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HUMAN:NAL10
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NLRP10 (synonyms: NALP10, NOD8, PYNOD) | |
| Protein Name(s) | NACHT, LRR and PYD domains-containing protein 10
Nucleotide-binding oligomerization domain protein 8 | |
| External Links | ||
| UniProt | Q86W26 | |
| EMBL | AY154465 AY489192 BK001110 BC104957 | |
| CCDS | CCDS7784.1 | |
| RefSeq | NP_789791.1 | |
| UniGene | Hs.449636 | |
| PDB | 2M5V | |
| PDBsum | 2M5V | |
| ProteinModelPortal | Q86W26 | |
| SMR | Q86W26 | |
| BioGrid | 130709 | |
| STRING | 9606.ENSP00000327763 | |
| PhosphoSite | Q86W26 | |
| DMDM | 46396380 | |
| PaxDb | Q86W26 | |
| PRIDE | Q86W26 | |
| Ensembl | ENST00000328600 ENST00000612291 | |
| GeneID | 338322 | |
| KEGG | hsa:338322 | |
| UCSC | uc001mfv.1 | |
| CTD | 338322 | |
| GeneCards | GC11M007980 | |
| HGNC | HGNC:21464 | |
| HPA | HPA039498 HPA040101 | |
| MIM | 609662 | |
| neXtProt | NX_Q86W26 | |
| PharmGKB | PA162397832 | |
| eggNOG | NOG145856 | |
| GeneTree | ENSGT00770000120466 | |
| HOGENOM | HOG000113728 | |
| HOVERGEN | HBG052572 | |
| InParanoid | Q86W26 | |
| OMA | DIFMAYV | |
| OrthoDB | EOG7P5T07 | |
| PhylomeDB | Q86W26 | |
| GeneWiki | NLRP10 | |
| GenomeRNAi | 338322 | |
| NextBio | 96929 | |
| PRO | PR:Q86W26 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | Q86W26 | |
| CleanEx | HS_NLRP10 | |
| ExpressionAtlas | Q86W26 | |
| Genevestigator | Q86W26 | |
| GO | GO:0005737 GO:0019897 GO:0005524 GO:0050832 GO:0050829 GO:0036336 GO:0035397 GO:0045087 GO:2000778 GO:2000484 GO:0002827 GO:2000318 | |
| Gene3D | 1.10.533.10 3.40.50.300 | |
| InterPro | IPR004020 IPR011029 IPR007111 IPR027417 | |
| Pfam | PF02758 | |
| SUPFAM | SSF47986 SSF52540 | |
| PROSITE | PS50824 PS50837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900426 |
positive regulation of defense response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050717 |
positive regulation of interleukin-1 alpha secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000318 |
positive regulation of T-helper 17 type immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002827 |
positive regulation of T-helper 1 type immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000318 |
positive regulation of T-helper 17 type immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8CCN1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8CCN1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8CCN1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002827 |
positive regulation of T-helper 1 type immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8CCN1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Su, MY et al. (2013) Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue. PLoS ONE 8 e67843 PubMed GONUTS page
- ↑ 2.0 2.1 Lee, SJ & Choi, BK (2017) Involvement of NLRP10 in IL-1α induction of oral epithelial cells by periodontal pathogens. Innate Immun 23 569-577 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Lautz, K et al. (2012) NLRP10 enhances Shigella-induced pro-inflammatory responses. Cell. Microbiol. 14 1568-83 PubMed GONUTS page
a
e
i
p
- GO:0005886 ! plasma membrane
- GO:0002827 ! positive regulation of T-helper 1 type immune response
- GO:2000318 ! positive regulation of T-helper 17 type immune response
- GO:2000484 ! positive regulation of interleukin-8 secretion
- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:0050717 ! positive regulation of interleukin-1 alpha secretion
- GO:1900426 ! positive regulation of defense response to bacterium
- GO:0050729 ! positive regulation of inflammatory response
- Primates
