471108 BC026101 | |
CCDS | CCDS11143.1 CCDS32564.1 | |
RefSeq | NP_001020750.1 NP_110435.1 XP_005256863.1 XP_006721644.1 | |
UniGene | Hs.372123 Hs.740680 | |
PDB | 2V66 | |
PDBsum | 2V66 | |
ProteinModelPortal | Q9GZM8 | |
SMR | Q9GZM8 | |
BioGrid | 123527 | |
DIP | DIP-29554N | |
IntAct | Q9GZM8 | |
MINT | MINT-157818 | |
STRING | 9606.ENSP00000333982 | |
PhosphoSite | Q9GZM8 | |
DMDM | 74725006 | |
MaxQB | Q9GZM8 | |
PaxDb | Q9GZM8 | |
PRIDE | Q9GZM8 | |
DNASU | 81565 | |
Ensembl | ENST00000334527 ENST00000402554 | |
GeneID | 81565 | |
KEGG | hsa:81565 | |
UCSC | uc002glj.4 | |
CTD | 81565 | |
GeneCards | GC17P008279 | |
H-InvDB | HIX0135343 | |
HGNC | HGNC:17620 | |
HPA | HPA017916 | |
MIM | 607538 | |
neXtProt | NX_Q9GZM8 | |
PharmGKB | PA134887314 | |
eggNOG | NOG240815 | |
GeneTree | ENSGT00390000000111 | |
HOGENOM | HOG000280681 | |
HOVERGEN | HBG082010 | |
InParanoid | Q9GZM8 | |
KO | K16739 | |
OMA | HTTYFDK | |
OrthoDB | EOG74R1R5 | |
PhylomeDB | Q9GZM8 | |
TreeFam | TF325693 | |
Reactome | REACT_150425 REACT_150471 REACT_682 | |
ChiTaRS | NDEL1 | |
EvolutionaryTrace | Q9GZM8 | |
GeneWiki | NDEL1 | |
GenomeRNAi | 81565 | |
NextBio | 35537434 | |
PRO | PR:Q9GZM8 | |
Proteomes | UP000005640 | |
Bgee | Q9GZM8 | |
CleanEx | HS_NDEL1 | |
ExpressionAtlas | Q9GZM8 | |
Genevestigator | Q9GZM8 | |
GO | GO:0043203 GO:0031252 GO:0005813 GO:0000777 GO:0005737 GO:0005829 GO:0005871 GO:0000776 GO:0005874 GO:0060053 GO:0005635 GO:0005730 GO:0005819 GO:0070012 GO:0032864 GO:0021955 GO:0051642 GO:0021799 GO:0007059 GO:0001833 GO:0000278 GO:0007100 GO:0060052 GO:0001764 GO:1990138 GO:0051081 GO:0045773 GO:0048680 GO:0008090 GO:0047496 | |
InterPro | IPR006964 | |
Pfam | PF04880 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000315 |
P |
Fig. 3 |
complete | |||||
GO:0033157 |
regulation of intracellular protein transport |
ECO:0000315 |
P |
Fig. 5 (especially 5C) |
complete | |||||
involved_in |
GO:1900029 |
positive regulation of ruffle assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032418 |
lysosome localization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033157 |
regulation of intracellular protein transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051642 |
centrosome localization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036059 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051303 |
establishment of chromosome localization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000100519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0047496 |
vesicle transport along microtubule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914453 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016477 |
cell migration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932915 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932915 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008017 |
microtubule binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914453 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007100 |
mitotic centrosome separation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932915 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000100519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007020 |
microtubule nucleation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914453 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005871 |
kinesin complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000100519 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914453 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000776 |
kinetochore |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036059 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000132 |
establishment of mitotic spindle orientation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000100519 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0070012 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008090 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0090724 |
central region of growth cone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0070012 |
oligopeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051081 |
nuclear envelope disassembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048680 |
positive regulation of axon regeneration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045773 |
positive regulation of axon extension |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0044297 |
cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005871 |
kinesin complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q78PB6 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:1990138 |
neuron projection extension |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900029 |
positive regulation of ruffle assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0060053 |
neurofilament cytoskeleton |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060052 |
neurofilament cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051642 |
centrosome localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0048487 |
beta-tubulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0047496 |
vesicle transport along microtubule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043203 |
axon hillock |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0043014 |
alpha-tubulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032418 |
lysosome localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031252 |
cell leading edge |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021955 |
central nervous system neuron axonogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021799 |
cerebral cortex radially oriented cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016477 |
cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008090 |
retrograde axonal transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008017 |
microtubule binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007100 |
mitotic centrosome separation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005875 |
microtubule associated complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001833 |
inner cell mass cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001764 |
neuron migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000226 |
microtubule cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERR1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007100 |
mitotic centrosome separation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060052 |
neurofilament cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000574 |
regulation of microtubule motor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5666169 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000777 |
condensed chromosome kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005819 |
spindle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Chansard, M et al. (2011) The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity. PLoS ONE 6 e14583 PubMed GONUTS page
- ↑ 2.0 2.1 Vergnolle, MA & Taylor, SS (2007) Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. Curr. Biol. 17 1173-9 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Soares, DC et al. (2012) The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution. J. Biol. Chem. 287 32381-93 PubMed GONUTS page
- ↑ Derewenda, U et al. (2007) The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure 15 1467-81 PubMed GONUTS page
- ↑ Efimov, VP & Morris, NR (2000) The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J. Cell Biol. 150 681-8 PubMed GONUTS page
a
c
- Catarrhini
- GO:0044297 ! cell body
- GO:0030154 ! cell differentiation
- GO:0031252 ! cell leading edge
- GO:0016477 ! cell migration
- GO:0021955 ! central nervous system neuron axonogenesis
- GO:0090724 ! central region of growth cone
- GO:0005813 ! centrosome
- GO:0051642 ! centrosome localization
- GO:0021799 ! cerebral cortex radially oriented cell migration
- Chordata
- GO:0005694 ! chromosome
- GO:0000775 ! chromosome, centromeric region
- GO:0007059 ! chromosome segregation
- GO:0000777 ! condensed chromosome kinetochore
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
i
m
- Mammalia
- Metazoa
- GO:0005874 ! microtubule
- GO:0008017 ! microtubule binding
- GO:0005875 ! microtubule associated complex
- GO:0005815 ! microtubule organizing center
- GO:0007020 ! microtubule nucleation
- GO:0000226 ! microtubule cytoskeleton organization
- GO:0007100 ! mitotic centrosome separation
- GO:0007275 ! multicellular organism development
n
- GO:0007399 ! nervous system development
- GO:0060053 ! neurofilament cytoskeleton
- GO:0060052 ! neurofilament cytoskeleton organization
- GO:0001764 ! neuron migration
- GO:0031175 ! neuron projection development
- GO:1990138 ! neuron projection extension
- GO:0005635 ! nuclear envelope
- GO:0051081 ! nuclear membrane disassembly
o
p
r