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HUMAN:NDEL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NDEL1 (synonyms: EOPA, MITAP1, NUDEL)
Protein Name(s) Nuclear distribution protein nudE-like 1

Protein Nudel Mitosin-associated protein 1

External Links
UniProt Q9GZM8
EMBL AY004871
AF182078
AF217798
AK056014
DA256375
AL832648
AC026130
CH471108
CH471108
BC026101
CCDS CCDS11143.1
CCDS32564.1
RefSeq NP_001020750.1
NP_110435.1
XP_005256863.1
XP_006721644.1
UniGene Hs.372123
Hs.740680
PDB 2V66
PDBsum 2V66
ProteinModelPortal Q9GZM8
SMR Q9GZM8
BioGrid 123527
DIP DIP-29554N
IntAct Q9GZM8
MINT MINT-157818
STRING 9606.ENSP00000333982
PhosphoSite Q9GZM8
DMDM 74725006
MaxQB Q9GZM8
PaxDb Q9GZM8
PRIDE Q9GZM8
DNASU 81565
Ensembl ENST00000334527
ENST00000402554
GeneID 81565
KEGG hsa:81565
UCSC uc002glj.4
CTD 81565
GeneCards GC17P008279
H-InvDB HIX0135343
HGNC HGNC:17620
HPA HPA017916
MIM 607538
neXtProt NX_Q9GZM8
PharmGKB PA134887314
eggNOG NOG240815
GeneTree ENSGT00390000000111
HOGENOM HOG000280681
HOVERGEN HBG082010
InParanoid Q9GZM8
KO K16739
OMA HTTYFDK
OrthoDB EOG74R1R5
PhylomeDB Q9GZM8
TreeFam TF325693
Reactome REACT_150425
REACT_150471
REACT_682
ChiTaRS NDEL1
EvolutionaryTrace Q9GZM8
GeneWiki NDEL1
GenomeRNAi 81565
NextBio 35537434
PRO PR:Q9GZM8
Proteomes UP000005640
Bgee Q9GZM8
CleanEx HS_NDEL1
ExpressionAtlas Q9GZM8
Genevestigator Q9GZM8
GO GO:0043203
GO:0031252
GO:0005813
GO:0000777
GO:0005737
GO:0005829
GO:0005871
GO:0000776
GO:0005874
GO:0060053
GO:0005635
GO:0005730
GO:0005819
GO:0070012
GO:0032864
GO:0021955
GO:0051642
GO:0021799
GO:0007059
GO:0001833
GO:0000278
GO:0007100
GO:0060052
GO:0001764
GO:1990138
GO:0051081
GO:0045773
GO:0048680
GO:0008090
GO:0047496
InterPro IPR006964
Pfam PF04880

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043547

positive regulation of GTPase activity

PMID:21283621[1]

ECO:0000315

P

Fig. 3

complete
CACAO 2460

GO:0033157

regulation of intracellular protein transport

PMID:21283621[1]

ECO:0000315

P

Fig. 5 (especially 5C)

complete
CACAO 2461

involved_in

GO:1900029

positive regulation of ruffle assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ERR1

P

Seeded From UniProt

complete

involved_in

GO:0032418

lysosome localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ERR1

P

Seeded From UniProt

complete

involved_in

GO:0033157

regulation of intracellular protein transport

PMID:21283621[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:21283621[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

PMID:17600710[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:17600710[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051642

centrosome localization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036059
MGI:MGI:1932915
PANTHER:PTN000100519

P

Seeded From UniProt

complete

involved_in

GO:0051303

establishment of chromosome localization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000100519
UniProtKB:Q9NXR1

P

Seeded From UniProt

complete

involved_in

GO:0047496

vesicle transport along microtubule

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914453
MGI:MGI:1932915
PANTHER:PTN000100519

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1932915
PANTHER:PTN000100519

P

Seeded From UniProt

complete

involved_in

GO:0010975

regulation of neuron projection development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1932915
PANTHER:PTN000100554
RGD:621235

P

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914453
MGI:MGI:1932915
PANTHER:PTN000100519

F

Seeded From UniProt

complete

involved_in

GO:0007100

mitotic centrosome separation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1932915
PANTHER:PTN000100519

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000100519
UniProtKB:Q9GZM8

P

Seeded From UniProt

complete

involved_in

GO:0007020

microtubule nucleation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914453
PANTHER:PTN000100519

P

Seeded From UniProt

complete

part_of

GO:0005871

kinesin complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000100519
RGD:621235

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914453
MGI:MGI:1932915
PANTHER:PTN000100519
RGD:621235
UniProtKB:Q9NXR1

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036059
PANTHER:PTN000100519
UniProtKB:Q9GZM8
UniProtKB:Q9NXR1

C

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000100519
UniProtKB:Q9NXR1

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9GZM8

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22843697[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9GZM8

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17997972[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9GZM8

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:10931877[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9GZM8

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0070012

P

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008090

C

Seeded From UniProt

complete

part_of

GO:0090724

central region of growth cone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

enables

GO:0070012

oligopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

F

Seeded From UniProt

complete

involved_in

GO:0051081

nuclear envelope disassembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

P

Seeded From UniProt

complete

involved_in

GO:0048680

positive regulation of axon regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

P

Seeded From UniProt

complete

involved_in

GO:0045773

positive regulation of axon extension

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

F

Seeded From UniProt

complete

part_of

GO:0044297

cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

involved_in

GO:0010975

regulation of neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

P

Seeded From UniProt

complete

part_of

GO:0005871

kinesin complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q78PB6
ensembl:ENSRNOP00000005574

C

Seeded From UniProt

complete

involved_in

GO:1990138

neuron projection extension

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:1900029

positive regulation of ruffle assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

part_of

GO:0060053

neurofilament cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

involved_in

GO:0060052

neurofilament cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0051642

centrosome localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

enables

GO:0048487

beta-tubulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

F

Seeded From UniProt

complete

involved_in

GO:0047496

vesicle transport along microtubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

part_of

GO:0043203

axon hillock

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

enables

GO:0043014

alpha-tubulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

F

Seeded From UniProt

complete

involved_in

GO:0032418

lysosome localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

part_of

GO:0031252

cell leading edge

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

involved_in

GO:0021955

central nervous system neuron axonogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0021799

cerebral cortex radially oriented cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0010975

regulation of neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0008286

insulin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0008090

retrograde axonal transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

F

Seeded From UniProt

complete

involved_in

GO:0007100

mitotic centrosome separation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

part_of

GO:0005875

microtubule associated complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

C

Seeded From UniProt

complete

involved_in

GO:0001833

inner cell mass cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERR1
ensembl:ENSMUSP00000018880

P

Seeded From UniProt

complete

involved_in

GO:0007100

mitotic centrosome separation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033493

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033493

P

Seeded From UniProt

complete

involved_in

GO:0060052

neurofilament cytoskeleton organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033493

P

Seeded From UniProt

complete

involved_in

GO:2000574

regulation of microtubule motor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033493
InterPro:IPR033494

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Chansard, M et al. (2011) The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity. PLoS ONE 6 e14583 PubMed GONUTS page
  2. 2.0 2.1 Vergnolle, MA & Taylor, SS (2007) Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. Curr. Biol. 17 1173-9 PubMed GONUTS page
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